LC

Le Cong

0000-0003-4725-8714

cs.AIbioinformaticscs.LGCRISPR-Cas SystemsGene EditingClustered Regularly Interspaced Short Palindromic Repeatsq-bio.BMcs.CRq-bio.QMCOVID-19

On Valency

published · living versions

LabWorld: Learning Interactive 4D Worlds for Scientific Experimentation

with Suozhi Huang, Kelsey Fu, Binxu Li, Luna Lyu +10

1 version

W_yupgfwy4v1 · current

Preprints & journals

80 papers in the corpus · 2008–2026

Autonomous biomedical research with an artificial intelligence agent.

Huang, Kexin, Zhang, Serena, Wang, Hanchen et al.

37 citations

424244362026Science (New York, N.Y.). 2026;393(6813):eadz4351

Active-GRPO: Adaptive Imitation and Self-Improving Reasoning for Molecular Optimization

Xuefeng Liu, Mingxuan Cao, Qinan Huang et al.

0 citations

2607.00531v12026arXiv

Optimizing microhomology-based genome editing by engineering DNA polymerase θ for improved efficiency and reduced on-target indels.

Wang, Wanyi, Zhou, Meng, Ji, Tianshan et al.

0 citations

422355122026Cell reports methods. 2026;6(8):101474

Science Earth: Towards A Planet-Scale Operating System for AI-Native Scientific Discovery

Zhe Zhao, Haibin Wen, Yingcheng Wu et al.

0 citations

2606.01316v22026arXiv

BiomniBench: Process-level Evaluation of LLM Agents for Real-world Biomedical Research

Qu, Y., Lu, Y., Tu, X. et al.

1 citation

10.64898/2026.05.12.724604v22026bioRxiv

SWE-Milestone: Evaluating AI Agents on Continuous Software Evolution

Gangda Deng, Zhaoling Chen, Zhongming Yu et al.

0 citations

2603.13428v42026arXiv

Minimizing far-extending chromatin perturbation in genome editing preserves stem cell identity.

Zhu, Ming, Yuan, Junsong, Meng, Qiuchen et al.

3 citations

417424192026Cell stem cell. 2026;33(3):470-486.e14

LatentChem: From Textual CoT to Latent Thinking in Chemical Reasoning

Xinwu Ye, Yicheng Mao, Yuxuan Liao et al.

0 citations

2602.07075v62026arXiv

Publisher Correction: CRISPR-GPT for agentic automation of gene-editing experiments.

Qu, Yuanhao, Huang, Kaixuan, Yin, Ming et al.

2 citations

413616002026Nature biomedical engineering. 2026;10(2):405

Molecular Representations in Implicit Functional Space via Hyper-Networks

Zehong Wang, Xiaolong Han, Qi Yang et al.

0 citations

2601.22327v12026arXiv

Compact bacterial recombination complexes drive efficient kilobase-scale knock-in in mammalian cells.

Luo, Yining, Jiang, Qin, Qu, Yuanhao et al.

2 citations

415691632026Nucleic acids research. 2026;54(2)

Evaluating Large Language Models in Scientific Discovery

Zhangde Song, Jieyu Lu, Yuanqi Du et al.

3 citations

2512.15567v22025arXiv

Autonomous AI Agents Discover Aging Interventions from Millions of Molecular Profiles.

Ying, Kejun, Tyshkovskiy, Alexander, Moldakozhayev, Alibek et al.

22 citations

413326612025bioRxiv : the preprint server for biology. 2025

LabOS: The AI-XR Co-Scientist That Sees and Works With Humans

Le Cong, David Smerkous, Xiaotong Wang et al.

6 citations

2510.14861v22025arXiv

Generative AI for Biosciences: Emerging Threats and Roadmap to Biosecurity

Zaixi Zhang, Souradip Chakraborty, Amrit Singh Bedi et al.

1 citation

2510.15975v22025arXiv

Securing the Language of Life: Inheritable Watermarks from DNA Language Models to Proteins

Zaixi Zhang, Ruofan Jin, Le Cong et al.

0 citations

2509.18207v12025arXiv

Surfaceome CRISPR activation screening uncovers ligands regulating tumor sensitivity to NK cell killing.

Dinesh, Ravi K, Wang, Xiaotong, Mohammad, Imran A et al.

2 citations

410009862026bioRxiv : the preprint server for biology. 2025

BioLab: End-to-End Autonomous Life Sciences Research with Multi-Agents System Integrating Biological Foundation Models

Jin, R., Guo, Y., Qu, Y. et al.

3 citations

10.1101/2025.09.03.674085v12025bioRxiv

SafeProtein: Red-Teaming Framework and Benchmark for Protein Foundation Models

Jigang Fan, Zhenghong Zhou, Ruofan Jin et al.

0 citations

2509.03487v22025arXiv

CRISPR-GPT for Agentic Automation of Gene Editing Experiments.

Qu, Yuanhao, Huang, Kaixuan, Yin, Ming et al.

146 citations

394639612025bioRxiv : the preprint server for biology. 2025

Membrane-wide screening identifies potential tissue-specific determinants of SARS-CoV-2 tropism.

Dinesh, Ravi K, Wang, Chengkun, Qu, Yuanhao et al.

3 citations

406744062025PLoS pathogens. 2025;21(7):e1013157

STELLA: Self-Evolving LLM Agent for Biomedical Research

Ruofan Jin, Zaixi Zhang, Mengdi Wang et al.

7 citations

2507.02004v12025arXiv

Genome-Bench: A Scientific Reasoning Benchmark from Real-World Expert Discussions

Yin, M., Qu, Y., Liu, D. et al.

1 citation

10.1101/2025.06.02.657538v12025bioRxiv

FoldMark: Safeguarding Protein Structure Generative Models with Distributional and Evolutionary Watermarking

ZHANG, Z., Jin, R., Liu, J. et al.

7 citations

10.1101/2024.10.23.619960v82024bioRxiv

Biomni: A General-Purpose Biomedical AI Agent.

Huang, Kexin, Zhang, Serena, Wang, Hanchen et al.

124 citations

405019242026bioRxiv : the preprint server for biology. 2025

GeneBreaker: Jailbreak Attacks against DNA Language Models with Pathogenicity Guidance

Zaixi Zhang, Zhenghong Zhou, Ruofan Jin et al.

3 citations

2505.23839v12025arXiv

Toward Scientific Reasoning in LLMs: Training from Expert Discussions via Reinforcement Learning

Ming Yin, Yuanhao Qu, Ling Yang et al.

0 citations

2505.19501v22025arXiv

A call for built-in biosecurity safeguards for generative AI tools.

Wang, Mengdi, Zhang, Zaixi, Bedi, Amrit Singh et al.

28 citations

402957842026Nature biotechnology. 2025;43(6):845-847

Gene Editing for ATXN3 Inactivation in Machado-Joseph disease: CRISPR-Cas9 as a Therapeutic Alternative to TALEN-Induced Toxicity

Lopes, S. M., Lopes, M. M., Oliveira, D. et al.

0 citations

10.1101/2025.02.14.637261v12025bioRxiv

RNAGenesis: A Generalist Foundation Model for Functional RNA Therapeutics

Zhang, Z., Jin, R., Chao, L. et al.

17 citations

10.1101/2024.12.30.630826v32024bioRxiv

FoldMark: Protecting Protein Generative Models with Watermarking

Zaixi Zhang, Ruofan Jin, Kaidi Fu et al.

0 citations

2410.20354v42024arXiv

Computationally guided high-throughput engineering of an anti-CRISPR protein for precise genome editing in human cells.

Marsiglia, Julia, Vaalavirta, Kia, Knight, Estefany et al.

7 citations

394377142024Cell reports methods. 2024;4(10):100882

Latent Diffusion Models for Controllable RNA Sequence Generation

Kaixuan Huang, Yukang Yang, Kaidi Fu et al.

1 citation

2409.09828v22024arXiv

Efficient and multiplexed somatic genome editing with Cas12a mice.

Hebert, Jess D, Xu, Haiqing, Tang, Yuning J et al.

18 citations

384964632026bioRxiv : the preprint server for biology. 2024

A 5' UTR Language Model for Decoding Untranslated Regions of mRNA and Function Predictions.

Chu, Yanyi, Yu, Dan, Li, Yupeng et al.

143 citations

388552632026Nature machine intelligence. 2024;6(4):449-460

Protein language model-guided engineering of an anti-CRISPR protein for precise genome editing in human cells

Marsiglia, J., Vaalavirta, K., Knight, E. et al.

1 citation

10.1101/2023.12.13.571376v12023bioRxiv

APOE loss-of-function variants: Compatible with longevity and associated with resistance to Alzheimer's Disease pathology.

Chemparathy, Augustine, Guen, Yann Le, Chen, Sunny et al.

45 citations

375470162026medRxiv : the preprint server for health sciences. 2023

Long sequence insertion via CRISPR/Cas gene-editing with transposase, recombinase, and integrase.

Wang, Xiaotong, Xu, Guangxue, Johnson, William A et al.

14 citations

385496862024Current opinion in biomedical engineering. 2023;28

Integrative analysis of functional genomic screening and clinical data identifies a protective role for spironolactone in severe COVID-19.

Cousins, Henry C, Kline, Adrienne Sarah, Wang, Chengkun et al.

5 citations

375293682023Cell reports methods. 2023;3(7):100503

Gene set proximity analysis: expanding gene set enrichment analysis through learned geometric embeddings, with drug-repurposing applications in COVID-19.

Cousins, Henry, Hall, Taryn, Guo, Yinglong et al.

9 citations

363942542023Bioinformatics (Oxford, England). 2023;39(1)

Single-cell transcriptome analysis of regenerating RGCs reveals potent glaucoma neural repair genes.

Li, Liang, Fang, Fang, Feng, Xue et al.

71 citations

359526722022Neuron. 2022;110(16):2646-2663.e6

Integrative analysis of viral entry networks and clinical outcomes identifies a protective role for spironolactone in severe COVID-19

Cousins, H., Kline, A. S., Wang, C. et al.

0 citations

10.1101/2022.07.02.22277181v12022medRxiv

Machine-learning-optimized Cas12a barcoding enables the recovery of single-cell lineages and transcriptional profiles.

Hughes, Nicholas W, Qu, Yuanhao, Zhang, Jiaqi et al.

30 citations

357521722022Molecular cell. 2022;82(16):3103-3118.e8

Editorial: CRISPR and alternative approaches.

Kapusi, Eszter, Cong, Le, Stoger, Eva

0 citations

357266632022Biotechnology journal. 2022;17(7):e2200290

CRISPR-Cas12a System With Synergistic Phage Recombination Proteins for Multiplex Precision Editing in Human Cells.

Wang, Chengkun, Xia, Qiong, Zhang, Qianhe et al.

11 citations

357741042026Frontiers in cell and developmental biology. 2021;9:719705

Bandit Theory and Thompson Sampling-Guided Directed Evolution for Sequence Optimization

Hui Yuan, Chengzhuo Ni, Huazheng Wang et al.

5 citations

2206.02092v12022arXiv

dCas9-based gene editing for cleavage-free genomic knock-in of long sequences.

Wang, Chengkun, Qu, Yuanhao, Cheng, Jason K W et al.

81 citations

351452212022Nature cell biology. 2022;24(2):268-278

Conventional type I dendritic cells maintain a reservoir of proliferative tumor-antigen specific TCF-1+ CD8+ T cells in tumor-draining lymph nodes.

Schenkel, Jason M, Herbst, Rebecca H, Canner, David et al.

286 citations

345344392021Immunity. 2021;54(10):2338-2353.e6

Deciphering pathogenicity of variants of uncertain significance with CRISPR-edited iPSCs.

Guo, Hongchao, Liu, Lichao, Nishiga, Masataka et al.

24 citations

345092992022Trends in genetics : TIG. 2021;37(12):1109-1123

CRISPRa screening with real world evidence identifies potassium channels as neuronal entry factors and druggable targets for SARS-CoV-2

Wang, C., Dinesh, R., Qu, Y. et al.

7 citations

10.1101/2021.07.01.450475v22021bioRxiv

Career total: 124 works. 80 are in this corpus.Showing the 50 most recent.

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