WG
William M. Gelbart
cond-mat.softModels, BiologicalNucleic Acid ConformationVirus Assemblycond-mat.stat-mechGenome, ViralModels, ChemicalModels, Molecularq-bio.BMphysics.bio-ph
On Valency
published · living versionsW_xfgrv59f·v1 · currentpublished
Viral self-assembly as a thermodynamic process
with Robijn F. Bruinsma, David Reguera, Joseph Rudnick, Roya Zandi
1 version
Preprints & journals
91 papers in the corpus · 1984–2026In vitro wrapping of nonenveloped viral capsids with lipid bilayers.42817171 · Duran-Meza, Ana Luisa, Villagrana-Escareño, María Verónica, Cadena-Nava, Rubén Darío et al.2026 · 0 citationsBiophysical journal. 2026
The phase-shifting architecture of chromosomes.42594219 · Gelbart, William2026 · 0 citationsScience (New York, N.Y.). 2026;393(6812):664-665
In Trans RNA Replication of a Defective Self-amplifying RNA Lowers RNA Replication But Enhances Protein Translation.42580396 · Moreno Gutierrez, David Silverio, Duran Meza, Ana Luisa, Gelbart, William M2026 · 0 citationsJournal of molecular biology. 2026;438(21):169988
Structural Polymorphs of Self-Assembled Brome Mosaic Virus Capsid Protein.41999668 · Harpell, N, Duran-Meza, A L, Elmer, H et al.2026 · 1 citationThe journal of physical chemistry. B. 2026;130(17):4577-4584
Packaging of Single-Stranded RNA in Viruses and Virus-Like Particles.41950530 · Garmann, Rees F, Gelbart, William M2026 · 3 citationsAnnual review of biochemistry. 2026;95(1):291-315
How much genetic information in RNA form can be protected by a CCMV virus-like particle?41370351 · Duran Meza, Ana Luisa, Porak, Sophie-Christine, Chapman, Abigail et al.2025 · 1 citationPloS one. 2025;20(12):e0336376
Connecting In Vitro and In Vivo Studies of Biomolecular Interaction and Assembly.41061953 · Gelbart, William M, Lomonossoff, George P2025 · 0 citationsJournal of molecular biology. 2025;437(22):169479
A New Approach to In Vivo Transformation of Killer T Cells.40754153 · Rodriguez, Noe, Hofmann, Christian, Yang, Otto O et al.2025 · 3 citationsJournal of molecular biology. 2025;437(22):169369
In Vivo Delivery of Spherical and Cylindrical In Vitro Reconstituted Virus-like Particles Containing the Same Self-Amplifying mRNA.38709860 · Karan, Sweta, Durán-Meza, Ana Luisa, Chapman, Abigail et al.2024 · 16 citationsMolecular pharmaceutics. 2024;21(6):2727-2739
Spontaneous bilayer wrapping of virus particles by a phospholipid Langmuir monolayer.38051443 · Torres-Salgado, J F, Villagrana-Escareño, M V, Duran-Meza, A L et al.2023 · 0 citationsThe European physical journal. E, Soft matter. 2023;46(12):118
Long ssRNA undergoes continuous compaction in the presence of polyvalent cations.37501368 · Duran-Meza, Ana Luisa, Oster, Liya, Sportsman, Richard et al.2023 · 2 citationsBiophysical journal. 2023;122(17):3469-3475
Multiple Nucleocapsid Structural Forms of Shrimp White Spot Syndrome Virus Suggests a Novel Viral Morphogenetic Pathway.37108688 · Huang, Hui-Ju, Tang, Sen-Lin, Chang, Yuan-Chih et al.2023 · 13 citationsInternational journal of molecular sciences. 2023;24(8)
Single-particle studies of the effects of RNA-protein interactions on the self-assembly of RNA virus particles.36122222 · Garmann, Rees F, Goldfain, Aaron M, Tanimoto, Cheylene R et al.2022 · 29 citationsProceedings of the National Academy of Sciences of the United States of America. 2022;119(39):e2206292119
The Nonmonotonic Dose Dependence of Protein Expression in Cells Transfected with Self-Amplifying RNA.35293773 · Tanimoto, Cheylene R, Thurm, Abby R, Brandt, Devin S et al.2022 · 5 citationsJournal of virology. 2022;96(7):e0185821
Controlling the surface charge of simple viruses.34506491 · Duran-Meza, A L, Villagrana-Escareño, M V, Ruiz-García, J et al.2021 · 33 citationsPloS one. 2021;16(9):e0255820
Genome organization and interaction with capsid protein in a multipartite RNA virus.32358197 · Beren, Christian, Cui, Yanxiang, Chakravarty, Antara et al.2020 · 40 citationsProceedings of the National Academy of Sciences of the United States of America. 2020;117(20):10673-10680
RNA Homopolymers Form Higher-Curvature Virus-like Particles Than Do Normal-Composition RNAs.31514968 · Thurm, Abby R, Beren, Christian, Duran-Meza, Ana Luisa et al.2020 · 8 citationsBiophysical journal. 2019;117(7):1331-1341
Delivery of self-amplifying RNA vaccines in in vitro reconstituted virus-like particles.31163034 · Biddlecome, Adam, Habte, Habtom H, McGrath, Katherine M et al.2020 · 67 citationsPloS one. 2019;14(6):e0215031
The effect of macromolecular crowding on single-round transcription by Escherichia coli RNA polymerase.30590739 · Chung, SangYoon, Lerner, Eitan, Jin, Yan et al.2019 · 43 citationsNucleic acids research. 2019;47(3):1440-1450
Correction for Cadena-Nava et al., "Self-Assembly of Viral Capsid Protein and RNA Molecules of Different Sizes: Requirement for a Specific High Protein/RNA Mass Ratio".30723138 · Cadena-Nava, Ruben D, Comas-Garcia, Mauricio, Garmann, Rees F et al.2019 · 3 citationsJournal of virology. 2019;93(4)
Enzymatic Synthesis and Fractionation of Fluorescent PolyU RNAs.34395788 · Beren, Christian, Liu, Katherine N, Dreesens, Lisa L et al.2022 · 0 citationsBio-protocol. 2018;8(17):e2988
Protocol for Efficient Cell-Free Synthesis of Cowpea Chlorotic Mottle Virus-Like Particles Containing Heterologous RNAs.29869247 · Garmann, Rees F, Knobler, Charles M, Gelbart, William M2019 · 5 citationsMethods in molecular biology (Clifton, N.J.). 2018;1776:249-265
The Effect of RNA Secondary Structure on the Self-Assembly of Viral Capsids.28711172 · Beren, Christian, Dreesens, Lisa L, Liu, Katherine N et al.2017 · 38 citationsBiophysical journal. 2017;113(2):339-347
Sizes of Long RNA Molecules Are Determined by the Branching Patterns of Their Secondary Structures.27851933 · Borodavka, Alexander, Singaram, Surendra W, Stockley, Peter G et al.2017 · 60 citationsBiophysical journal. 2016;111(10):2077-2085
Physical Principles in the Self-Assembly of a Simple Spherical Virus.26653769 · Garmann, Rees F, Comas-Garcia, Mauricio, Knobler, Charles M et al.2016 · 121 citationsAccounts of chemical research. 2016;49(1):48-55
Role of RNA Branchedness in the Competition for Viral Capsid Proteins.26435053 · Singaram, Surendra W, Garmann, Rees F, Knobler, Charles M et al.2016 · 27 citationsThe journal of physical chemistry. B. 2015;119(44):13991-4002
Bacteriophage P22 ejects all of its internal proteins before its genome.26245366 · Jin, Yan, Sdao, Sophia M, Dover, John A et al.2016 · 39 citationsVirology. 2015;485:128-34
Controlling the extent of viral genome release by a combination of osmotic stress and polyvalent cations.26382433 · Jin, Yan, Knobler, Charles M, Gelbart, William M2016 · 4 citationsPhysical review. E, Statistical, nonlinear, and soft matter physics. 2015;92(2):022708
DNA-peptide complexes: Regulation of interferon production.26099713 · Gelbart, William M2016 · 6 citationsNature materials. 2015;14(7):661-2
A Simple RNA-DNA Scaffold Templates the Assembly of Monofunctional Virus-Like Particles.26043403 · Garmann, Rees F, Sportsman, Richard, Beren, Christian et al.2016 · 37 citationsJournal of the American Chemical Society. 2015;137(24):7584-7
Visualizing the global secondary structure of a viral RNA genome with cryo-electron microscopy.25752599 · Garmann, Rees F, Gopal, Ajaykumar, Athavale, Shreyas S et al.2015 · 50 citationsRNA (New York, N.Y.). 2015;21(5):877-86
Viral ssRNAs are indeed compact.25564845 · Ben-Shaul, A, Gelbart, W M2015 · 21 citationsBiophysical journal. 2015;108(1):14-6
Viral RNAs are unusually compact.25188030 · Gopal, Ajaykumar, Egecioglu, Defne E, Yoffe, Aron M et al.2015 · 47 citationsPloS one. 2014;9(9):e105875
Characterization of Viral Capsid Protein Self-Assembly around Short Single-Stranded RNA.24933579 · Comas-Garcia, Mauricio, Garmann, Rees F, Singaram, Surendra W et al.2019 · 52 citationsThe journal of physical chemistry. B. 2014;118(27):7510-7519
Role of electrostatics in the assembly pathway of a single-stranded RNA virus.24965458 · Garmann, Rees F, Comas-Garcia, Mauricio, Koay, Melissa S T et al.2015 · 95 citationsJournal of virology. 2014;88(18):10472-9
Electrophoretic mobilities of a viral capsid, its capsid protein, and their relation to viral assembly.24467401 · Vega-Acosta, J R, Cadena-Nava, R D, Gelbart, W M et al.2014 · 41 citationsThe journal of physical chemistry. B. 2014;118(8):1984-9
The assembly pathway of an icosahedral single-stranded RNA virus depends on the strength of inter-subunit attractions.24148696 · Garmann, Rees F, Comas-Garcia, Mauricio, Gopal, Ajaykumar et al.2014 · 108 citationsJournal of molecular biology. 2014;426(5):1050-60
Reconstituted plant viral capsids can release genes to mammalian cells.23608360 · Azizgolshani, Odisse, Garmann, Rees F, Cadena-Nava, Ruben et al.2013 · 95 citationsVirology. 2013;441(1):12-7
In vitro quantification of the relative packaging efficiencies of single-stranded RNA molecules by viral capsid protein.22951822 · Comas-Garcia, Mauricio, Cadena-Nava, Ruben D, Rao, A L N et al.2013 · 80 citationsJournal of virology. 2012;86(22):12271-82
Self-assembly of viral capsid protein and RNA molecules of different sizes: requirement for a specific high protein/RNA mass ratio.22205731 · Cadena-Nava, Ruben D, Comas-Garcia, Mauricio, Garmann, Rees F et al.2012 · 193 citationsJournal of virology. 2012;86(6):3318-26
Visualizing large RNA molecules in solution.22190747 · Gopal, Ajaykumar, Zhou, Z Hong, Knobler, Charles M et al.2012 · 115 citationsRNA (New York, N.Y.). 2012;18(2):284-99
The size of RNA as an ideal branched polymer.22029339 · Fang, Li Tai, Gelbart, William M, Ben-Shaul, Avinoam2012 · 39 citationsThe Journal of chemical physics. 2011;135(15):155105
Rescue of infectious particles from preassembled alphavirus nucleocapsid cores.21471237 · Snyder, Jonathan E, Azizgolshani, Odisse, Wu, Bingbing et al.2011 · 28 citationsJournal of virology. 2011;85(12):5773-81
A sequential folding model predicts length-independent secondary structure properties of long ssRNA.21370842 · Fang, Li Tai, Yoffe, Aron M, Gelbart, William M et al.2011 · 12 citationsThe journal of physical chemistry. B. 2011;115(12):3193-9
Exploiting fluorescent polymers to probe the self-assembly of virus-like particles.21338131 · Cadena-Nava, Ruben D, Hu, Yufang, Garmann, Rees F et al.2011 · 75 citationsThe journal of physical chemistry. B. 2011;115(10):2386-91
Salt-dependent DNA-DNA spacings in intact bacteriophage λ reflect relative importance of DNA self-repulsion and bending energies.21405253 · Qiu, Xiangyun, Rau, Donald C, Parsegian, V Adrian et al.2011 · 74 citationsPhysical review letters. 2011;106(2):028102
The ends of a large RNA molecule are necessarily close.20810537 · Yoffe, Aron M, Prinsen, Peter, Gelbart, William M et al.2011 · 57 citationsNucleic acids research. 2011;39(1):292-9
Multishell structures of virus coat proteins.20369869 · Prinsen, Peter, van der Schoot, Paul, Gelbart, William M et al.2010 · 38 citationsThe journal of physical chemistry. B. 2010;114(16):5522-33
Virology. Pressurized viruses.19325104 · Gelbart, William M, Knobler, Charles M2009 · 93 citationsScience (New York, N.Y.). 2009;323(5922):1682-3
The force acting on a polymer partially confined in a tube.19296704 · Prinsen, Peter, Fang, Li Tai, Yoffe, Aron M et al.2009 · 13 citationsThe journal of physical chemistry. B. 2009;113(12):3873-9
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