TK
Thomas Kolbe
Immunity, InnateSurgical Meshbiophysicscell biologyCell-free fetal DNADisease Models, AnimalEmbryo, MammalianmouseNon-invasive prenatal testingPregnancy-associated progenitor cells
On Valency
published · living versionsW_fgs3n2ts·v1 · currentpublished
Stochastic modelling, Bayesian inference, and new in vivo measurements elucidate the debated mtDNA bottleneck mechanism
with Iain G. Johnston, Joerg P. Burgstaller, Vitezslav Havlicek, Thomas Rulicke +3
1 version
Preprints & journals
69 papers in the corpus · 1991–2026Pro- and Anti-Inflammatory Macrophages Adjust UCP2 Protein Levels Based on Their Intrinsic Metabolism and Available Metabolites.42261610 · Nasirzade, Jila, Sternberg, Felix, Vogel, Andrea et al.2026 · 0 citationsEuropean journal of immunology. 2026;56(6):e70218
Cutaneous gain-of-function mutation of LRIG3 leads to alopecia by upregulation of ERBB, PI3K/AKT, NOTCH1 signaling pathways.42218262 · Ghorbanalipoor, Saeedeh, Hösl, Christine, Kolbe, Thomas et al.2026 · 0 citationsScientific reports. 2026;16(1)
tRNA thiolation defects disrupt cellular proteostasis and tissue homeostasis in mammals10.1101/2025.10.24.684405v1 · Englmaier, L., Walczak, M., Malzl, D. et al.2025 · 0 citationsbioRxiv
A survey on the implementation of environmental health monitoring in mouse facilities in German-speaking countries.41129528 · Mahabir, Esther, Schmidt, Katja, Kolbe, Thomas et al.2025 · 0 citationsPloS one. 2025;20(10):e0334442
Understanding Influenza A Virus Particles Detaching from Reconstructed Cell Surfaces.41071005 · Kolbe, Thomas, Gaspard, Pierre, Mognetti, Bortolo Matteo2025 · 2 citationsNano letters. 2025;25(42):15340-15345
Sequential PIDD1 auto-processing is essential for ploidy control in liver and heart10.1101/2025.06.23.660994v1 · Eichin, F., Sladky, V. C., Reiner, M. et al.2025 · 3 citationsbioRxiv
The loss of keratin 77 in murine skin is functionally compensated by keratin 1.39603462 · Ghorbanalipoor, S, Hommel, T, Kolbe, T et al.2025 · 2 citationsBiochimica et biophysica acta. Molecular cell research. 2025;1872(2):119881
Epigenetic inheritance of diet-induced and sperm-borne mitochondrial RNAs.38839949 · Tomar, A, Gomez-Velazquez, M, Gerlini, R et al.2024 · 212 citationsNature. 2024;630(8017):720-727
Inducible overexpression of a FAM3C/ILEI transgene has pleiotropic effects with shortened life span, liver fibrosis and anemia in mice.37713409 · Schmidt, Ulrike, Uluca, Betül, Vokic, Iva et al.2023 · 4 citationsPloS one. 2023;18(9):e0286256
Comparison of unilateral and bilateral embryo transfer in mice.36734260 · Auer, Kerstin E, Kolbe, Thomas, Laschalt, Claudia et al.2023 · 1 citationLaboratory animals. 2023;57(4):424-431
Effect of Different Ambient Temperatures on Reproductive Outcome and Stress Level of Lactating Females in Two Mouse Strains.36009730 · Kolbe, Thomas, Lassnig, Caroline, Poelzl, Andrea et al.2022 · 8 citationsAnimals : an open access journal from MDPI. 2022;12(16)
Effect of different ambient temperatures on reproductive outcome and wellbeing of lactating females in two mouse strains10.1101/2021.10.15.464536v1 · Kolbe, T., Lassnig, C., Poelzl, A. et al.2021 · 0 citationsbioRxiv
Amniotic fluid stem cells and the cell source repertoire for non-invasive prenatal testing.34383184 · Rosner, Margit, Kolbe, Thomas, Voronin, Viktor et al.2022 · 3 citationsStem cell reviews and reports. 2022;18(4):1366-1371
Cell competition acts as a purifying selection to eliminate cells with mitochondrial defects during early mouse development.34253906 · Lima, Ana, Lubatti, Gabriele, Burgstaller, Jörg et al.2021 · 86 citationsNature metabolism. 2021;3(8):1091-1108
Fetomaternal microchimerism and genetic diagnosis: On the origins of fetal cells and cell-free fetal DNA in the pregnant woman.34893150 · Rosner, Margit, Kolbe, Thomas, Hengstschläger, Markus2021 · 18 citationsMutation research. Reviews in mutation research. 2021;788:108399
Cytoplasmic Transfer Methods for Studying the Segregation of Mitochondrial DNA in Mice.34080146 · Kolbe, Thomas, Steinborn, Ralf, Burgstaller, Joerg P2021 · 2 citationsMethods in molecular biology (Clifton, N.J.). 2021;2277:91-99
Corrigendum to High Keratin 8/18 Ratio Predicts Aggressive Hepatocellular Cancer Phenotype12 [Translational Oncology Volume 12, Issue 2, February 2019, Pages 256-268].32081369 · Golob-Schwarzl, N, Bettermann, K, Mehta, A K et al.2020 · 0 citationsTranslational oncology. 2020;13(2):490-492
High activation of STAT5A drives peripheral T-cell lymphoma and leukemia.31123029 · Maurer, Barbara, Nivarthi, Harini, Wingelhofer, Bettina et al.2021 · 46 citationsHaematologica. 2020;105(2):435-447
Influence of graft size, histocompatibility,and cryopreservation on reproductive outcome following ovary transplantation in mice.31741257 · Kolbe, T, Walter, I, Rülicke, T2020 · 5 citationsJournal of assisted reproduction and genetics. 2019;36(12):2583-2591
NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial Immunity.30718299 · Simonović, Natalija, Witalisz-Siepracka, Agnieszka, Meissl, Katrin et al.2020 · 17 citationsJournal of immunology (Baltimore, Md. : 1950). 2019;202(6):1724-1734
High Keratin 8/18 Ratio Predicts Aggressive Hepatocellular Cancer Phenotype.30439626 · Golob-Schwarzl, Nicole, Bettermann, Kira, Mehta, Anita Kuldeep et al.2020 · 36 citationsTranslational oncology. 2019;12(2):256-268
Large-scale genetic analysis reveals mammalian mtDNA heteroplasmy dynamics and variance increase through lifetimes and generations.29950599 · Burgstaller, Joerg P, Kolbe, Thomas, Havlicek, Vitezslav et al.2019 · 68 citationsNature communications. 2018;9(1):2488
Aggressive B-cell lymphomas in patients with myelofibrosis receiving JAK1/2 inhibitor therapy.29907599 · Porpaczy, Edit, Tripolt, Sabrina, Hoelbl-Kovacic, Andrea et al.2019 · 151 citationsBlood. 2018;132(7):694-706
STAT5BN642H is a driver mutation for T cell neoplasia.29200404 · Pham, Ha Thi Thanh, Maurer, Barbara, Prchal-Murphy, Michaela et al.2019 · 86 citationsThe Journal of clinical investigation. 2018;128(1):387-401
Impact of superovulation and mating on the wellbeing of juvenile and adult C57BL/6N mice.25515937 · Kolbe, Thomas, Sheety, Sarjoun, Walter, Ingrid et al.2018 · 16 citationsReproduction, fertility, and development. 2016;28(7):969-973
Productivity of superovulated C57BL/6J oocyte donors at different ages.26300094 · Kolbe, Thomas, Landsberger, Adrian, Manz, Sabine et al.2016 · 10 citationsLab animal. 2015;44(9):346-9
Lifetime Dependent Variation of Stress Hormone Metabolites in Feces of Two Laboratory Mouse Strains.26284365 · Kolbe, Thomas, Palme, Rupert, Tichy, Alexander et al.2016 · 29 citationsPloS one. 2015;10(8):e0136112
Stochastic modelling, Bayesian inference, and new in vivo measurements elucidate the debated mtDNA bottleneck mechanism.26035426 · Johnston, Iain G, Burgstaller, Joerg P, Havlicek, Vitezslav et al.2016 · 93 citationseLife. 2015;4:e07464
Cytoplasmic transfer methods for studying the segregation of mitochondrial DNA in mice.25634287 · Kolbe, Thomas, Steinborn, Ralf, Burgstaller, Joerg P2015 · 0 citationsMethods in molecular biology (Clifton, N.J.). 2015;1265:357-65
MtDNA segregation in heteroplasmic tissues is common in vivo and modulated by haplotype differences and developmental stage.24910436 · Burgstaller, Joerg Patrick, Johnston, Iain G, Jones, Nick S et al.2015 · 104 citationsCell reports. 2014;7(6):2031-2041
STAT1β is not dominant negative and is capable of contributing to gamma interferon-dependent innate immunity.24710278 · Semper, Christian, Leitner, Nicole R, Lassnig, Caroline et al.2014 · 41 citationsMolecular and cellular biology. 2014;34(12):2235-48
Conditional ablation of TYK2 in immunity to viral infection and tumor surveillance.24696087 · Vielnascher, Raimund M, Hainzl, Eva, Leitner, Nicole R et al.2014 · 20 citationsTransgenic research. 2014;23(3):519-29
Inducible, dose-adjustable and time-restricted reconstitution of STAT1 deficiency in vivo.24489749 · Leitner, Nicole R, Lassnig, Caroline, Rom, Rita et al.2014 · 12 citationsPloS one. 2014;9(1):e86608
A mouse model to identify cooperating signaling pathways in cancer.22863881 · Musteanu, Monica, Blaas, Leander, Zenz, Rainer et al.2012 · 18 citationsNature methods. 2012;9(9):897-900
Genetic background effects of keratin 8 and 18 in a DDC-induced hepatotoxicity and Mallory-Denk body formation mouse model.22449798 · Haybaeck, Johannes, Stumptner, Cornelia, Thueringer, Andrea et al.2012 · 42 citationsLaboratory investigation; a journal of technical methods and pathology. 2012;92(6):857-67
Growth-hormone-induced signal transducer and activator of transcription 5 signaling causes gigantism, inflammation, and premature death but protects mice from aggressive liver cancer.22031092 · Friedbichler, Katrin, Themanns, Madeleine, Mueller, Kristina M et al.2012 · 48 citationsHepatology (Baltimore, Md.). 2012;55(3):941-52
Repeated use of surrogate mothers for embryo transfer in the mouse.21880946 · Kolbe, Thomas, Palme, Rupert, Touma, Chadi et al.2012 · 22 citationsBiology of reproduction. 2012;86(1):1-6
TYK2 kinase activity is required for functional type I interferon responses in vivo.22723949 · Prchal-Murphy, Michaela, Semper, Christian, Lassnig, Caroline et al.2012 · 72 citationsPloS one. 2012;7(6):e39141
Putting the brakes on mammary tumorigenesis: loss of STAT1 predisposes to intraepithelial neoplasias.22185785 · Schneckenleithner, Christine, Bago-Horvath, Zsuzsanna, Dolznig, Helmut et al.2012 · 44 citationsOncotarget. 2011;2(12):1043-54
ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1.21857651 · Haemmerle, Guenter, Moustafa, Tarek, Woelkart, Gerald et al.2011 · 764 citationsNature medicine. 2011;17(9):1076-85
A comparative proteome analysis links tyrosine kinase 2 (Tyk2) to the regulation of cellular glucose and lipid metabolism in response to poly(I:C).21787891 · Grunert, Tom, Leitner, Nicole R, Marchetti-Deschmann, Martina et al.2012 · 21 citationsJournal of proteomics. 2011;74(12):2866-80
Generation of mice with a conditional Stat1 null allele.21553074 · Wallner, Barbara, Leitner, Nicole R, Vielnascher, Raimund M et al.2012 · 31 citationsTransgenic research. 2012;21(1):217-24
A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK-cell survival and development.21127177 · Eckelhart, Eva, Warsch, Wolfgang, Zebedin, Eva et al.2011 · 223 citationsBlood. 2011;117(5):1565-73
Molecular analysis of clonal trichomonad isolates indicate the existence of heterogenic species present in different birds and within the same host.20471174 · Grabensteiner, Elvira, Bilic, Ivana, Kolbe, Thomas et al.2010 · 83 citationsVeterinary parasitology. 2010;172(1-2):53-64
Tensile strength and adhesion formation of mesh fixation systems used in laparoscopic incisional hernia repair.20033724 · Hollinsky, Christian, Kolbe, Thomas, Walter, Ingrid et al.2010 · 66 citationsSurgical endoscopy. 2010;24(6):1318-24
Dendritic cells require STAT-1 phosphorylated at its transactivating domain for the induction of peptide-specific CTL.19620292 · Pilz, Andreas, Kratky, Wolfgang, Stockinger, Silvia et al.2009 · 35 citationsJournal of immunology (Baltimore, Md. : 1950). 2009;183(4):2286-93
Influence of a new self-gripping hernia mesh on male fertility in a rat model.19572177 · Kolbe, Thomas, Hollinsky, Christian, Walter, Ingrid et al.2010 · 28 citationsSurgical endoscopy. 2010;24(2):455-61
Comparison of a new self-gripping mesh with other fixation methods for laparoscopic hernia repair in a rat model.19476899 · Hollinsky, Christian, Kolbe, Thomas, Walter, Ingrid et al.2009 · 57 citationsJournal of the American College of Surgeons. 2009;208(6):1107-14
The transcriptional regulator PLZF induces the development of CD44 high memory phenotype T cells.19004789 · Raberger, Julia, Schebesta, Alexandra, Sakaguchi, Shinya et al.2008 · 80 citationsProceedings of the National Academy of Sciences of the United States of America. 2008;105(46):17919-24
The TSC-mTOR signaling pathway regulates the innate inflammatory response.18848473 · Weichhart, Thomas, Costantino, Giuseppina, Poglitsch, Marko et al.2008 · 802 citationsImmunity. 2008;29(4):565-77
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