SK
Stephan Knecht
hyperpolarizationphysics.chem-phparahydrogenMagnetic Resonance ImagingPyruvic AcidSABREMRIHydrogenHyperpolarizationmetabolic imaging
On Valency
published · living versionsW_4phd5q2e·v1 · currentpublished
Robust nuclear hyperpolarization of small molecules through intermolecular transfer of parahydrogen-derived polarization
with Bogdan A. Rodin, Anna Parker, Laurynas Dagys, Vitaly Kozinenko +10
1 version
Preprints & journals
36 papers in the corpus · 2014–2026Aqueous-Phase Delivery of SLIC-SABRE Hyperpolarized [15N3]Metronidazole.42915672 · Trofimov, Ivan A, de Maissin, Henri, Mohiuddin, Obaid et al.2026 · 0 citationsAnalytical chemistry. 2026;98(39):28656-28665
Robust nuclear hyperpolarization of small molecules through intermolecular transfer of parahydrogen-derived polarization2607.11723v1 · Bogdan A. Rodin, Anna Parker, Laurynas Dagys et al.2026 · 0 citationsarXivon Valency
Improved SABRE hyperpolarisation using pulse sequences to reduce effective coupling.42132853 · Kozinenko, Vitaly P, Rodin, Bogdan A, Eills, James et al.2026 · 1 citationPhysical chemistry chemical physics : PCCP. 2026;28(21):13111-13117
Temperature dependent chemical shifts of pyruvate and lactate enable in vivo hyperpolarized 13C MRSI thermometry.40604117 · Gottwald, Wolfgang, Nagel, Luca, Skinner, Jason G et al.2025 · 1 citationNpj imaging. 2025;3(1):19
In vivo molecular imaging of breast cancer metabolic heterogeneity using [1-13C]pyruvate-d3 hyperpolarized by reversible exchange with parahydrogen.40213665 · Petersen, Stefan, Nagel, Luca, Groß, Philipp R et al.2025 · 18 citationsTheranostics. 2025;15(9):3714-3723
Hyperpolarizing Small Molecules using Parahydrogen and Solid-State Spin Diffusion.38805673 · Gierse, Martin, Dagys, Laurynas, Keim, Michael et al.2024 · 6 citationsAngewandte Chemie (International ed. in English). 2024;63(34):e202319341
Robust parahydrogen-induced polarization at high concentrations.39047103 · Dagys, Laurynas, Korzeczek, Martin C, Parker, Anna J et al.2024 · 24 citationsScience advances. 2024;10(30):eado0373
Towards a unified picture of polarization transfer - pulsed DNP and chemically equivalent PHIP.38614057 · Korzeczek, Martin C, Dagys, Laurynas, Müller, Christoph et al.2024 · 10 citationsJournal of magnetic resonance (San Diego, Calif. : 1997). 2024;362:107671
New Horizons in Hyperpolarized 13C MRI.38147265 · Chaumeil, Myriam M, Bankson, James A, Brindle, Kevin M et al.2024 · 28 citationsMolecular imaging and biology. 2024;26(2):222-232
Hyperpolarizing Small Molecules using Parahydrogen-Induced Polarization and Solid-State Spin Diffusion10.26434/chemrxiv-2023-dhw2t · Martin Gierse, Laurynas Dagys, Michael Keim et al.2023 · 0 citationsChemRxiv
Solution-State 2D NMR Spectroscopy of Mixtures HyperpolarizedUsing Optically Polarized Crystals.37837321 · Parker, Anna J, Dey, Arnab, Usman Qureshi, Mohammad et al.2023 · 8 citationsAngewandte Chemie (International ed. in English). 2023;62(50):e202312302
Parahydrogen-Polarized [1-13 C]Pyruvate for Reliable and Fast Preclinical Metabolic Magnetic Resonance Imaging.37587776 · Nagel, Luca, Gierse, Martin, Gottwald, Wolfgang et al.2023 · 49 citationsAdvanced science (Weinheim, Baden-Wurttemberg, Germany). 2023;10(30):e2303441
In Vivo Metabolic Imaging of [1-13 C]Pyruvate-d3 Hyperpolarized By Reversible Exchange With Parahydrogen.37439488 · de Maissin, Henri, Groß, Philipp R, Mohiuddin, Obaid et al.2023 · 102 citationsAngewandte Chemie (International ed. in English). 2023;62(36):e202306654
Over 20% Carbon-13 Polarization of Perdeuterated Pyruvate Using Reversible Exchange with Parahydrogen and Spin-Lock Induced Crossing at 50 μT.37267594 · Schmidt, Andreas B, Eills, James, Dagys, Laurynas et al.2023 · 50 citationsThe journal of physical chemistry letters. 2023;14(23):5305-5309
Parahydrogen-Polarized Fumarate for Preclinical in Vivo Metabolic Magnetic Resonance Imaging.36857421 · Gierse, Martin, Nagel, Luca, Keim, Michael et al.2023 · 32 citationsJournal of the American Chemical Society. 2023;145(10):5960-5969
Radio-Frequency Sweeps at Microtesla Fields for Parahydrogen-Induced Polarization of Biomolecules.36802642 · Marshall, Alastair, Salhov, Alon, Gierse, Martin et al.2023 · 23 citationsThe journal of physical chemistry letters. 2023;14(8):2125-2132
A disintegrin derivative as a case study for PHIP labeling of disulfide bridged biomolecules.35149768 · Fleckenstein, Max, Herr, Kevin, Theiß, Franziska et al.2022 · 10 citationsScientific reports. 2022;12(1):2337
Hyperpolarized Solution-State NMR Spectroscopy with Optically Polarized Crystals.35113568 · Eichhorn, Tim R, Parker, Anna J, Josten, Felix et al.2022 · 72 citationsJournal of the American Chemical Society. 2022;144(6):2511-2519
Selective excitation of hydrogen doubles the yield and improves the robustness of parahydrogen-induced polarization of low-γ nuclei.34846056 · Schmidt, Andreas B, Brahms, Arne, Ellermann, Frowin et al.2021 · 23 citationsPhysical chemistry chemical physics : PCCP. 2021;23(47):26645-26652
Singlet to triplet conversion in molecular hydrogen and its role in parahydrogen induced polarization.34542122 · Markelov, Danil A, Kozinenko, Vitaly P, Knecht, Stephan et al.2021 · 41 citationsPhysical chemistry chemical physics : PCCP. 2021;23(37):20936-20944
Rapid hyperpolarization and purification of the metabolite fumarate in aqueous solution.33753510 · Knecht, Stephan, Blanchard, John W, Barskiy, Danila et al.2021 · 101 citationsProceedings of the National Academy of Sciences of the United States of America. 2021;118(13)
Singlet-Contrast Magnetic Resonance Imaging: Unlocking Hyperpolarization with Metabolism*.33340439 · Eills, J, Cavallari, E, Kircher, R et al.2021 · 44 citationsAngewandte Chemie (International ed. in English). 2021;60(12):6791-6798
Spin dynamics in experiments on orthodeuterium induced polarization (ODIP).32962366 · Kozinenko, Vitaly P, Kiryutin, Alexey S, Knecht, Stephan et al.2020 · 9 citationsThe Journal of chemical physics. 2020;153(11):114202
Theoretical Description of Hyperpolarization Formation in the SABRE-relay Method2007.13301v1 · Stephan Knecht, Danila A. Barskiy, Gerd Buntkowsky et al.2020 · 17 citationsarXiv
The application of novel Ir-NHC polarization transfer complexes by SABRE.31893872 · Hadjiali, Sara, Bergmann, Marvin, Kiryutin, Alexey et al.2020 · 7 citationsThe Journal of chemical physics. 2019;151(24):244201
Lifetime of Parahydrogen in Aqueous Solutions and Human Blood.31479580 · Schmidt, Andreas B, Wörner, Jakob, Pravdivtsev, Andrey et al.2019 · 11 citationsChemphyschem : a European journal of chemical physics and physical chemistry. 2019;20(19):2408-2412
SABRE: Chemical kinetics and spin dynamics of the formation of hyperpolarization.31779885 · Barskiy, Danila A, Knecht, Stephan, Yurkovskaya, Alexandra V et al.2020 · 179 citationsProgress in nuclear magnetic resonance spectroscopy. 2019;114-115:33-70
Indirect Detection of Short-lived Hydride Intermediates of Iridium N-Heterocyclic Carbene Complexes via Chemical Exchange Saturation Transfer (CEST) Spectroscopy10.26434/chemrxiv.8026049.v1 · Stephan Knecht, Sara Hadjiali, Danila Barskiy et al.2019 · 1 citationChemRxiv
Quantitative quantum mechanical approach to SABRE hyperpolarization at high magnetic fields.30927897 · Knecht, Stephan, Ivanov, Konstantin L2019 · 18 citationsThe Journal of chemical physics. 2019;150(12):124106
Ultrafast Single-Scan 2D NMR Spectroscopic Detection of a PHIP-Hyperpolarized Protease Inhibitor.30698310 · Kiryutin, Alexey S, Sauer, Grit, Tietze, Daniel et al.2019 · 42 citationsChemistry (Weinheim an der Bergstrasse, Germany). 2019;25(16):4025-4030
Efficient conversion of anti-phase spin order of protons into 15N magnetization using SLIC-SABRE1802.04471v1 · Stephan Knecht, Alexey S. Kiryutin, Alexandra V. Yurkovskaya et al.2018 · 0 citationsarXiv
Mechanism of spontaneous polarization transfer in high-field SABRE experiments.29304387 · Knecht, Stephan, Kiryutin, Alexey S, Yurkovskaya, Alexandra V et al.2019 · 34 citationsJournal of magnetic resonance (San Diego, Calif. : 1997). 2018;287:74-81
Re-polarization of nuclear spins using selective SABRE-INEPT.29274936 · Knecht, Stephan, Kiryutin, Alexey S, Yurkovskaya, Alexandra V et al.2019 · 43 citationsJournal of magnetic resonance (San Diego, Calif. : 1997). 2018;287:10-14
Liquid-state carbon-13 hyperpolarization generated in an MRI system for fast imaging.28262691 · Schmidt, A B, Berner, S, Schimpf, W et al.2018 · 74 citationsNature communications. 2017;8:14535
Molecular MRI in the Earth's Magnetic Field Using Continuous Hyperpolarization of a Biomolecule in Water.27228166 · Rovedo, Philipp, Knecht, Stephan, Bäumlisberger, Tim et al.2018 · 39 citationsThe journal of physical chemistry. B. 2016;120(25):5670-7
Continuous re-hyperpolarization of nuclear spins using parahydrogen: theory and experiment.25079961 · Hövener, Jan-Bernd, Knecht, Stephan, Schwaderlapp, Niels et al.2015 · 50 citationsChemphyschem : a European journal of chemical physics and physical chemistry. 2014;15(12):2451-7
Career total: at least 70 works. 36 are in this corpus.
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