VM
Vincent Michel
COVID-19microbiologySARS-CoV-2deafnessGene therapyGenetic Therapyhair cellhearingNeuroscienceSensory neuroscience
On Valency
published · living versionsW_dwtmxhph·v1 · currentpublished
Scikit-learn: Machine Learning in Python
with Fabian Pedregosa, Gaël Varoquaux, Alexandre Gramfort, Bertrand Thirion +14
1 version
Preprints & journals
51 papers in the corpus · 1998–2026Temperature-dependent replication and sensitivity to innate immunity of human coronavirus HKU1.42649161 · Buchrieser, Julian, Thuillier, Eva, Postal, Jeanne et al.2026 · 0 citationsNature communications. 2026;17(1)
Dual AAV gene therapy achieves recovery of hearing and auditory processing in a DFNB16 mouse model.41508981 · Iranfar, Sepideh, Bagur, Sophie, Felgerolle, Chloé et al.2026 · 2 citationsClinical and translational medicine. 2026;16(1):e70571
Stealth replication of SARS-CoV-2 Omicron in the nasal epithelium at physiological temperature.41416837 · Fonseca, Bárbara F, Robinot, Rémy, Michel, Vincent et al.2026 · 3 citationsJournal of virology. 2026;100(1):e0200825
Targeting ACE2 with a camelid antibody inhibits SARS-CoV-2 binding and has protective effects in vivo.41271706 · Blachier, Simon, Vaney, Marie-Christine, Conquet, Laurine et al.2025 · 1 citationNature communications. 2025;16(1):10268
Super-resolution mapping of the ankle link proteins ADGRV1 and PDZD7 in developing auditory hair cells.40836926 · Colcombet-Cazenave, Baptiste, Moneron, Gaël, El Helou, Antonio et al.2025 · 1 citationiScience. 2025;28(8):113190
The SARS-CoV-2 envelope PDZ binding motif acts as a virulence factor disrupting host's epithelial cell-cell junctions.40646464 · Alvarez, Flavio, de Melo, Guilherme Dias, Larrous, Florence et al.2025 · 8 citationsCellular & molecular biology letters. 2025;30(1):80
Modeling viral and bacterial infections in human lung organotypic systems reveals strain specific host responses10.1101/2025.03.31.644992v3 · Faria Fonseca, B., Wong-Ng, J., Connor, M. et al.2025 · 2 citationsbioRxiv
Intranasal delivery of a broadly neutralizing single domain antibody targeting ACE2 protects against SARS-CoV-2 infection10.1101/2024.10.11.617877v1 · Blachier, S., Fernandez, I., Conquet, L. et al.2024 · 0 citationsbioRxiv
Distinct evolution of SARS-CoV-2 Omicron XBB and BA.2.86/JN.1 lineages combining increased fitness and antibody evasion.38045308 · Planas, Delphine, Staropoli, Isabelle, Michel, Vincent et al.2026 · 266 citationsbioRxiv : the preprint server for biology. 2024
Extended time frame for restoring inner ear function through gene therapy in Usher1G preclinical model.38194286 · Lahlou, Ghizlene, Calvet, Charlotte, Simon, François et al.2024 · 13 citationsJCI insight. 2024;9(3)
High fusion and cytopathy of SARS-CoV-2 variant B.1.640.1.38088562 · Bolland, William, Michel, Vincent, Planas, Delphine et al.2024 · 7 citationsJournal of virology. 2024;98(1):e0135123
TMPRSS2 is a functional receptor for human coronavirus HKU1.37879362 · Saunders, Nell, Fernandez, Ignacio, Planchais, Cyril et al.2023 · 110 citationsNature. 2023;624(7990):207-214
The SNARE protein SNAP-25 is required for normal exocytosis at auditory hair cell ribbon synapses.36483015 · Calvet, Charlotte, Peineau, Thibault, Benamer, Najate et al.2022 · 30 citationsiScience. 2022;25(12):105628
Olfactory outcomes in Zika virus-associated Guillain-Barré syndrome.35699338 · Lazarini, Françoise, Lannuzel, Annie, Cabié, André et al.2022 · 7 citationsEuropean journal of neurology. 2022;29(9):2823-2831
Implication of Vestibular Hair Cell Loss of Planar Polarity for the Canal and Otolith-Dependent Vestibulo-Ocular Reflexes in Celsr1-/- Mice.34790090 · Simon, François, Tissir, Fadel, Michel, Vincent et al.2022 · 16 citationsFrontiers in neuroscience. 2021;15:750596
SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance.34272374 · Robinot, Rémy, Hubert, Mathieu, de Melo, Guilherme Dias et al.2021 · 272 citationsNature communications. 2021;12(1):4354
COVID-19-related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters.33941622 · de Melo, Guilherme Dias, Lazarini, Françoise, Levallois, Sylvain et al.2021 · 502 citationsScience translational medicine. 2021;13(596)
[The sea anemone Nematostella vectensis, an emerging model for biomedical research: Mechano-sensitivity, extreme regeneration and longevity].33591260 · Amiel, Aldine R, Michel, Vincent, Carvalho, João E et al.2021 · 7 citationsMedecine sciences : M/S. 2021;37(2):167-177
Ultrarare heterozygous pathogenic variants of genes causing dominant forms of early-onset deafness underlie severe presbycusis.33229591 · Boucher, Sophie, Tai, Fabienne Wong Jun, Delmaghani, Sedigheh et al.2021 · 57 citationsProceedings of the National Academy of Sciences of the United States of America. 2020;117(49):31278-31289
SARS-CoV-2 infection damages airway motile cilia and impairs mucociliary clearance10.1101/2020.10.06.328369v1 · Robinot, R., Hubert, M., Dias de Melo, G. et al.2020 · 26 citationsbioRxiv
Interaction of protocadherin-15 with the scaffold protein whirlin supports its anchoring of hair-bundle lateral links in cochlear hair cells.33009420 · Michel, Vincent, Pepermans, Elise, Boutet de Monvel, Jacques et al.2020 · 14 citationsScientific reports. 2020;10(1):16430
Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.31776257 · Avan, Paul, Le Gal, Sébastien, Michel, Vincent et al.2020 · 70 citationsProceedings of the National Academy of Sciences of the United States of America. 2019;116(51):25948-25957
Stiffness and tension gradients of the hair cell's tip-link complex in the mammalian cochlea.30932811 · Tobin, Mélanie, Chaiyasitdhi, Atitheb, Michel, Vincent et al.2020 · 75 citationseLife. 2019;8
Clarin-1 gene transfer rescues auditory synaptopathy in model of Usher syndrome.29985171 · Dulon, Didier, Papal, Samantha, Patni, Pranav et al.2019 · 141 citationsThe Journal of clinical investigation. 2018;128(8):3382-3401
CIB2, defective in isolated deafness, is key for auditory hair cell mechanotransduction and survival.29084757 · Michel, Vincent, Booth, Kevin T, Patni, Pranav et al.2018 · 83 citationsEMBO molecular medicine. 2017;9(12):1711-1731
Local gene therapy durably restores vestibular function in a mouse model of Usher syndrome type 1G.28835534 · Emptoz, Alice, Michel, Vincent, Lelli, Andrea et al.2018 · 138 citationsProceedings of the National Academy of Sciences of the United States of America. 2017;114(36):9695-9700
Auditory cortex interneuron development requires cadherins operating hair-cell mechanoelectrical transduction.28705869 · Libé-Philippot, Baptiste, Michel, Vincent, Boutet de Monvel, Jacques et al.2018 · 51 citationsProceedings of the National Academy of Sciences of the United States of America. 2017;114(30):7765-7774
Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.27534441 · Potter, Paul K, Bowl, Michael R, Jeyarajan, Prashanthini et al.2018 · 100 citationsNature communications. 2016;7:12444
Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth.26754646 · Lelli, Andrea, Michel, Vincent, Boutet de Monvel, Jacques et al.2016 · 67 citationsThe Journal of cell biology. 2016;212(2):231-44
The CD2 isoform of protocadherin-15 is an essential component of the tip-link complex in mature auditory hair cells.24940003 · Pepermans, Elise, Michel, Vincent, Goodyear, Richard et al.2015 · 80 citationsEMBO molecular medicine. 2014;6(7):984-92
An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells.24920589 · Kamiya, Kazusaku, Michel, Vincent, Giraudet, Fabrice et al.2014 · 22 citationsProceedings of the National Academy of Sciences of the United States of America. 2014;111(25):9307-12
Localization of Usher 1 proteins to the photoreceptor calyceal processes, which are absent from mice.23045546 · Sahly, Iman, Dufour, Eric, Schietroma, Cataldo et al.2013 · 191 citationsThe Journal of cell biology. 2012;199(2):381-99
Coupling of the mechanotransduction machinery and F-actin polymerization in the cochlear hair bundles.22069509 · Caberlotto, Elisa, Michel, Vincent, de Monvel, Jacques Boutet et al.2021 · 32 citationsBioarchitecture. 2011;1(4):169-174
Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia.21436032 · Caberlotto, Elisa, Michel, Vincent, Foucher, Isabelle et al.2011 · 158 citationsProceedings of the National Academy of Sciences of the United States of America. 2011;108(14):5825-30
Cadherin-23, myosin VIIa and harmonin, encoded by Usher syndrome type I genes, form a ternary complex and interact with membrane phospholipids.20639393 · Bahloul, Amel, Michel, Vincent, Hardelin, Jean-Pierre et al.2010 · 108 citationsHuman molecular genetics. 2010;19(18):3557-65
Cochlear outer hair cells undergo an apical circumference remodeling constrained by the hair bundle shape.20332152 · Etournay, Raphaël, Lepelletier, Léa, Boutet de Monvel, Jacques et al.2010 · 65 citationsDevelopment (Cambridge, England). 2010;137(8):1373-83
Harmonin-b, an actin-binding scaffold protein, is involved in the adaptation of mechanoelectrical transduction by sensory hair cells.19756723 · Michalski, Nicolas, Michel, Vincent, Caberlotto, Elisa et al.2010 · 89 citationsPflugers Archiv : European journal of physiology. 2009;459(1):115-30
Vezatin, an integral membrane protein of adherens junctions, is required for the sound resilience of cochlear hair cells.20049712 · Bahloul, Amel, Simmler, Marie-Christine, Michel, Vincent et al.2010 · 43 citationsEMBO molecular medicine. 2009;1(2):125-38
Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness.19043416 · Lagresle-Peyrou, Chantal, Six, Emmanuelle M, Picard, Capucine et al.2009 · 238 citationsNature genetics. 2009;41(1):106-11
A core cochlear phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation and differential growth.18339676 · Lefèvre, Gaelle, Michel, Vincent, Weil, Dominique et al.2008 · 214 citationsDevelopment (Cambridge, England). 2008;135(8):1427-37
Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning.17567809 · Michalski, Nicolas, Michel, Vincent, Bahloul, Amel et al.2007 · 218 citationsThe Journal of neuroscience : the official journal of the Society for Neuroscience. 2007;27(24):6478-88
Mutations in the gene encoding pejvakin, a newly identified protein of the afferent auditory pathway, cause DFNB59 auditory neuropathy.16804542 · Delmaghani, Sedigheh, del Castillo, Francisco J, Michel, Vincent et al.2006 · 336 citationsNature genetics. 2006;38(7):770-8
Usherin, the defective protein in Usher syndrome type IIA, is likely to be a component of interstereocilia ankle links in the inner ear sensory cells.16301217 · Adato, Avital, Lefèvre, Gaëlle, Delprat, Benjamin et al.2006 · 184 citationsHuman molecular genetics. 2005;14(24):3921-32
Cadherin 23 is a component of the transient lateral links in the developing hair bundles of cochlear sensory cells.15882573 · Michel, Vincent, Goodyear, Richard J, Weil, Dominique et al.2005 · 166 citationsDevelopmental biology. 2005;280(2):281-94
Myosin XVa and whirlin, two deafness gene products required for hair bundle growth, are located at the stereocilia tips and interact directly.15590698 · Delprat, Benjamin, Michel, Vincent, Goodyear, Richard et al.2005 · 190 citationsHuman molecular genetics. 2005;14(3):401-10
Interactions in the network of Usher syndrome type 1 proteins.15590703 · Adato, Avital, Michel, Vincent, Kikkawa, Yoshiaki et al.2005 · 244 citationsHuman molecular genetics. 2005;14(3):347-56
Molecular mechanism of a frequent genetic form of deafness.12917317 · Michel, Vincent, Hardelin, Jean-Pierre, Petit, Christine2003 · 19 citationsThe New England journal of medicine. 2003;349(7):716-7
Targeted ablation of connexin26 in the inner ear epithelial gap junction network causes hearing impairment and cell death.12121617 · Cohen-Salmon, Martine, Ott, Thomas, Michel, Vincent et al.2003 · 445 citationsCurrent biology : CB. 2002;12(13):1106-11
Functional alterations in the olfactory bulb of the staggerer mutant mouse.10696797 · Michel, V, Monnier, Z, Guastavino, J M et al.2000 · 6 citationsNeuroscience letters. 2000;280(1):1-4
Organotypic culture of neuroepithelium attached to olfactory bulb from adult mouse as a tool to study neuronal regeneration after ZnSO4 neuroepithelial trauma.10507702 · Michel, V, Monnier, Z, Cvetkovic, V et al.1999 · 9 citationsNeuroscience letters. 1999;271(3):195-8
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