CW
Christopher J. Welch
Supercritical fluid chromatographyHigh-throughput analysisMethod developmentChromatography, Supercritical FluidChiral separationsChromatographyComplex mixturesDrug DiscoveryHigh throughput analysisMultiple injections in a single experimental run
On Valency
published · living versionsW_f6w2p2ta·v1 · currentpublished
Can the analyte-triggered asymmetric autocatalytic Soai reaction serve as a universal analytical tool for measuring enantiopurity and assigning absolute configuration?
with Kerstin Zawatzky, Alexey A. Makarov, Satoshi Fujiwara, Arimasa Matsumoto +1
1 version
Preprints & journals
145 papers in the corpus · 1985–2026Drug Metabolism and Drug-Drug Interactions Studied Using High-Throughput Ambient Mass Spectrometry.42899528 · Saha, Mousumi, Talaty, Nari, Morato, Nicolás M et al.2026 · 0 citationsAnalytical chemistry. 2026;98(41):29604-29615
Interpretable machine learning-based automated HPLC/MS2 platform using ion-molecule reactions for the identification of functionalities in analytes.42388806 · Beck, Armen G, Anyaeche, Ruth O, Wijewardhane, Prageeth et al.2026 · 0 citationsChemical science. 2026;17(32):15371-15388
High-Throughput Reactive Desorption Electrospray Ionization Mass Spectrometry for Targeted Derivatization and Analysis of Poorly Ionized Small Molecules.42223360 · Feng, Yunfei, Chen, Kitmin, Huang, Kai-Hung et al.2026 · 0 citationsAnalytical chemistry. 2026;98(23):16962-16970
Interpretable Machine Learning-based Automated HPLC/MS2 Platform10.26434/chemrxiv-2025-qdpc8 · Armen Beck, Ruth Anyaeche, Prageeth Wijewardhane et al.2025 · 0 citationsChemRxiv
Instrument-agnostic Machine Learning Framework for Accurate Prediction of Functional Groups from Tandem Mass Spectrometry10.26434/chemrxiv-2025-px8nb · Connor Beveridge, Prageeth Wijewardhane, Matthew Muhoberac et al.2025 · 0 citationsChemRxiv
N-Nitrosamine Quantitation in Pharmaceuticals by Tandem Mass Spectrometry.40983981 · Saha, Mousumi, Qiu, Lingqi, Kraft, Stefan et al.2025 · 2 citationsAnalytical chemistry. 2025;97(39):21502-21507
A 'One-Shot' strategy for preparative chiral sub/supercritical fluid chromatography with chiroptical detection accelerates purification and enhances characterization for drug discovery.39892265 · Reilly, John, Lozach, Marie-Anne, Meishammer, Aldo et al.2025 · 4 citationsJournal of chromatography. A. 2025;1744:465720
Simultaneous Quantitation of Multiple Biological Thiols Using Reactive Ionization and Derivatization with Charged Mass Tags.39570044 · Saha, Mousumi, Qiu, Lingqi, Han-Hallett, Yu et al.2024 · 12 citationsAnalytical chemistry. 2024;96(49):19414-19421
Deep-Learning-Guided Electrochemical Impedance Spectroscopy for Calibration-Free Pharmaceutical Moisture Content Monitoring.39096505 · Han, Guangshuai, Maranzano, Brent, Welch, Christopher et al.2024 · 11 citationsACS sensors. 2024;9(8):4186-4195
Enhanced Structure-Based Prediction of Chiral Stationary Phases for Chromatographic Enantioseparation from 3D Molecular Conformations.38308813 · Hong, Yuhui, Welch, Christopher J, Piras, Patrick et al.2024 · 27 citationsAnalytical chemistry. 2024;96(6):2351-2359
Investigation into the performance and stability of immobilized and coated polysaccharide columns in supercritical fluid chromatography.37920131 · Yue, Lei, Yeh, Madeline, Reilly, John et al.2023 · 9 citationsChirality. 2024;36(1):e23626
Quantitative Determination of Water in Organic Liquids by Ambient Mass Spectrometry.37740943 · Qiu, Lingqi, Saha, Mousumi, Kraft, Stefan et al.2023 · 17 citationsAngewandte Chemie (International ed. in English). 2023;62(47):e202310884
3DMolMS: prediction of tandem mass spectra from 3D molecular conformations.37252828 · Hong, Yuhui, Li, Sujun, Welch, Christopher J et al.2023 · 34 citationsBioinformatics (Oxford, England). 2023;39(6)
Rapid Quantitation of Various Therapeutic Monoclonal Antibodies Using Membranes with Fc-Specific Ligands.37216615 · Yang, Junyan, Ostafe, Raluca, Welch, Christopher J et al.2023 · 4 citationsAnalytical chemistry. 2023;95(22):8541-8551
Microporous affinity membranes and their incorporation into microfluidic devices for monitoring of therapeutic antibodies.36030739 · Berwanger, Joshua D, Lake, Melinda A, Ganguly, Sanniv et al.2022 · 6 citationsTalanta. 2023;252:123842
Fragmentation of Polyfunctional Compounds Recorded Using Automated High-Throughput Desorption Electrospray Ionization.34280312 · Le, MyPhuong T, Morato, Nicolás M, Kaerner, Andreas et al.2021 · 15 citationsJournal of the American Society for Mass Spectrometry. 2021;32(8):2261-2273
High-Throughput Determination of Enantiopurity by Microplate Circular Dichroism.32705865 · Pilicer, Samantha L, Dragna, Justin M, Garland, Adam et al.2021 · 42 citationsThe Journal of organic chemistry. 2020;85(16):10858-10864
Next-Generation TLC: A Quantitative Platform for Parallel Spotting and Imaging.32559382 · Boulgakov, Alexander A, Moor, Sarah R, Jo, Hyun Hwa et al.2021 · 16 citationsThe Journal of organic chemistry. 2020;85(15):9447-9453
William H. Pirkle: Stereochemistry pioneer.32388884 · Welch, Christopher J2020 · 10 citationsChirality. 2020;32(7):961-974
Mass Activated Droplet Sorting (MADS) Enables High-Throughput Screening of Enzymatic Reactions at Nanoliter Scale.31868984 · Holland-Moritz, Daniel A, Wismer, Michael K, Mann, Benjamin F et al.2021 · 169 citationsAngewandte Chemie (International ed. in English). 2020;59(11):4470-4477
Optical Chirality Sensing with a Stereodynamic Aluminum Biphenolate Probe.30019902 · De Los Santos, Zeus A, Joyce, Leo A, Sherer, Edward C et al.2019 · 27 citationsThe Journal of organic chemistry. 2019;84(8):4639-4645
Mapping the dark space of chemical reactions with extended nanomole synthesis and MALDI-TOF MS.29794218 · Lin, Shishi, Dikler, Sergei, Blincoe, William D et al.2018 · 194 citationsScience (New York, N.Y.). 2018;361(6402)
Accelerated Forced Degradation of Pharmaceuticals in Levitated Microdroplet Reactors.29653016 · Li, Yangjie, Liu, Yong, Gao, Hong et al.2018 · 53 citationsChemistry (Weinheim an der Bergstrasse, Germany). 2018;24(29):7349-7353
Modeling and predicting chiral stationary phase enantioselectivity: An efficient random forest classifier using an optimally balanced training dataset and an aggregation strategy.29383846 · Piras, Patrick, Sheridan, Robert, Sherer, Edward C et al.2018 · 23 citationsJournal of separation science. 2018;41(6):1365-1375
Enabling Biocatalysis by High-Throughput Protein Engineering Using Droplet Microfluidics Coupled to Mass Spectrometry.30023807 · Diefenbach, Xue W, Farasat, Iman, Guetschow, Erik D et al.2020 · 110 citationsACS omega. 2018;3(2):1498-1508
Are We Approaching a Speed Limit for the Chromatographic Separation of Enantiomers?28852695 · Welch, Christopher J2020 · 45 citationsACS central science. 2017;3(8):823-829
An Asymmetric, Catalytic (4 + 3) Cycloaddition Reaction of Cyclopentenyl Oxyallylic Cations.28741952 · Topinka, Michael, Zawatzky, Kerstin, Barnes, Charles L et al.2018 · 39 citationsOrganic letters. 2017;19(15):4106-4109
Palladium-Catalyzed Enantioselective Arylation of Aryl Sulfenate Anions: A Combined Experimental and Computational Study.28537724 · Jia, Tiezheng, Zhang, Mengnan, McCollom, Samuel P et al.2018 · 92 citationsJournal of the American Chemical Society. 2017;139(24):8337-8345
Separation of small interfering RNA stereoisomers using reversed-phase ion-pairing chromatography.28449879 · Li, Li, Leone, Tony, Foley, Joe P et al.2017 · 38 citationsJournal of chromatography. A. 2017;1500:84-88
Overcoming "speed limits" in high throughput chromatographic analysis.28416217 · Zawatzky, Kerstin, Barhate, Chandan L, Regalado, Erik L et al.2017 · 49 citationsJournal of chromatography. A. 2017;1499:211-216
Effects of pressure and frictional heating on protein separation using monolithic columns in reversed-phase chromatography.28193469 · Mann, Benjamin F, Makarov, Alexey A, Wang, Heather et al.2017 · 7 citationsJournal of chromatography. A. 2017;1489:58-64
Assessment of coulometric array electrochemical detection coupled with HPLC-UV for the absolute quantitation of pharmaceuticals.28098264 · Hicks, Michael B, Salituro, Leah, Mangion, Ian et al.2018 · 10 citationsThe Analyst. 2017;142(3):525-536
Ultrafast Chiral Chromatography as the Second Dimension in Two-Dimensional Liquid Chromatography Experiments.28192943 · Barhate, Chandan L, Regalado, Erik L, Contrella, Nathan D et al.2019 · 120 citationsAnalytical chemistry. 2017;89(6):3545-3553
Unusual reversal of enantioselectivity in the asymmetric autocatalysis of pyrimidyl alkanol triggered by chiral aromatic alkanols and amines.27942665 · Matusmoto, Arimasa, Fujiwara, Satoshi, Hiyoshi, Yui et al.2018 · 27 citationsOrganic & biomolecular chemistry. 2017;15(3):555-558
Online sensing of palladium in flowing streams.27990538 · Bu, Xiaodong, Williams, Michael, Jo, Junyong et al.2018 · 18 citationsChemical communications (Cambridge, England). 2017;53(4):720-723
Ultrafast chiral separations for high throughput enantiopurity analysis.27872920 · Barhate, Chandan L, Joyce, Leo A, Makarov, Alexey A et al.2017 · 132 citationsChemical communications (Cambridge, England). 2017;53(3):509-512
Can the analyte-triggered asymmetric autocatalytic Soai reaction serve as a universal analytical tool for measuring enantiopurity and assigning absolute configuration?27714244 · Welch, Christopher J, Zawatzky, Kerstin, Makarov, Alexey A et al.2018 · 11 citationsOrganic & biomolecular chemistry. 2016;15(1):96-101
2D-LC as an on-line desalting tool allowing peptide identification directly from MS unfriendly HPLC methods.28113090 · Luo, Hao, Zhong, Wendy, Yang, Jiong et al.2017 · 25 citationsJournal of pharmaceutical and biomedical analysis. 2017;137:139-145
Mining Chromatographic Enantioseparation Data Using Matched Molecular Pair Analysis.27689987 · Sheridan, Robert P, Piras, Patrick, Sherer, Edward C et al.2020 · 9 citationsMolecules (Basel, Switzerland). 2016;21(10)
Visualizing small differences using subtractive chromatographic analysis.27663729 · Zawatzky, Kerstin, Reibarkh, Mikhail, Canfield, Nicole et al.2017 · 3 citationsJournal of chromatography. A. 2016;1468:245-249
Hydroxypyridyl Imines: Enhancing Chromatographic Separation and Stereochemical Analysis of Chiral Amines via Circular Dichroism.27529785 · Joyce, Leo A, Regalado, Erik L, Welch, Christopher J2018 · 16 citationsThe Journal of organic chemistry. 2016;81(18):8199-205
Using chromatogram averaging to improve quantitation of minor impurities.27578409 · Zawatzky, Kerstin, Lin, Mingxiang, Schafer, Wes et al.2017 · 5 citationsJournal of chromatography. A. 2016;1465:205-10
Multiple-injection high-throughput gas chromatography analysis.27292909 · Schafer, Wes, Wang, Heather, Welch, Christopher J2018 · 6 citationsJournal of separation science. 2016;39(15):2978-85
Evaluation of C18 monolithic columns for radiochemical purity measurement.27411721 · Schenk, David J, Welch, Christopher J, Antonucci, Vincent2017 · 3 citationsJournal of labelled compounds & radiopharmaceuticals. 2016;59(10):391-7
Using Electron Paramagnetic Resonance Spectroscopy To Facilitate Problem Solving in Pharmaceutical Research and Development.27322370 · Mangion, Ian, Liu, Yizhou, Reibarkh, Mikhail et al.2018 · 11 citationsThe Journal of organic chemistry. 2016;81(16):6937-44
Toward structure-based predictive tools for the selection of chiral stationary phases for the chromatographic separation of enantiomers.27318509 · Sheridan, Robert, Schafer, Wes, Piras, Patrick et al.2016 · 35 citationsJournal of chromatography. A. 2016;1467:206-213
Are fluorine-rich pharmaceuticals lost by partition into fluorous phases?27239759 · Sun, Shuwen, Zawatzky, Kerstin, Regalado, Erik L et al.2017 · 2 citationsJournal of pharmaceutical and biomedical analysis. 2016;128:106-110
Use of hydrostatic pressure for modulation of protein chemical modification and enzymatic selectivity.27088756 · Makarov, Alexey A, Helmy, Roy, Joyce, Leo et al.2018 · 5 citationsOrganic & biomolecular chemistry. 2016;14(19):4448-55
Expedited Selection of NMR Chiral Solvating Agents for Determination of Enantiopurity.27280168 · Yang, Lu, Wenzel, Thomas, Williamson, R Thomas et al.2016 · 76 citationsACS central science. 2016;2(5):332-40
A competitive and reversible deactivation approach to catalysis-based quantitative assays.26891765 · Koide, Kazunori, Tracey, Matthew P, Bu, Xiaodong et al.2016 · 31 citationsNature communications. 2016;7:10691
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