JH
Joseph B. Hiatt
CRISPRHIV-1HIV InfectionsCRISPR-Cas SystemsgeneticsHIVImmune EvasionimmunologymicrobiologyProtein Interaction Maps
On Valency
published · living versionsW_26xzgw86·v1 · currentpublished
Assemblathon 2: evaluating de novo methods of genome assembly in three vertebrate species
with Keith R. Bradnam, Joseph N. Fass, Anton Alexandrov, Paul Baranay +86
1 version
Preprints & journals
32 papers in the corpus · 2009–2026Systematic discovery of pro- and anti-HIV host factors in primary human CD4+ T cells.42013838 · Rathore, Ujjwal, Dugan, Eli, Thornton, Hunter et al.2026 · 3 citationsCell. 2026;189(12):3651-3668.e31
CRISPR-Cas9 screen of E3 ubiquitin ligases identifies TRAF2 and UHRF1 as regulators of HIV latency in primary human T cells.38411080 · Rathore, Ujjwal, Haas, Paige, Easwar Kumar, Vigneshwari et al.2024 · 10 citationsmBio. 2024;15(4):e0222223
Publisher Correction: Evolution of enhanced innate immune evasion by SARS-CoV-2.35332335 · Thorne, Lucy G, Bouhaddou, Mehdi, Reuschl, Ann-Kathrin et al.2025 · 11 citationsNature. 2022;604(7905):E14
A functional map of HIV-host interactions in primary human T cells.35365639 · Hiatt, Joseph, Hultquist, Judd F, McGregor, Michael J et al.2022 · 52 citationsNature communications. 2022;13(1):1752
Evolution of enhanced innate immune evasion by SARS-CoV-2.34942634 · Thorne, Lucy G, Bouhaddou, Mehdi, Reuschl, Ann-Kathrin et al.2022 · 371 citationsNature. 2022;602(7897):487-495
Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant.34127972 · Thorne, Lucy G, Bouhaddou, Mehdi, Reuschl, Ann-Kathrin et al.2025 · 91 citationsbioRxiv : the preprint server for biology. 2021
Efficient generation of isogenic primary human myeloid cells using CRISPR-Cas9 ribonucleoproteins.33979618 · Hiatt, Joseph, Cavero, Devin A, McGregor, Michael J et al.2022 · 50 citationsCell reports. 2021;35(6):109105
TCF-1 regulates HIV-specific CD8+ T cell expansion capacity.33351785 · Rutishauser, Rachel L, Deguit, Christian Deo T, Hiatt, Joseph et al.2021 · 90 citationsJCI insight. 2021;6(3)
Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant.33501437 · Reuschl, Ann-Kathrin, Thorne, Lucy G, Zuliani-Alvarez, Lorena et al.2026 · 38 citationsbioRxiv : the preprint server for biology. 2021
Relationship between CD4 T cell turnover, cellular differentiation and HIV persistence during ART.33465157 · Bacchus-Souffan, Charline, Fitch, Mark, Symons, Jori et al.2021 · 47 citationsPLoS pathogens. 2021;17(1):e1009214
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.33060197 · Gordon, David E, Hiatt, Joseph, Bouhaddou, Mehdi et al.2020 · 750 citationsScience (New York, N.Y.). 2020;370(6521)
The Global Phosphorylation Landscape of SARS-CoV-2 Infection.32645325 · Bouhaddou, Mehdi, Memon, Danish, Meyer, Bjoern et al.2020 · 1,025 citationsCell. 2020;182(3):685-712.e19
Test performance evaluation of SARS-CoV-2 serological assays.32511497 · Whitman, Jeffrey D, Hiatt, Joseph, Mowery, Cody T et al.2025 · 455 citationsmedRxiv : the preprint server for health sciences. 2020
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.32353859 · Gordon, David E, Jang, Gwendolyn M, Bouhaddou, Mehdi et al.2020 · 4,392 citationsNature. 2020;583(7816):459-468
Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies.32302591 · Roth, Theodore L, Li, P Jonathan, Blaeschke, Franziska et al.2021 · 186 citationsCell. 2020;181(3):728-744.e21
Cyclophilin A Prevents HIV-1 Restriction in Lymphocytes by Blocking Human TRIM5α Binding to the Viral Core.32187548 · Selyutina, Anastasia, Persaud, Mirjana, Simons, Lacy M et al.2021 · 94 citationsCell reports. 2020;30(11):3766-3777.e6
TCF-1 regulates the stem-like memory potential of HIV-specific CD8+ T cells in elite controllers10.1101/2020.01.07.894535v1 · Rutishauser, R. L., Deguit, C. D. T., Hiatt, J. et al.2020 · 4 citationsbioRxiv
Large dataset enables prediction of repair after CRISPR-Cas9 editing in primary T cells.31359007 · Leenay, Ryan T, Aghazadeh, Amirali, Hiatt, Joseph et al.2019 · 133 citationsNature biotechnology. 2019;37(9):1034-1037
ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection.31253590 · Hüttenhain, Ruth, Xu, Jiewei, Burton, Lily A et al.2019 · 66 citationsCell host & microbe. 2019;26(1):86-99.e7
CRISPR-Cas9 genome engineering of primary CD4+ T cells for the interrogation of HIV-host factor interactions.30559373 · Hultquist, Judd F, Hiatt, Joseph, Schumann, Kathrin et al.2019 · 127 citationsNature protocols. 2019;14(1):1-27
Systematic characterization of genome editing in primary T cells reveals proximal genomic insertions and enables machine learning prediction of CRISPR-Cas9 DNA repair outcomes10.1101/404947v1 · Leenay, R. T., Aghazadeh, A., Hiatt, J. et al.2018 · 8 citationsbioRxiv
CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling.30166453 · Chen, Si-Han, Jang, Gwendolyn M, Hüttenhain, Ruth et al.2019 · 23 citationsThe EMBO journal. 2018;37(18)
Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to α4β7.30153309 · Lertjuthaporn, Sakaorat, Cicala, Claudia, Van Ryk, Donald et al.2019 · 34 citationsPLoS pathogens. 2018;14(8):e1007278
Reprogramming human T cell function and specificity with non-viral genome targeting.29995861 · Roth, Theodore L, Puig-Saus, Cristina, Yu, Ruby et al.2019 · 837 citationsNature. 2018;559(7714):405-409
MAdCAM costimulation through Integrin-α4β7 promotes HIV replication.29875402 · Nawaz, Fatima, Goes, Livia R, Ray, Jocelyn C et al.2019 · 31 citationsMucosal immunology. 2018;11(5):1342-1351
Light-activated cell identification and sorting (LACIS) for selection of edited clones on a nanofluidic device.30271925 · Mocciaro, Annamaria, Roth, Theodore L, Bennett, Hayley M et al.2020 · 50 citationsCommunications biology. 2018;1:41
A CRISPR-Cas9 Genome Engineering Platform in Primary CD4+ T Cells for the Interrogation of HIV Host Factors10.1101/205500v1 · Hultquist, J. F., Hiatt, J., Schumann, K. et al.2017 · 2 citationsbioRxiv
Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection.25419708 · Byrareddy, Siddappa N, Kallam, Brianne, Arthos, James et al.2015 · 142 citationsNature medicine. 2014;20(12):1397-400
The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression.24162774 · Jelicic, Katija, Cimbro, Raffaello, Nawaz, Fatima et al.2014 · 95 citationsNature immunology. 2013;14(12):1256-65
Assemblathon 2: evaluating de novo methods of genome assembly in three vertebrate species.23870653 · Bradnam, Keith R, Fass, Joseph N, Alexandrov, Anton et al.2014 · 671 citationsGigaScience. 2013;2(1):10
Evidence for compensatory upregulation of expressed X-linked genes in mammals, Caenorhabditis elegans and Drosophila melanogaster.22019781 · Deng, Xinxian, Hiatt, Joseph B, Nguyen, Di Kim et al.2012 · 286 citationsNature genetics. 2011;43(12):1179-85
The integrin alpha4beta7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1.19933330 · Cicala, Claudia, Martinelli, Elena, McNally, Jonathan P et al.2010 · 286 citationsProceedings of the National Academy of Sciences of the United States of America. 2009;106(49):20877-82
Career total: 39 works. 32 are in this corpus.
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