RB
Raphael Bigler
asymmetric catalysiscross-coupling1,1-diarylalkanealcoholsaromaticsarylationAtroposelective Negishi couplingboronic esterboronic estersCatalysis
On Valency
published · living versionsW_qjnbn88u·v1 · currentpublished
Dynamic language model representations for multi-objective reaction optimisation
with Joshua W. Sin, David Ming Segura, Bojana Ranković, Siu Lun Chau +6
1 version
Preprints & journals
14 papers in the corpus · 2014–2026Dynamic language model representations for multi-objective reaction optimisation2609.11790v1 · Joshua W. Sin, David Ming Segura, Bojana Rankovi'c et al.2026 · 0 citationsarXivon Valency
A Highly Atroposelective Negishi Coupling Enables the Commercial Manufacturing Process of Divarasib.42633623 · Bachmann, Stephan, Bigler, Raphael, Kaldre, Danis et al.2026 · 0 citationsChimia. 2026;80(7-8):450-457
Single-position ligand modifications tune CB2R activity by targeting the toggle switch.41859514 · Ganzoni, Rudolf L Z, Kosar, Miroslav, Han, Yongqi et al.2026 · 2 citationsChemical science. 2026;17(18):8976-8988
Swarm Intelligence for Chemical Reaction Optimisation2509.11798v1 · R'emi Schlama, Joshua W. Sin, Ryan P. Burwood et al.2025 · 0 citationsarXiv
Highly parallel optimisation of chemical reactions through automation and machine intelligence.40651950 · Sin, Joshua W, Chau, Siu Lun, Burwood, Ryan P et al.2025 · 32 citationsNature communications. 2025;16(1):6464
A machine-learning tool to predict substrate-adaptive conditions for Pd-catalyzed C-N couplings.37651532 · Rinehart, N Ian, Saunthwal, Rakesh K, Wellauer, Joël et al.2023 · 141 citationsScience (New York, N.Y.). 2023;381(6661):965-972
Second-Generation Atroposelective Synthesis of KRAS G12C Covalent Inhibitor GDC-6036.37162129 · Xu, Jie, Lim, Ngiap-Kie, Timmerman, Jacob C et al.2023 · 27 citationsOrganic letters. 2023;25(19):3417-3422
Development and Validation of a Chemoinformatic Workflow for Predicting Reaction Yield for Pd-Catalyzed C-N Couplings with Substrate Generalizability10.26434/chemrxiv-2022-hspwv-v2 · N. Ian Rinehart, Rakesh K. Saunthwal, Joël Wellauer et al.2022 · 1 citationChemRxiv
Asymmetric Hydrogenation of Unfunctionalized Tetrasubstituted Acyclic Olefins.31794118 · Bigler, Raphael, Mack, Kyle A, Shen, Jeff et al.2020 · 50 citationsAngewandte Chemie (International ed. in English). 2020;59(7):2844-2849
Enantiospecific Synthesis of ortho-Substituted 1,1-Diarylalkanes by a 1,2-Metalate Rearrangement/anti-SN 2' Elimination/Rearomatizing Allylic Suzuki-Miyaura Reaction Sequence.30520228 · Rubial, Belén, Collins, Beatrice S L, Bigler, Raphael et al.2020 · 21 citationsAngewandte Chemie (International ed. in English). 2019;58(5):1366-1370
ortho-Directing Chromium Arene Complexes as Efficient Mediators for Enantiospecific C(sp2 )-C(sp3 ) Cross-Coupling Reactions.29227017 · Bigler, Raphael, Aggarwal, Varinder K2019 · 26 citationsAngewandte Chemie (International ed. in English). 2018;57(4):1082-1086
Enantiospecific Synthesis of ortho-Substituted Benzylic Boronic Esters by a 1,2-Metalate Rearrangement/1,3-Borotropic Shift Sequence.28661133 · Aichhorn, Stefan, Bigler, Raphael, Myers, Eddie L et al.2018 · 54 citationsJournal of the American Chemical Society. 2017;139(28):9519-9522
Highly enantioselective transfer hydrogenation of ketones with chiral (NH)2 P2 macrocyclic iron(II) complexes.25845557 · Bigler, Raphael, Huber, Raffael, Mezzetti, Antonio2015 · 160 citationsAngewandte Chemie (International ed. in English). 2015;54(17):5171-4
Isonitrile iron(II) complexes with chiral N2P2 macrocycles in the enantioselective transfer hydrogenation of ketones.25493619 · Bigler, Raphael, Mezzetti, Antonio2015 · 74 citationsOrganic letters. 2014;16(24):6460-3
Career total: 66 works. 14 are in this corpus.
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