EC
Edwin Chen
Mutationcs.AIDisease Models, AnimalHomozygoteactivationCalreticulinCell Cycle CheckpointsCell Transformation, NeoplasticComputational Biologycryo-EM
On Valency
published · living versionsW_63ueycek·v1 · currentpublished
Discovering Language Model Behaviors with Model-Written Evaluations
with Ethan Perez, Sam Ringer, Kamilė Lukošiūtė, Karina Nguyen +58
1 version
Preprints & journals
34 papers in the corpus · 2000–2026The Hierarchy of Agentic Capabilities: Evaluating Frontier Models on Realistic RL Environments2601.09032v1 · Logan Ritchie, Sushant Mehta, Nick Heiner et al.2026 · 0 citationsarXiv
Author Correction: Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9.39443719 · Schneider, Rebekka K, Schenone, Monica, Ferreira, Monica Ventura et al.2024 · 1 citationNature medicine. 2024;30(11):3382
Discovering Language Model Behaviors with Model-Written Evaluations2212.09251v1 · Ethan Perez, Sam Ringer, Kamil\.e Lukosi\=ut\.e et al.2022 · 224 citationsarXivon Valency
Zinc-dependent multimerization of mutant calreticulin is required for MPL binding and MPN pathogenesis.33821991 · Rivera, Jeanne F, Baral, April J, Nadat, Fatima et al.2021 · 14 citationsBlood advances. 2021;5(7):1922-1932
Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML.33351783 · Tothova, Zuzana, Valton, Anne-Laure, Gorelov, Rebecca A et al.2021 · 94 citationsJCI insight. 2021;6(3)
Mechanism of completion of peptidyltransferase centre assembly in eukaryotes.31115337 · Kargas, Vasileios, Castro-Hartmann, Pablo, Escudero-Urquijo, Norberto et al.2020 · 71 citationseLife. 2019;8
Defining the requirements for the pathogenic interaction between mutant calreticulin and MPL in MPN.29288169 · Elf, Shannon, Abdelfattah, Nouran S, Baral, April J et al.2019 · 92 citationsBlood. 2018;131(7):782-786
JAK2V617F mediates resistance to DNA damage-induced apoptosis by modulating FOXO3A localization and Bcl-xL deamidation.26234675 · Ahn, J S, Li, J, Chen, E et al.2017 · 30 citationsOncogene. 2016;35(17):2235-46
Mutant Calreticulin Requires Both Its Mutant C-terminus and the Thrombopoietin Receptor for Oncogenic Transformation.26951227 · Elf, Shannon, Abdelfattah, Nouran S, Chen, Edwin et al.2016 · 299 citationsCancer discovery. 2016;6(4):368-81
STAT1 activation in association with JAK2 exon 12 mutations.26635038 · Godfrey, Anna L, Chen, Edwin, Massie, Charles E et al.2016 · 17 citationsHaematologica. 2016;101(1):e15-9
RECQL5 Suppresses Oncogenic JAK2-Induced Replication Stress and Genomic Instability.26686625 · Chen, Edwin, Ahn, Jong Sook, Sykes, David B et al.2016 · 31 citationsCell reports. 2015;13(11):2345-2352
Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9.26878232 · Schneider, Rebekka K, Schenone, Monica, Ferreira, Monica Ventura et al.2016 · 256 citationsNature medicine. 2016;22(3):288-97
Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms.25849990 · Tapper, William, Jones, Amy V, Kralovics, Robert et al.2016 · 169 citationsNature communications. 2015;6:6691
How does JAK2V617F contribute to the pathogenesis of myeloproliferative neoplasms?25696866 · Chen, Edwin, Mullally, Ann2015 · 46 citationsHematology. American Society of Hematology. Education Program. 2014;2014(1):268-76
Postnatal Notch1 activation induces T‑cell malignancy in conditional and inducible mouse models.25175815 · Liu, Ju, Dong, Fengyun, Fung, Iris et al.2015 · 0 citationsInternational journal of oncology. 2014;45(5):1997-2004
JAK2V617F promotes replication fork stalling with disease-restricted impairment of the intra-S checkpoint response.25288776 · Chen, Edwin, Ahn, Jong Sook, Massie, Charlie E et al.2015 · 51 citationsProceedings of the National Academy of Sciences of the United States of America. 2014;111(42):15190-5
Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice promote disease progression in myeloproliferative neoplasms.25281607 · Chen, Edwin, Schneider, Rebekka K, Breyfogle, Lawrence J et al.2015 · 105 citationsBlood. 2015;125(2):327-35
Ectopic TLX1 expression accelerates malignancies in mice deficient in DNA-PK.24586935 · Krutikov, Konstantin, Zheng, Yanzhen, Chesney, Alden et al.2015 · 2 citationsPloS one. 2014;9(2):e89649
JAK2V617F homozygosity drives a phenotypic switch in myeloproliferative neoplasms, but is insufficient to sustain disease.24692758 · Li, Juan, Kent, David G, Godfrey, Anna L et al.2014 · 96 citationsBlood. 2014;123(20):3139-51
Clonal analyses reveal associations of JAK2V617F homozygosity with hematologic features, age and gender in polycythemia vera and essential thrombocythemia.23633544 · Godfrey, Anna L, Chen, Edwin, Pagano, Francesca et al.2013 · 41 citationsHaematologica. 2013;98(5):718-21
JAK2V617F homozygosity arises commonly and recurrently in PV and ET, but PV is characterized by expansion of a dominant homozygous subclone.22898600 · Godfrey, Anna L, Chen, Edwin, Pagano, Francesca et al.2013 · 108 citationsBlood. 2012;120(13):2704-7
The transcription factor encyclopedia.22458515 · Yusuf, Dimas, Butland, Stefanie L, Swanson, Magdalena I et al.2012 · 160 citationsGenome biology. 2012;13(3):R24
Janus kinase deregulation in leukemia and lymphoma.22520846 · Chen, Edwin, Staudt, Louis M, Green, Anthony R2012 · 126 citationsImmunity. 2012;36(4):529-41
Mouse models of myeloproliferative neoplasms: JAK of all grades.21558064 · Li, Juan, Kent, David G, Chen, Edwin et al.2011 · 97 citationsDisease models & mechanisms. 2011;4(3):311-7
Phosphorylation of HOX11/TLX1 on Threonine-247 during mitosis modulates expression of cyclin B1.20846384 · Chen, Edwin, Huang, Xiaoyong, Zheng, Yanzhen et al.2011 · 4 citationsMolecular cancer. 2010;9:246
Distinct clinical phenotypes associated with JAK2V617F reflect differential STAT1 signaling.21074499 · Chen, Edwin, Beer, Philip A, Godfrey, Anna L et al.2010 · 175 citationsCancer cell. 2010;18(5):524-35
JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia.20489053 · Li, Juan, Spensberger, Dominik, Ahn, Jong Sook et al.2010 · 209 citationsBlood. 2010;116(9):1528-38
Two routes to leukemic transformation after a JAK2 mutation-positive myeloproliferative neoplasm.20008300 · Beer, Philip A, Delhommeau, François, LeCouédic, Jean-Pierre et al.2010 · 309 citationsBlood. 2010;115(14):2891-900
ID1 promotes expansion and survival of primary erythroid cells and is a target of JAK2V617F-STAT5 signaling.19571317 · Wood, Andrew D, Chen, Edwin, Donaldson, Ian J et al.2009 · 49 citationsBlood. 2009;114(9):1820-30
Loss of Ubr1 promotes aneuploidy and accelerates B-cell lymphomagenesis in TLX1/HOX11-transgenic mice.16862188 · Chen, E, Kwon, Y T, Lim, M S et al.2006 · 14 citationsOncogene. 2006;25(42):5752-63
Dysregulated expression of mitotic regulators is associated with B-cell lymphomagenesis in HOX11-transgenic mice.16407851 · Chen, E, Lim, M S, Rosic-Kablar, S et al.2006 · 18 citationsOncogene. 2006;25(18):2575-87
Gene expression profiling in the inductive human hematopoietic microenvironment.15369807 · Zhao, Yongjun, Chen, Edwin, Li, Liheng et al.2004 · 3 citationsBiochemical and biophysical research communications. 2004;323(2):703-11
Characterization of elongation factor-1A (eEF1A-1) and eEF1A-2/S1 protein expression in normal and wasted mice.11294870 · Khalyfa, A, Bourbeau, D, Chen, E et al.2001 · 104 citationsThe Journal of biological chemistry. 2001;276(25):22915-22
Rapid up-regulation of peptide elongation factor EF-1alpha protein levels is an immediate early event during oxidative stress-induced apoptosis.10942586 · Chen, E, Proestou, G, Bourbeau, D et al.2000 · 110 citationsExperimental cell research. 2000;259(1):140-8
Career total: 64 works. 34 are in this corpus.
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