SM
Sergey Melnikov
evolutionary biologyribosomeProtein BiosynthesismistranslationRibosomesaminoacyl-tRNA synthetasesantimicrobial resistanceMuller’s ratchetRibosomal ProteinstRNA
On Valency
published · living versionsW_26xzgw86·v1 · currentpublished
Assemblathon 2: evaluating de novo methods of genome assembly in three vertebrate species
with Keith R. Bradnam, Joseph N. Fass, Anton Alexandrov, Paul Baranay +86
1 version
Preprints & journals
42 papers in the corpus · 2005–2025The evolution lifecycle of ribosome hibernation factors10.1101/2025.11.04.686544v2 · Chan, L. I., Omae, K., Brown, C. R. et al.2025 · 5 citationsbioRxiv
Translon: a single term for translated regions.40890551 · Świrski, Michał I, Tierney, Jack A S, Albà, M Mar et al.2026 · 20 citationsNature methods. 2025;22(10):2002-2006
Evolution of drug-binding residues in eukaryotic ribosomes.40944914 · Chan, Lewis I, Ekemezie, Chinenye L, Brown, Charlotte R et al.2025 · 1 citationCell reports. 2025;44(9):116244
Extensive natural variation in bacterial ribosomal drug-binding sites.40536873 · Ekemezie, Chinenye L, Chan, Lewis I, Brown, Charlotte R et al.2025 · 2 citationsCell reports. 2025;44(7):115878
Structurally heterogeneous ribosomes cooperate in protein synthesis in bacterial cells.40113756 · Helena-Bueno, Karla, Kopetschke, Sophie, Filbeck, Sebastian et al.2025 · 9 citationsNature communications. 2025;16(1):2751
Evolution of drug-binding residues in bacterial ribosomes10.1101/2024.10.31.621234v3 · Ekemezie, C. L., Chan, L. I., Brown, C. R. et al.2024 · 1 citationbioRxiv
Hibernating ribosomes as drug targets?39135874 · Ekemezie, Chinenye L, Melnikov, Sergey V2024 · 15 citationsFrontiers in microbiology. 2024;15:1436579
Rippling life on a dormant planet: hibernation of ribosomes, RNA polymerases, and other essential enzymes.38770025 · Helena-Bueno, Karla, Chan, Lewis I, Melnikov, Sergey V2024 · 22 citationsFrontiers in microbiology. 2024;15:1386179
Engineered mRNA-ribosome fusions for facile biosynthesis of selenoproteins.38442159 · Thaenert, Anna, Sevostyanova, Anastasia, Chung, Christina Z et al.2024 · 5 citationsProceedings of the National Academy of Sciences of the United States of America. 2024;121(11):e2321700121
A new family of bacterial ribosome hibernation factors.38355796 · Helena-Bueno, Karla, Rybak, Mariia Yu, Ekemezie, Chinenye L et al.2024 · 53 citationsNature. 2024;626(8001):1125-1132
tRNA shape is an identity element for an archaeal pyrrolysyl-tRNA synthetase from the human gut.38100361 · Krahn, Natalie, Zhang, Jingji, Melnikov, Sergey V et al.2024 · 13 citationsNucleic acids research. 2024;52(2):513-524
A Conserved Ribosomal Protein Has Entirely Dissimilar Structures in Different Organisms.37987564 · Schierholz, Léon, Brown, Charlotte R, Helena-Bueno, Karla et al.2024 · 7 citationsMolecular biology and evolution. 2024;41(1)
Ribosomal proteins can hold a more accurate record of bacterial thermal adaptation compared to rRNA.37395434 · van den Elzen, Antonia, Helena-Bueno, Karla, Brown, Charlotte R et al.2023 · 8 citationsNucleic acids research. 2023;51(15):8048-8059
A bacterial ribosome hibernation factor with evolutionary connections to eukaryotic protein synthesis10.1101/2022.11.24.517861v2 · Helena-Bueno, K., Ekemezie, C. L., Brown, C. R. et al.2022 · 0 citationsbioRxiv
Ribosomes as molecular thermometers: metal-binding sites in ribosomal proteins are robust indicators of bacterial adaptation to heat and cold10.1101/2022.09.09.507293v1 · van den Elzen, A., Helena-Bueno, K., Brown, C. R. et al.2022 · 0 citationsbioRxiv
Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.35105900 · Nicholson, David, Salamina, Marco, Panek, Johan et al.2022 · 38 citationsNature communications. 2022;13(1):591
Gosha: a database of organisms with defined optimal growth temperatures10.1101/2021.12.21.473645v2 · Helena-Bueno, K., Brown, C. R., Melnikov, S.2021 · 10 citationsbioRxiv
'Lose-to-gain' adaptation to genome decayin the structure of the smallest eukaryotic ribosomes10.1101/2021.09.06.458831v1 · Nicholson, D., Salamina, M., Panek, J. et al.2021 · 1 citationbioRxiv
Bacterial translation machinery for deliberate mistranslation of the genetic code.34413202 · Vargas-Rodriguez, Oscar, Badran, Ahmed H, Hoffman, Kyle S et al.2021 · 18 citationsProceedings of the National Academy of Sciences of the United States of America. 2021;118(35)
Exploiting evolutionary trade-offs for posttreatment management of drug-resistant populations.32661175 · Melnikov, Sergey V, Stevens, David L, Fu, Xian et al.2020 · 35 citationsProceedings of the National Academy of Sciences of the United States of America. 2020;117(30):17924-17931
Exploiting evolutionary trade-offs to combat antibiotic resistance10.1101/2020.01.20.912303v1 · Melnikov, S. V., Stevens, D. L., Fu, X. et al.2020 · 0 citationsbioRxiv
Archaeal Ribosomal Proteins Possess Nuclear Localization Signal-Type Motifs: Implications for the Origin of the Cell Nucleus.31501901 · Melnikov, Sergey, Kwok, Hui-Si, Manakongtreecheep, Kasidet et al.2020 · 24 citationsMolecular biology and evolution. 2020;37(1):124-133
Aminoacyl-tRNA Synthetases and tRNAs for an Expanded Genetic Code: What Makes them Orthogonal?31010123 · Melnikov, Sergey V, Söll, Dieter2019 · 41 citationsInternational journal of molecular sciences. 2019;20(8)
Engineered Aminoacyl-tRNA Synthetases with Improved Selectivity toward Noncanonical Amino Acids.30933556 · Kwok, Hui Si, Vargas-Rodriguez, Oscar, Melnikov, Sergey V et al.2019 · 25 citationsACS chemical biology. 2019;14(4):603-612
Mechanistic insights into the slow peptide bond formation with D-amino acids in the ribosomal active site.30520988 · Melnikov, Sergey V, Khabibullina, Nelli F, Mairhofer, Elisabeth et al.2019 · 48 citationsNucleic acids research. 2019;47(4):2089-2100
Muller's Ratchet and Ribosome Degeneration in the Obligate Intracellular Parasites Microsporidia.30572624 · Melnikov, Sergey V, Manakongtreecheep, Kasidet, Rivera, Keith D et al.2019 · 29 citationsInternational journal of molecular sciences. 2018;19(12)
Loss of protein synthesis quality control in host-restricted organisms.30455292 · Melnikov, Sergey V, van den Elzen, Antonia, Stevens, David L et al.2019 · 30 citationsProceedings of the National Academy of Sciences of the United States of America. 2018;115(49):E11505-E11512
Revising the Structural Diversity of Ribosomal Proteins Across the Three Domains of Life.29529322 · Melnikov, Sergey, Manakongtreecheep, Kasidet, Söll, Dieter2019 · 90 citationsMolecular biology and evolution. 2018;35(7):1588-1598
Error-prone protein synthesis in parasites with the smallest eukaryotic genome.29915081 · Melnikov, Sergey V, Rivera, Keith D, Ostapenko, Denis et al.2018 · 35 citationsProceedings of the National Academy of Sciences of the United States of America. 2018;115(27):E6245-E6253
Structural Insights into the Role of Diphthamide on Elongation Factor 2 in mRNA Reading-Frame Maintenance.29886014 · Pellegrino, Simone, Demeshkina, Natalia, Mancera-Martinez, Eder et al.2019 · 63 citationsJournal of molecular biology. 2018;430(17):2677-2687
Molecular insights into protein synthesis with proline residues.27827794 · Melnikov, Sergey, Mailliot, Justine, Rigger, Lukas et al.2017 · 124 citationsEMBO reports. 2016;17(12):1776-1784
Crystal Structure of Hypusine-Containing Translation Factor eIF5A Bound to a Rotated Eukaryotic Ribosome.27196944 · Melnikov, Sergey, Mailliot, Justine, Shin, Byung-Sik et al.2017 · 68 citationsJournal of molecular biology. 2016;428(18):3570-3576
Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome.27079977 · Melnikov, Sergey V, Söll, Dieter, Steitz, Thomas A et al.2017 · 87 citationsNucleic acids research. 2016;44(10):4978-87
Insights into the origin of the nuclear localization signals in conserved ribosomal proteins.26066547 · Melnikov, Sergey, Ben-Shem, Adam, Yusupova, Gulnara et al.2016 · 32 citationsNature communications. 2015;6:7382
Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly.25775268 · Polikanov, Yury S, Melnikov, Sergey V, Söll, Dieter et al.2015 · 273 citationsNature structural & molecular biology. 2015;22(4):342-344
Crystal structure of the 80S yeast ribosome.22884264 · Jenner, Lasse, Melnikov, Sergey, Garreau de Loubresse, Nicolas et al.2013 · 140 citationsCurrent opinion in structural biology. 2012;22(6):759-67
One core, two shells: bacterial and eukaryotic ribosomes.22664983 · Melnikov, Sergey, Ben-Shem, Adam, Garreau de Loubresse, Nicolas et al.2012 · 476 citationsNature structural & molecular biology. 2012;19(6):560-7
The structure of the eukaryotic ribosome at 3.0 Å resolution.22096102 · Ben-Shem, Adam, Garreau de Loubresse, Nicolas, Melnikov, Sergey et al.2012 · 1,135 citationsScience (New York, N.Y.). 2011;334(6062):1524-9
[Influence of prothymosin alpha and its mutants on activity of the p53 tumor suppressor].18856068 · Zakharova, N I, Sokolov, V V, Rud'ko, V V et al.2008 · 0 citationsMolekuliarnaia biologiia. 2008;42(4):673-84
[Prothyomosin alpha interaction with KEAP1 doesn't lead to prothymosin alpha ubiquination and degradation].18240569 · Mel'nikov, S V, Evstaf'eva, A G, Vartapetian, A B2008 · 2 citationsMolekuliarnaia biologiia. 2007;41(5):868-75
[Novel functions of the well-known protein--prothymosin alpha is involved in protection of cells against apoptosis and oxidative stress].16240708 · Evstaf'eva, A G, Karapetian, R N, Rubtsov, Iu P et al.2005 · 1 citationMolekuliarnaia biologiia. 2005;39(5):729-45
Nuclear oncoprotein prothymosin alpha is a partner of Keap1: implications for expression of oxidative stress-protecting genes.15657435 · Karapetian, Ruben N, Evstafieva, Alexandra G, Abaeva, Irina S et al.2005 · 173 citationsMolecular and cellular biology. 2005;25(3):1089-99
Career total: 99 works. 42 are in this corpus.
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