KD
Karl Deisseroth
neuroscienceoptogeneticsOptogeneticsRewardLightNeuronsSocial BehaviorBrainBehavior, Animalreward
On Valency
published · living versionsW_qwe58ep4·v1 · currentpublished
The Open Connectome Project Data Cluster: Scalable Analysis and Vision for High-Throughput Neuroscience
with Randal Burns, William Gray Roncal, Dean Kleissas, Kunal Lillaney +15
1 version
Preprints & journals
542 papers in the corpus · 1990–2026Neocortical long-range inhibition promotes cortical synchrony and sleep.42717094 · Ratliff, Jacob M, Terral, Geoffrey, Vazquez, Arenski et al.2026 · 0 citationsNature. 2026
Developmental xenocortication using human-derived organoids in mice.42749812 · Kaganovsky, Konstantin, Kelley, Kevin W, Gschwind, Tilo et al.2026 · 2 citationsNature. 2026
POCO: Scalable Neural Forecasting through Population Conditioning.42111903 · Duan, Yu, Chaudhry, Hamza Tahir, Ahrens, Misha B et al.2026 · 0 citationsAdvances in neural information processing systems. 2025;38:23631-23669
Applications of synthetic polymers directed toward living cells.41103682 · Zhang, Anqi, Zhao, Spencer, Tyson, Jonathan et al.2026 · 46 citationsNature synthesis. 2024;3(8):943-957
Rapid stereo-EEG network mapping enables personalized multinodal stimulation for refractory facial pain.42532258 · Huang, Yuhao, McGeoch, Paul D, Kaboodvand, Neda et al.2026 · 0 citationsBrain stimulation. 2026;19(5):103176
AAV delivered lysosome-targeting chimeras mediate sustained antibody depletion in vivo.42465314 · Yang, Jonathan Lee, Loh, Kang Yong, Sandoval Espinoza, Cindy Rosaura et al.2026 · 0 citationsbioRxiv : the preprint server for biology. 2026
Inferring brain-wide interactions using data-constrained recurrent neural network models.42567158 · Perich, Matthew G, Arlt, Charlotte, Soares, Sofia et al.2026 · 68 citationsNeuron. 2026
Genetically targeted photocatalytic organic dyes for spatiotemporally controlled organic synthesis in specific living cells.42420503 · Zhao, Spencer, Loh, Kang Yong, Tyson, Jonathan et al.2026 · 2 citationsNature chemistry. 2026;18(9):1553-1563
Author Correction: Maturation and circuit integration of transplanted human cortical organoids.42547828 · Revah, Omer, Gore, Felicity, Kelley, Kevin W et al.2026 · 0 citationsNature. 2026;656(8128):E41
Distinct properties of glutamate-dopamine, nonglutamate-dopamine, and glutamate-only ventral tegmental area neurons.42611973 · Prévost, Emily D, Ward, Lucy A, Alas, Daniel et al.2026 · 0 citationsScience signaling. 2026;19(951):eaee2028
Raster photostimulation of large-scale neural populations10.64898/2026.04.21.719951v2 · LaFosse, P. K., Flickinger, D., Jaindl, G. et al.2026 · 1 citationbioRxiv
Optimized genetic tracers for viral mediated neuronal projection mapping.41794669 · Dulin, Jennifer N, Ye, Li, Grider, Teresa et al.2026 · 1 citationCellular & molecular biology letters. 2026;31(1)
Ultrasensitive voltage imaging reveals distinct electrical microdomains in neurons10.64898/2026.05.27.728040v1 · Hao, Y. A., Jayne, L. L., Lee, S. et al.2026 · 0 citationsbioRxiv
Intrinsic space-time couplings governing multi-scale cortical dynamics10.64898/2026.05.27.726038v1 · White, A. D., Wang, Y., Kochalka, J. et al.2026 · 0 citationsbioRxiv
Causal and directional elements of global brain dynamics10.64898/2026.05.27.726039v2 · Kochalka, J., Mitra, A., White, A. D. et al.2026 · 0 citationsbioRxiv
Aging-related vulnerability in dopamine-glutamate neurons weakens entorhinal dopamine signaling and underlies novelty discrimination deficits.42078876 · Tomaio, Jacquelyn N, Li, Yifei, Ghazy, Omar et al.2026 · 0 citationsResearch square. 2026
POCO: Scalable Neural Forecasting through Population Conditioning.40980761 · Duan, Yu, Chaudhry, Hamza Tahir, Ahrens, Misha B et al.2026 · 0 citationsArXiv. 2025
Functional remodeling of the parasubthalamic nucleus drives alcohol drinking escalation in dependence10.64898/2026.04.30.722112v1 · Dunning, J. L., Kreifeldt, M., Okhuarobo, A. et al.2026 · 0 citationsbioRxiv
Experience-Dependent Plasticity of Thalamoprefrontal Circuitry Characterizes Learning Across Species10.1101/2025.11.23.689976v3 · Elkinbard, I., Sadeghzadeh, S., Hedlund, M. et al.2025 · 0 citationsbioRxiv
Lifelong behavioral screen reveals an architecture of vertebrate aging.41818367 · Bedbrook, Claire N, Nath, Ravi D, Zhang, Libby et al.2026 · 14 citationsScience (New York, N.Y.). 2026;391(6790):eaea9795
Selective Vulnerability of Dopamine-Glutamate Neurons in Aging Weakens Entorhinal Dopamine Signaling10.1101/2025.10.06.680552v2 · Tomaio, J. N., Fleury, S., Bilder, A. et al.2025 · 1 citationbioRxiv
Mimicking opioid analgesia in cortical pain circuits.41501467 · Oswell, Corinna S, Rogers, Sophie A, James, Justin G et al.2026 · 7 citationsNature. 2026;649(8098):938-947
Neocortical long-range inhibition promotes cortical synchrony and sleep10.1101/2024.06.20.599756v2 · Ratliff, J. M., Terral, G., Vazquez Lechuga, A. et al.2024 · 12 citationsbioRxiv
Serotonergic neuron-glioma interactions drive high-grade glioma pathophysiology10.64898/2025.12.10.693579v1 · Drexler, R., Yalcin, B., Mancusi, R. et al.2025 · 5 citationsbioRxiv
Roadmap for direct and indirect translation of optogenetics into discoveries and therapies for humans.41254285 · Lüscher, Christian, Emiliani, Valentina, Farahany, Nita et al.2025 · 11 citationsNature neuroscience. 2025;28(12):2415-2431
Life-long behavioral screen reveals an architecture of vertebrate aging10.1101/2025.11.21.688112v1 · Bedbrook, C. N., Nath, R. D., Zhang, L. et al.2025 · 1 citationbioRxiv
Ribosome-Associated Vesicles promote activity-dependent local translation in neurons10.1101/2024.06.07.598007v3 · Martin-Solana, E., Carter, S. D., Krishnamurthy, K. et al.2024 · 8 citationsbioRxiv
Quantitative profiling of whole-brain connectomes at single-axon resolution using deep learning and high-resolution light sheet microscopy10.1101/2025.11.14.688340v1 · Attarpour, A., Raffiee, M., Xu, T. et al.2025 · 1 citationbioRxiv
A software platform for real-time and adaptive neuroscience experiments.41219202 · Draelos, Anne, Loring, Matthew D, Nikitchenko, Maxim et al.2025 · 4 citationsNature communications. 2025;16(1):9909
POCO: Scalable Neural Forecasting through Population Conditioning2506.14957v2 · Yu Duan, Hamza Tahir Chaudhry, Misha B. Ahrens et al.2025 · 0 citationsarXiv
Environmental Novelty Modulates Rapid Cortical Plasticity During Navigation10.1101/2025.10.21.683723v1 · Attinger, A., Drinnenberg, A., Dong, C. et al.2025 · 3 citationsbioRxiv
Large-scale cellular-resolution read/write of activity enables discovery of cell types defined by complex circuit properties10.1101/2025.10.21.683734v1 · Drinnenberg, A., Attinger, A., Raventos, A. et al.2025 · 2 citationsbioRxiv
Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies.33953663 · Vedam-Mai, Vinata, Deisseroth, Karl, Giordano, James et al.2025 · 76 citationsFrontiers in human neuroscience. 2021;15:644593
Cholinergic neuronal activity promotes diffuse midline glioma growth through muscarinic signaling.40541184 · Drexler, Richard, Drinnenberg, Antonia, Gavish, Avishai et al.2025 · 56 citationsCell. 2025;188(17):4640-4657.e30
Corrigendum: Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies.34658825 · Vedam-Mai, Vinata, Deisseroth, Karl, Giordano, James et al.2025 · 5 citationsFrontiers in human neuroscience. 2021;15:765150
Neurobiology of Thirst and Hunger Drives.40198847 · Encarnacion-Rivera, Lucas, Deisseroth, Karl, Luo, Liqun2025 · 14 citationsAnnual review of neuroscience. 2025;48(1):381-403
Sexually dimorphic mechanisms of VGLUT-mediated protection from dopaminergic neurodegeneration10.1101/2023.10.02.560584v2 · Buck, S. A., Rubin, S. A., Kunkhyen, T. et al.2023 · 8 citationsbioRxiv
Salience Signaling and Stimulus Scaling of Ventral Tegmental Area Glutamate Neuron Subtypes.40473473 · McGovern, Dillon J, Phillips, Alysabeth, Ly, Annie et al.2025 · 5 citationsThe Journal of neuroscience : the official journal of the Society for Neuroscience. 2025;45(27)
Enhancer AAVs for targeting spinal motor neurons and descending motor pathways in rodents and macaque.39131318 · Kussick, Emily, Johansen, Nelson, Taskin, Naz et al.2025 · 5 citationsbioRxiv : the preprint server for biology. 2025
Enhancer AAVs for targeting spinal motor neurons and descending motor pathways in rodents and macaque.40403722 · Kussick, Emily, Johansen, Nelson, Taskin, Naz et al.2025 · 23 citationsCell reports. 2025;44(6):115730
Conserved brain-wide emergence of emotional response from sensory experience in humans and mice.40440375 · Kauvar, Isaac, Richman, Ethan B, Liu, Tony X et al.2025 · 26 citationsScience (New York, N.Y.). 2025;388(6750):eadt3971
Food and water intake are regulated by distinct central amygdala circuits revealed using intersectional genetics.40157920 · Fermani, Federica, Chang, Simon, Mastrodicasa, Ylenia et al.2025 · 15 citationsNature communications. 2025;16(1):3072
A deep learning pipeline for three-dimensional brain-wide mapping of local neuronal ensembles in teravoxel light-sheet microscopy.39870865 · Attarpour, Ahmadreza, Osmann, Jonas, Rinaldi, Anthony et al.2025 · 20 citationsNature methods. 2025;22(3):600-611
Negative Affect Circuit Subtypes and Neural, Behavioral, and Affective Responses to MDMA: A Randomized Clinical Trial.40305021 · Zhang, Xue, Hack, Laura M, Bertrand, Claire et al.2025 · 12 citationsJAMA network open. 2025;8(4):e257803
A brain-wide map of descending inputs onto spinal V1 interneurons.39719703 · Chapman, Phillip D, Kulkarni, Anand S, Trevisan, Alexandra J et al.2025 · 15 citationsNeuron. 2025;113(4):524-538.e6
Mimicking opioid analgesia in cortical pain circuits10.1101/2024.04.26.591113v2 · Oswell, C. S., Rogers, S. A., James, J. G. et al.2024 · 20 citationsbioRxiv
Activity of a direct VTA to ventral pallidum GABA pathway encodes unconditioned reward value and sustains motivation for reward.36260661 · Zhou, Wen-Liang, Kim, Kristen, Ali, Farhan et al.2025 · 54 citationsScience advances. 2022;8(42):eabm5217
Mapping the cellular etiology of schizophrenia and complex brain phenotypes.39833308 · Duncan, Laramie E, Li, Tayden, Salem, Madeleine et al.2025 · 62 citationsNature neuroscience. 2025;28(2):248-258
Convergent state-control of endogenous opioid analgesia10.1101/2025.01.03.631111v1 · Kimmey, B. A., Ejoh, L., Shangloo, L. et al.2025 · 6 citationsbioRxiv
The parasubthalamic nucleus refeeding ensemble delays feeding initiation and hastens water drinking.38965421 · Dunning, Jeffery L, Lopez, Catherine, Krull, Colton et al.2024 · 15 citationsMolecular psychiatry. 2025;30(1):37-49
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