PJ
Patricia A. Jennings
Protein FoldingProtein ConformationModels, MolecularmitoNEETNEET proteinscancerCatalytic DomainMolecular Dynamics SimulationNAF-1Point Mutation
On Valency
published · living versionsW_zkn5w8bg·v1 · currentpublished
How native state topology affects the folding of Dihydrofolate Reductase and Interleukin-1beta
with Cecilia Clementi, Jose' N. Onuchic
1 version
Preprints & journals
149 papers in the corpus · 1991–2026Mutation-induced heme pocket destabilization in myoglobinopathy.42516268 · Kachhap, Sangita, Sturms, Ryan, Adepu, Kiran Kumar et al.2026 · 1 citationFrontiers in bioinformatics. 2026;6:1887793
1H, 13C, 15N backbone assignment of the minimally tied trefoil knot, MTTSA, a 23s rRNA SPOUT methyltransferase.41963736 · Tao, Tiange, Capraro, Dominique T, Jennings, Patricia A2026 · 0 citationsBiomolecular NMR assignments. 2026;20(1)
Disordered N-terminal region of CLK1 oligomerizes for recruitment to nuclear substructures and splicing function10.64898/2026.02.22.707342v1 · George, A., Fattet, L., Capraro, D. et al.2026 · 0 citationsbioRxiv
Csk αC Helix: A Computational Analysis of an Essential Region for Conformational Transitions.36512419 · Dias, Raphael Vinicius Rodrigues, Ferreira, Carolina Tatiani Alves, Jennings, Patricia Ann et al.2022 · 7 citationsThe journal of physical chemistry. B. 2022;126(50):10587-10596
Knotting Optimization and Folding Pathways of a Go-Model with a Deep Knot.36424347 · Dahlstrom, Thomas J, Capraro, Dominique T, Jennings, Particia A et al.2022 · 1 citationThe journal of physical chemistry. B. 2022;126(48):10221-10236
E-cigarette aerosol impairs male mouse skeletal muscle force development and prevents recovery from injury.36250633 · Nogueira, Leonardo, Zemljic-Harpf, Alice E, Yusufi, Raihana et al.2022 · 10 citationsAmerican journal of physiology. Regulatory, integrative and comparative physiology. 2022;323(6):R849-R860
A VDAC1-mediated NEET protein chain transfers [2Fe-2S] clusters between the mitochondria and the cytosol and impacts mitochondrial dynamics.35135884 · Karmi, Ola, Marjault, Henri-Baptiste, Bai, Fang et al.2022 · 50 citationsProceedings of the National Academy of Sciences of the United States of America. 2022;119(7)
IL-33/ST2 receptor-dependent signaling in the development of pulmonary hypertension in Sugen/hypoxia mice.35150208 · Indralingam, Cynthia S, Gutierrez-Gonzalez, Alma K, Johns, Scott C et al.2022 · 11 citationsPhysiological reports. 2022;10(3):e15185
Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly.33220177 · Chai, Guoliang, Webb, Alice, Li, Chen et al.2021 · 52 citationsNeuron. 2021;109(2):241-256.e9
Unraveling Allostery in a Knotted Minimal Methyltransferase by NMR Spectroscopy.32135193 · Capraro, Dominique T, Burban, David J, Jennings, Patricia A2020 · 6 citationsJournal of molecular biology. 2020;432(9):3018-3032
The Pierced Lasso Topology Leptin has a Bolt on Dynamic Domain Composed by the Disordered Loops I and III.32081588 · Danielsson, Jens, Noel, Jeffrey Kenneth, Simien, Jennifer Michelle et al.2020 · 11 citationsJournal of molecular biology. 2020;432(9):3050-3063
Cigarette Smoke Triggers IL-33-associated Inflammation in a Model of Late-Stage Chronic Obstructive Pulmonary Disease.30973786 · Lee, Jasmine H, Hailey, Kendra L, Vitorino, Steven A et al.2020 · 31 citationsAmerican journal of respiratory cell and molecular biology. 2019;61(5):567-574
Redox-dependent gating of VDAC by mitoNEET.31527235 · Lipper, Colin H, Stofleth, Jason T, Bai, Fang et al.2020 · 146 citationsProceedings of the National Academy of Sciences of the United States of America. 2019;116(40):19924-19929
The anti-apoptotic proteins NAF-1 and iASPP interact to drive apoptosis in cancer cells.30774867 · Iosub-Amir, Anat, Bai, Fang, Sohn, Yang-Sung et al.2024 · 13 citationsChemical science. 2019;10(3):665-673
Designing bacterial signaling interactions with coevolutionary landscapes.30125296 · Cheng, Ryan R, Haglund, Ellinor, Tiee, Nicholas S et al.2019 · 9 citationsPloS one. 2018;13(8):e0201734
Uncovering the molecular mechanisms behind disease-associated leptin variants.29950524 · Haglund, Ellinor, Nguyen, Lannie, Schafer, Nicholas Peter et al.2019 · 15 citationsThe Journal of biological chemistry. 2018;293(33):12919-12933
Broad-Spectrum Regulation of Nonreceptor Tyrosine Kinases by the Bacterial ADP-Ribosyltransferase EspJ.29636436 · Pollard, Dominic J, Berger, Cedric N, So, Ernest C et al.2019 · 19 citationsmBio. 2018;9(2)
NEET Proteins: A New Link Between Iron Metabolism, Reactive Oxygen Species, and Cancer.29463105 · Mittler, Ron, Darash-Yahana, Merav, Sohn, Yang Sung et al.2020 · 186 citationsAntioxidants & redox signaling. 2019;30(8):1083-1095
Phylogenetic analysis of the CDGSH iron-sulfur binding domain reveals its ancient origin.29556009 · Sengupta, Soham, Nechushtai, Rachel, Jennings, Patricia A et al.2019 · 24 citationsScientific reports. 2018;8(1):4840
The unique fold and lability of the [2Fe-2S] clusters of NEET proteins mediate their key functions in health and disease.29435647 · Karmi, Ola, Marjault, Henri-Baptiste, Pesce, Luca et al.2019 · 74 citationsJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. 2018;23(4):599-612
Structure of the human monomeric NEET protein MiNT and its role in regulating iron and reactive oxygen species in cancer cells.29259115 · Lipper, Colin H, Karmi, Ola, Sohn, Yang Sung et al.2018 · 82 citationsProceedings of the National Academy of Sciences of the United States of America. 2018;115(2):272-277
Molecular Dynamics Simulations of the [2Fe-2S] Cluster-Binding Domain of NEET Proteins Reveal Key Molecular Determinants That Induce Their Cluster Transfer/Release.29086562 · Pesce, Luca, Calandrini, Vania, Marjault, Henri-Baptiste et al.2018 · 26 citationsThe journal of physical chemistry. B. 2017;121(47):10648-10656
Redirecting SR Protein Nuclear Trafficking through an Allosteric Platform.28576472 · Aubol, Brandon E, Hailey, Kendra L, Fattet, Laurent et al.2017 · 32 citationsJournal of molecular biology. 2017;429(14):2178-2191
Interactions between mitoNEET and NAF-1 in cells.28426722 · Karmi, Ola, Holt, Sarah H, Song, Luhua et al.2017 · 55 citationsPloS one. 2017;12(4):e0175796
Guiding the design of bacterial signaling interactions using a coevolutionary landscape10.1101/116947v2 · Cheng, R. R., Haglund, E., Tiee, N. et al.2017 · 2 citationsbioRxiv
Backbone assignments for the SPOUT methyltransferase MTT Tm , a knotted protein from Thermotoga maritima.28284017 · Burban, David J, Jennings, Patricia A2018 · 2 citationsBiomolecular NMR assignments. 2017;11(2):151-154
Phylogenetic analysis of eukaryotic NEET proteins uncovers a link between a key gene duplication event and the evolution of vertebrates.28205535 · Inupakutika, Madhuri A, Sengupta, Soham, Nechushtai, Rachel et al.2018 · 57 citationsScientific reports. 2017;7:42571
Pierced Lasso Topology Controls Function in Leptin.28035835 · Haglund, Ellinor, Pilko, Anna, Wollman, Roy et al.2018 · 27 citationsThe journal of physical chemistry. B. 2017;121(4):706-718
Breast cancer tumorigenicity is dependent on high expression levels of NAF-1 and the lability of its Fe-S clusters.27621439 · Darash-Yahana, Merav, Pozniak, Yair, Lu, Mingyang et al.2018 · 81 citationsProceedings of the National Academy of Sciences of the United States of America. 2016;113(39):10890-5
Gambogic acid identifies an isoform-specific druggable pocket in the middle domain of Hsp90β.27466407 · Yim, Kendrick H, Prince, Thomas L, Qu, Shiwei et al.2018 · 66 citationsProceedings of the National Academy of Sciences of the United States of America. 2016;113(33):E4801-9
Untangling the Influence of a Protein Knot on Folding.26958882 · Capraro, Dominique T, Jennings, Patricia A2016 · 26 citationsBiophysical journal. 2016;110(5):1044-51
Geometrical Frustration in Interleukin-33 Decouples the Dynamics of the Functional Element from the Folding Transition State Ensemble.26630011 · Fisher, Kaitlin M, Haglund, Ellinor, Noel, Jeffrey K et al.2016 · 10 citationsPloS one. 2015;10(12):e0144067
Activation of apoptosis in NAF-1-deficient human epithelial breast cancer cells.26621032 · Holt, Sarah H, Darash-Yahana, Merav, Sohn, Yang Sung et al.2016 · 64 citationsJournal of cell science. 2016;129(1):155-65
Cancer-Related NEET Proteins Transfer 2Fe-2S Clusters to Anamorsin, a Protein Required for Cytosolic Iron-Sulfur Cluster Biogenesis.26448442 · Lipper, Colin H, Paddock, Mark L, Onuchic, José N et al.2016 · 90 citationsPloS one. 2015;10(10):e0139699
Nuclear protein kinase CLK1 uses a non-traditional docking mechanism to select physiological substrates.26443864 · Keshwani, Malik M, Hailey, Kendra L, Aubol, Brandon E et al.2016 · 20 citationsThe Biochemical journal. 2015;472(3):329-38
Heterogeneous side chain conformation highlights a network of interactions implicated in hysteresis of the knotted protein, minimal tied trefoil.26291198 · Burban, David J, Haglund, Ellinor, Capraro, Dominique T et al.2016 · 14 citationsJournal of physics. Condensed matter : an Institute of Physics journal. 2015;27(35):354108
Correction: Theoretical Insights Reveal Novel Motions in Csk's SH3 Domain That Control Kinase Activation.26191813 · Barkho, Sulyman, Pierce, Levi C T, Li, Sheng et al.2016 · 0 citationsPloS one. 2015;10(7):e0133801
Dual-Mode HDAC Prodrug for Covalent Modification and Subsequent Inhibitor Release.25974739 · Daniel, Kevin B, Sullivan, Eric D, Chen, Yao et al.2015 · 39 citationsJournal of medicinal chemistry. 2015;58(11):4812-21
Theoretical Insights Reveal Novel Motions in Csk's SH3 Domain That Control Kinase Activation.26030592 · Barkho, Sulyman, Pierce, Levi C T, Li, Sheng et al.2016 · 3 citationsPloS one. 2015;10(6):e0127724
The Fe-S cluster-containing NEET proteins mitoNEET and NAF-1 as chemotherapeutic targets in breast cancer.25762074 · Bai, Fang, Morcos, Faruck, Sohn, Yang-Sung et al.2015 · 88 citationsProceedings of the National Academy of Sciences of the United States of America. 2015;112(12):3698-703
Conserved proline-directed phosphorylation regulates SR protein conformation and splicing function.25529026 · Keshwani, Malik M, Aubol, Brandon E, Fattet, Laurent et al.2015 · 57 citationsThe Biochemical journal. 2015;466(2):311-22
Structure-function analysis of NEET proteins uncovers their role as key regulators of iron and ROS homeostasis in health and disease.25448035 · Tamir, Sagi, Paddock, Mark L, Darash-Yahana-Baram, Merav et al.2015 · 192 citationsBiochimica et biophysica acta. 2015;1853(6):1294-315
Pierced Lasso Bundles are a new class of knot-like motifs.24945798 · Haglund, Ellinor, Sulkowska, Joanna I, Noel, Jeffrey K et al.2015 · 52 citationsPLoS computational biology. 2014;10(6):e1003613
A point mutation in the [2Fe-2S] cluster binding region of the NAF-1 protein (H114C) dramatically hinders the cluster donor properties.24914968 · Tamir, Sagi, Eisenberg-Domovich, Yael, Conlan, Andrea R et al.2015 · 39 citationsActa crystallographica. Section D, Biological crystallography. 2014;70(Pt 6):1572-8
Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1.24706857 · Tamir, Sagi, Rotem-Bamberger, Shahar, Katz, Chen et al.2014 · 61 citationsProceedings of the National Academy of Sciences of the United States of America. 2014;111(14):5177-82
Proximity-enabled protein crosslinking through genetically encoding haloalkane unnatural amino acids.24449339 · Xiang, Zheng, Lacey, Vanessa K, Ren, Haiyan et al.2014 · 121 citationsAngewandte Chemie (International ed. in English). 2014;53(8):2190-3
Altered backbone and side-chain interactions result in route heterogeneity during the folding of interleukin-1β (IL-1β).23972849 · Capraro, Dominique T, Lammert, Heiko, Heidary, David K et al.2014 · 6 citationsBiophysical journal. 2013;105(4):975-83
NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth.23959881 · Sohn, Yang-Sung, Tamir, Sagi, Song, Luhua et al.2013 · 217 citationsProceedings of the National Academy of Sciences of the United States of America. 2013;110(36):14676-81
Allosteric switching of agonist/antagonist activity by a single point mutation in the interluekin-1 receptor antagonist, IL-1Ra.23499887 · Hailey, Kendra L, Capraro, Dominique T, Barkho, Sulyman et al.2013 · 12 citationsJournal of molecular biology. 2013;425(13):2382-92
Learning from cancer how to defeat bacteria.23407166 · Onuchic, José N, Jennings, Patricia A, Ben-Jacob, Eshel2013 · 5 citationsProceedings of the National Academy of Sciences of the United States of America. 2013;110(9):3212-3
Career total: 222 works. 149 are in this corpus.Showing the 50 most recent.
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