AK

Aarti Krishnan

0000-0002-7936-4442

Anti-Bacterial AgentsToxoplasma gondiiDeep LearningDrug DiscoveryToxoplasmaApicomplexamachine learningantibioticsDrug Designdrug discovery

On Valency

published · living versions

MoLRSI: A Recursive Self-Improving AI agent for Molecular Discovery

with Yikun Zhang, Xiwei Cheng, Mingze Yuan, Yu Zhang +13

1 version

W_ka3rjr2vv1 · current

Preprints & journals

25 papers in the corpus · 2016–2026

From code to cure: Harnessing AI for antibiotic discovery and design.

Krishnan, Aarti, Cao, Hanqun, Collins, James J et al.

0 citations

428738982026Science translational medicine. 2026;18(871):eaee4629

Deep learning-enabled discovery of antibiotics effective against Neisseria gonorrhoeae.

Anahtar, Melis N, Valeri, Jacqueline A, Modaresi, Seyed Majed et al.

5 citations

423083302026Science translational medicine. 2026;18(854):eads4699

FlashBind: Towards Accurate and Efficient Structure-based Virtual Screening

Jiang, S., Chen, Y., Krishnan, A. et al.

0 citations

10.64898/2025.12.22.695983v32025bioRxiv

Accelerating Scientific Discovery with Autonomous Goal-evolving Agents

Yuanqi Du, Botao Yu, Tianyu Liu et al.

1 citation

2512.21782v22025arXiv

A generative deep learning approach to de novo antibiotic design.

Krishnan, Aarti, Anahtar, Melis N, Valeri, Jacqueline A et al.

102 citations

408162672025Cell. 2025;188(21):5962-5979.e22

Active on demand: A precision prodrug strategy against drug-resistant Gram-negative pathogens.

Modaresi, Seyed Majed, Anahtar, Melis N, Krishnan, Aarti

3 citations

408121842025Cell host & microbe. 2025;33(8):1315-1317

An explainable deep learning platform for molecular discovery.

Wong, Felix, Omori, Satotaka, Li, Alicia et al.

29 citations

396538002025Nature protocols. 2025;20(4):1020-1056

Deep generative design of RNA aptamers using structural predictions.

Wong, Felix, He, Dongchen, Krishnan, Aarti et al.

86 citations

395060802024Nature computational science. 2024;4(11):829-839

Discovery of a structural class of antibiotics with explainable deep learning.

Wong, Felix, Zheng, Erica J, Valeri, Jacqueline A et al.

461 citations

381236862024Nature. 2024;626(7997):177-185

Discovery of antibiotics that selectively kill metabolically dormant bacteria.

Zheng, Erica J, Valeri, Jacqueline A, Andrews, Ian W et al.

56 citations

380297562024Cell chemical biology. 2024;31(4):712-728.e9

Gaming bacterial metabolism.

Valeri, Jacqueline A, Krishnan, Aarti, Collins, James J

1 citation

372687732023Nature microbiology. 2023;8(6):1004-1005

Dissection of Besnoitia besnoiti intermediate host life cycle stages: From morphology to gene expression.

Ramakrishnan, Chandra, Krishnan, Aarti, Francisco, Samuel et al.

11 citations

363953462022PLoS pathogens. 2022;18(11):e1010955

Benchmarking AlphaFold-enabled molecular docking predictions for antibiotic discovery.

Wong, Felix, Krishnan, Aarti, Zheng, Erica J et al.

283 citations

360658472022Molecular systems biology. 2022;18(9):e11081

Ceramide biosynthesis is critical for establishment of the intracellular niche of Toxoplasma gondii.

Nyonda, Mary Akinyi, Kloehn, Joachim, Sosnowski, Piotr et al.

38 citations

359774992022Cell reports. 2022;40(7):111224

N-acetylation of secreted proteins in Apicomplexa is widespread and is independent of the ER acetyl-CoA transporter AT1.

Nyonda, Mary Akinyi, Boyer, Jean-Baptiste, Belmudes, Lucid et al.

12 citations

356210492022Journal of cell science. 2022;135(15)

Toxoplasma gondii phosphatidylserine flippase complex ATP2B-CDC50.4 critically participates in microneme exocytosis.

Bisio, Hugo, Krishnan, Aarti, Marq, Jean-Baptiste et al.

35 citations

353250102022PLoS pathogens. 2022;18(3):e1010438

Pantothenate biosynthesis is critical for chronic infection by the neurotropic parasite Toxoplasma gondii.

Lunghi, Matteo, Kloehn, Joachim, Krishnan, Aarti et al.

31 citations

350394772022Nature communications. 2022;13(1):345

Revisiting the Role of Toxoplasma gondii ERK7 in the Maintenance and Stability of the Apical Complex.

Dos Santos Pacheco, Nicolas, Tosetti, Nicolò, Krishnan, Aarti et al.

35 citations

346074612022mBio. 2021;12(5):e0205721

Extensive regulation of enzyme activity by phosphorylation in Escherichia coli.

Schastnaya, Evgeniya, Raguz Nakic, Zrinka, Gruber, Christoph H et al.

48 citations

345614422021Nature communications. 2021;12(1):5650

Amino Acid Metabolism in Apicomplexan Parasites.

Krishnan, Aarti, Soldati-Favre, Dominique

49 citations

334983082024Metabolites. 2021;11(2)

Correction: Vitamin and cofactor acquisition in apicomplexans: Synthesis versus salvage.

Krishnan, Aarti, Kloehn, Joachim, Lunghi, Matteo et al.

0 citations

321981892021The Journal of biological chemistry. 2020;295(12):4064

Functional and Computational Genomics Reveal Unprecedented Flexibility in Stage-Specific Toxoplasma Metabolism.

Krishnan, Aarti, Kloehn, Joachim, Lunghi, Matteo et al.

109 citations

319910932020Cell host & microbe. 2020;27(2):290-306.e11

The Actomyosin Systems in Apicomplexa.

Frénal, Karine, Krishnan, Aarti, Soldati-Favre, Dominique

11 citations

324518652020Advances in experimental medicine and biology. 2020;1239:331-354

Vitamin and cofactor acquisition in apicomplexans: Synthesis versus salvage.

Krishnan, Aarti, Kloehn, Joachim, Lunghi, Matteo et al.

20 citations

317676802020The Journal of biological chemistry. 2020;295(3):701-714

Parasite pathogenesis: Breaching the wall for brain access.

Krishnan, Aarti, Soldati-Favre, Dominique

2 citations

275721732018Nature microbiology. 2016;1:16014

Career total: 42 works. 25 are in this corpus.

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