FS
F. Schmidt
kineticsself-immolationAuristatindisassemblyLigand induced-fitphotochemistryShiga toxinantibody-drug conjugatesbiocatalysisbiochemistry
On Valency
published · living versionsW_gur2am6v·v1 · currentpublished
Studies of Cosmic Ray Composition and Air Shower Structure with the Pierre Auger Observatory
with The Pierre Auger Collaboration, J. Abraham, P. Abreu, M. Aglietta +468
1 version
Preprints & journals
36 papers in the corpus · 1999–2023A synthetic delivery vector for mucosal vaccination.37713762 · Billet, Anne, Hadjerci, Justine, Tran, Thi et al.2023 · 7 citationsBiomaterials. 2023;302:122298
A double-triggered self-immolative spacer for increased selectivity of molecular release.34897358 · Huvelle, Steve, Le Saux, Thomas, Jullien, Ludovic et al.2022 · 2 citationsOrganic & biomolecular chemistry. 2021;20(1):240-246
Absolute Quantification of Drug Vector Delivery to the Cytosol.33904231 · Lucchino, Marco, Billet, Anne, Bai, Siau-Kun et al.2021 · 23 citationsAngewandte Chemie (International ed. in English). 2021;60(27):14824-14830
Datasets and analyses of molecular dynamics simulations of covalent binary and ternary complexes of MHC class I-related molecule/T-cell receptor (MR1/TCR) agonists to understand complex formation and conditions of fluorescent labelling.33506079 · Steinmetz, Anke, Yvorra, Thomas, Retailleau, Pascal et al.2021 · 8 citationsData in brief. 2021;34:106704
Synthesis, biological evaluation and molecular modelling of new potent clickable analogues of 5-OP-RU for their use as chemical probes for the study of MAIT cell biology.33341648 · Yvorra, Thomas, Steinmetz, Anke, Retailleau, Pascal et al.2021 · 12 citationsEuropean journal of medicinal chemistry. 2021;211:113066
Microbial metabolites control the thymic development of mucosal-associated invariant T cells.31467190 · Legoux, François, Bellet, Déborah, Daviaud, Celine et al.2020 · 320 citationsScience (New York, N.Y.). 2019;366(6464):494-499
2nd PSL Chemical Biology Symposium (2019): At the Crossroads of Chemistry and Biology.30803119 · Lucchino, Marco, Billet, Anne, Versini, Antoine et al.2020 · 2 citationsChembiochem : a European journal of chemical biology. 2019;20(7):968-973
A chemically encoded timer for dual molecular delivery at tailored ranges and concentrations.29872786 · Serra, Silvia, Alouane, Ahmed, Le Saux, Thomas et al.2018 · 5 citationsChemical communications (Cambridge, England). 2018;54(49):6396-6399
Syntheses and kinetic studies of cyclisation-based self-immolative spacers.28358149 · Huvelle, Steve, Alouane, Ahmed, Le Saux, Thomas et al.2018 · 26 citationsOrganic & biomolecular chemistry. 2017;15(16):3435-3443
Effective antitumor therapy based on a novel antibody-drug conjugate targeting the Tn carbohydrate antigen.27622021 · Sedlik, Christine, Heitzmann, Adèle, Viel, Sophie et al.2016 · 26 citationsOncoimmunology. 2016;5(7):e1171434
Targeted Shiga toxin-drug conjugates prepared via Cu-free click chemistry.26507432 · Kostova, Vesela, Dransart, Estelle, Azoulay, Michel et al.2016 · 22 citationsBioorganic & medicinal chemistry. 2015;23(22):7150-7
Self-immolative spacers: kinetic aspects, structure-property relationships, and applications.26053475 · Alouane, Ahmed, Labruère, Raphaël, Le Saux, Thomas et al.2016 · 381 citationsAngewandte Chemie (International ed. in English). 2015;54(26):7492-509
In Vitro and In Vivo Analysis of the Gram-Negative Bacteria-Derived Riboflavin Precursor Derivatives Activating Mouse MAIT Cells.25870247 · Soudais, Claire, Samassa, Fatoumata, Sarkis, Manal et al.2015 · 119 citationsJournal of immunology (Baltimore, Md. : 1950). 2015;194(10):4641-9
A new delivery system for auristatin in STxB-drug conjugate therapy.25847766 · Batisse, Cornélie, Dransart, Estelle, Ait Sarkouh, Rafik et al.2016 · 41 citationsEuropean journal of medicinal chemistry. 2015;95:483-91
Interfacing chemical biology and drug discovery: report from the 50th International Conference on Medicinal Chemistry of the SCT (French Medicinal Chemistry Society), July 2-4, 2014, Rouen, France.25476010 · Sapi, Janos, Schmidt, Frédéric, Van Hijfte, Luc et al.2015 · 1 citationACS chemical biology. 2014;9(12):2702-7
Chemical biology: contribution to molecular therapeutic innovation--a new role for chemistry? Report from the thematic symposium organized by the SCT (French Medicinal Chemistry Society), November 26th, 2013.24742389 · Schmidt, Frédéric, George, Pascal, Sapi, Janos2015 · 1 citationACS chemical biology. 2014;9(4):849-52
Disassembly kinetics of quinone-methide-based self-immolative spacers that contain aromatic nitrogen heterocycles.24652669 · Alouane, Ahmed, Labruère, Raphaël, Silvestre, Katherine J et al.2015 · 15 citationsChemistry, an Asian journal. 2014;9(5):1334-40
Light activation for the versatile and accurate kinetic analysis of disassembly of self-immolative spacers.23861286 · Alouane, Ahmed, Labruère, Raphaël, Le Saux, Thomas et al.2014 · 34 citationsChemistry (Weinheim an der Bergstrasse, Germany). 2013;19(35):11717-24
"Self-immolative" spacer for uncaging with fluorescence reporting.22930567 · Labruère, Raphaël, Alouane, Ahmed, Le Saux, Thomas et al.2013 · 45 citationsAngewandte Chemie (International ed. in English). 2012;51(37):9344-7
Palladium-catalyzed synthesis of 2,3-disubstituted 5-azaindoles via heteroannulation reaction and of 2-substituted 5-azaindoles through domino sila-Sonogashira/5-endo cyclization.22587741 · Livecchi, Marion, Calvet, Géraldine, Schmidt, Frédéric2012 · 34 citationsThe Journal of organic chemistry. 2012;77(11):5006-16
Synthesis of polysubstituted 5-azaindoles via palladium-catalyzed heteroannulation of diarylalkynes.21500844 · Calvet, Géraldine, Livecchi, Marion, Schmidt, Frédéric2011 · 19 citationsThe Journal of organic chemistry. 2011;76(11):4734-40
Optimizing the formation of biocompatible gold nanorods for cancer research: functionalization, stabilization and purification.21334635 · Bogliotti, Nicolas, Oberleitner, Birgit, Di-Cicco, Aurélie et al.2011 · 33 citationsJournal of colloid and interface science. 2011;357(1):75-81
Antitumor activity of pyridocarbazole and benzopyridoindole derivatives that inhibit protein kinase CK2.21118972 · Prudent, Renaud, Moucadel, Virginie, Nguyen, Chi-Hung et al.2011 · 82 citationsCancer research. 2010;70(23):9865-74
New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights.20400536 · López-Ramos, Miriam, Prudent, Renaud, Moucadel, Virginie et al.2010 · 64 citationsFASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2010;24(9):3171-85
Synthesis and properties of a mitochondrial peripheral benzodiazepine receptor conjugate.18846592 · El Alaoui, Abdessamad, Schmidt, Frédéric, Sarr, Marianne et al.2009 · 23 citationsChemMedChem. 2008;3(11):1687-95
Salicylaldehyde derivatives as new protein kinase CK2 inhibitors.18674590 · Prudent, Renaud, López-Ramos, Miriam, Moucadel, Virginie et al.2009 · 12 citationsBiochimica et biophysica acta. 2008;1780(12):1412-20
Expanding the chemical diversity of CK2 inhibitors.18563535 · Prudent, Renaud, Moucadel, Virginie, López-Ramos, Miriam et al.2008 · 35 citationsMolecular and cellular biochemistry. 2008;316(1-2):71-85
New triarylamine-based far-red DNA stainers with high two-photon absorption properties.18776300 · Bordeau, G, Faurel, E, Allain, C et al.2010 · 2 citationsNucleic acids symposium series (2004). 2008(52):155-6
Shiga toxin-mediated retrograde delivery of a topoisomerase I inhibitor prodrug.17645270 · El Alaoui, Abdessamad, Schmidt, Frédéric, Amessou, Mohamed et al.2007 · 88 citationsAngewandte Chemie (International ed. in English). 2007;46(34):6469-72
Protecting groups for glucuronic acid: application to the synthesis of new paclitaxel (taxol) derivatives.17168579 · El Alaoui, Abdessamad, Schmidt, Frédéric, Monneret, Claude et al.2007 · 46 citationsThe Journal of organic chemistry. 2006;71(26):9628-36
New Taxol (paclitaxel) prodrugs designed for ADEPT and PMT strategies in cancer chemotherapy.16554162 · Alaoui, Abdessamad El, Saha, Nabendu, Schmidt, Frédéric et al.2006 · 54 citationsBioorganic & medicinal chemistry. 2006;14(14):5012-9
First enzymatically activated Taxotere prodrugs designed for ADEPT and PMT.14980610 · Bouvier, Emmanuel, Thirot, Sylvie, Schmidt, Frédéric et al.2004 · 28 citationsBioorganic & medicinal chemistry. 2004;12(5):969-77
A new paclitaxel prodrug for use in ADEPT strategy.14584798 · Bouvier, Emmanuel, Thirot, Sylvie, Schmidt, Frédéric et al.2004 · 42 citationsOrganic & biomolecular chemistry. 2003;1(19):3343-52
Prodrug Mono Therapy: synthesis and biological evaluation of an etoposide glucuronide-prodrug.12713838 · Schmidt, Frédéric, Monneret, Claude2004 · 26 citationsBioorganic & medicinal chemistry. 2003;11(10):2277-83
Cancer chemotherapy: a SN-38 (7-ethyl-10-hydroxycamptothecin) glucuronide prodrug for treatment by a PMT (Prodrug MonoTherapy) strategy.12617927 · Angenault, Stéphane, Thirot, Sylvie, Schmidt, Frédéric et al.2003 · 18 citationsBioorganic & medicinal chemistry letters. 2003;13(5):947-50
Application of the ADEPT strategy to the MDR resistance in cancer chemotherapy.10405636 · Desbene, S, Van, H D, Michel, S et al.1999 · 13 citationsAnti-cancer drug design. 1999;14(2):93-106
Career total: 87 works. 36 are in this corpus.
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