DU
Derya Unutmaz
immunologyLymphocyte ActivationFatigue Syndrome, ChronicGene Expression RegulationMucosal-Associated Invariant T CellsbioprintingBioprintingBreast Neoplasmscancerchildren
On Valency
published · living versionsW_qrshuaqb·v1 · currentpublished
Early science acceleration experiments with GPT-5
with Sébastien Bubeck, Christian Coester, Ronen Eldan, Timothy Gowers +9
1 version
Preprints & journals
161 papers in the corpus · 1993–2026Roads and detours for CAR T cell therapy in autoimmune diseases.41588112 · Avouac, Jérôme, Barzel, Adi, Caiati, Delma et al.2026 · 22 citationsNature reviews. Drug discovery. 2026;25(4):290-309
Longevity Bench: Are SotA LLMs ready for aging research?10.64898/2026.01.12.698650v3 · Zhavoronkov, A., Sidorenko, D., Naumov, V. et al.2026 · 0 citationsbioRxiv
Early science acceleration experiments with GPT-52511.16072v1 · S'ebastien Bubeck, Christian Coester, Ronen Eldan et al.2025 · 3 citationsarXivon Valency
Single-cell map of the healthy human immune system across the lifespan reveals unique infant immune signatures.40766403 · Nehar-Belaid, Djamel, Thibodeau, Asa, Eroglu, Alper et al.2026 · 7 citationsbioRxiv : the preprint server for biology. 2025
AI-driven multi-omics modeling of myalgic encephalomyelitis/chronic fatigue syndrome.40715814 · Xiong, Ruoyun, Aiken, Elizabeth, Caldwell, Ryan et al.2025 · 21 citationsNature medicine. 2025;31(9):2991-3001
Novel Flavonoid Derivatives Show Potent Efficacy in Human Lymphoma Models.40538494 · Gaudio, Eugenio, Biniecka, Paulina, Arribas, Alberto J et al.2025 · 0 citationsEJHaem. 2025;6(3):e70081
Epidermal Growth Factor Receptor Regulates Beclin-1 in Hyperoxic Acute Lung Injury.40475627 · Harris, Zachary M, Korde, Asawari, Khoury, Johad et al.2026 · 2 citationsbioRxiv : the preprint server for biology. 2025
BioMapAI: Artificial Intelligence Multi-Omics Modeling of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome.38979186 · Xiong, Ruoyun, Aiken, Elizabeth, Caldwell, Ryan et al.2026 · 5 citationsbioRxiv : the preprint server for biology. 2025
Fast Targeted Metabolomics for Analyzing Metabolic Diversity of Bacterial Indole Derivatives in ME/CFS Gut Microbiome.39131327 · Tian, Huidi, Wang, Lei, Aiken, Elizabeth et al.2024 · 1 citationbioRxiv : the preprint server for biology. 2024
Engineering programmable CAR-T cells with tunable controls as fail-safe mechanisms during cancer immunotherapy10.1101/2024.07.09.602762v1 · Dogan, M., Kozhaya, L., Placek, L. et al.2024 · 0 citationsbioRxiv
Mucosal-associated invariant T cells in cancer: dual roles, complex interactions and therapeutic potential.38545100 · Yigit, Mesut, Basoglu, Omer Faruk, Unutmaz, Derya2024 · 35 citationsFrontiers in immunology. 2024;15:1369236
Bioassay-Driven, Fractionation-Empowered, Focused Metabolomics for Discovering Bacterial Activators of Aryl Hydrocarbon Receptor.38308645 · Tian, Huidi, Wang, Lei, Hardy, Rachel et al.2024 · 5 citationsJournal of the American Society for Mass Spectrometry. 2024;35(3):518-526
STAT4 Phosphorylation of T-helper Cells predicts surgical outcomes in Refractory Chronic Rhinosinusitis.38168423 · Abidin, Michael R, Alpan, Oral, Plassmeyer, Matthew et al.2024 · 1 citationmedRxiv : the preprint server for health sciences. 2023
Cognitive impairment in post-acute sequelae of COVID-19 and short duration myalgic encephalomyelitis patients is mediated by orthostatic hemodynamic changes.37434760 · Day, Heather, Yellman, Brayden, Hammer, Sarah et al.2024 · 7 citationsFrontiers in neuroscience. 2023;17:1203514
GARP on hepatic stellate cells is essential for the development of liver fibrosis.37348791 · Zhang, Xiaolong, Sharma, Pankaj, Maschmeyer, Patrick et al.2024 · 38 citationsJournal of hepatology. 2023;79(5):1214-1225
A genome-wide CRISPR activation screen identifies SCREEM a novel SNAI1 super-enhancer demarcated by eRNAs.36923642 · Uthaya Kumar, Dinesh Babu, Yurieva, Marina, Grassmann, Jessica et al.2024 · 4 citationsFrontiers in molecular biosciences. 2023;10:1110445
Multi-'omics of gut microbiome-host interactions in short- and long-term myalgic encephalomyelitis/chronic fatigue syndrome patients.36758521 · Xiong, Ruoyun, Gunter, Courtney, Fleming, Elizabeth et al.2023 · 118 citationsCell host & microbe. 2023;31(2):273-287.e5
Improvement of Long COVID symptoms over one year.36698810 · Oliveira, Carlos R, Jason, Leonard A, Unutmaz, Derya et al.2024 · 42 citationsFrontiers in medicine. 2022;9:1065620
Post-exertional malaise among people with long COVID compared to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).36911963 · Vernon, Suzanne D, Hartle, Megan, Sullivan, Karen et al.2023 · 76 citationsWork (Reading, Mass.). 2023;74(4):1179-1186
Targeting SARS-CoV-2 infection through CAR-T-like bispecific T cell engagers incorporating ACE2.36285327 · Dogan, Mikail, Kozhaya, Lina, Placek, Lindsey et al.2022 · 16 citationsClinical & translational immunology. 2022;11(10):e1421
Chemotherapeutics and CAR-T Cell-Based Immunotherapeutics Screening on a 3D Bioprinted Vascularized Breast Tumor Model.38938621 · Dey, Madhuri, Kim, Myoung Hwan, Dogan, Mikail et al.2024 · 60 citationsAdvanced functional materials. 2022;32(52)
Biofabrication of 3D breast cancer models for dissecting the cytotoxic response of human T cells expressing engineered MAIT cell receptors.36108605 · Dey, Madhuri, Kim, Myong Hwan, Nagamine, Momoka et al.2022 · 30 citationsBiofabrication. 2022;14(4)
Epidermal Growth Factor Receptor Inhibition Is Protective in Hyperoxia-Induced Lung Injury.36193076 · Harris, Zachary M, Sun, Ying, Joerns, John et al.2022 · 8 citationsOxidative medicine and cellular longevity. 2022;2022:9518592
Engineering Human MAIT Cells with Chimeric Antigen Receptors for Cancer Immunotherapy.36165183 · Dogan, Mikail, Karhan, Ece, Kozhaya, Lina et al.2022 · 73 citationsJournal of immunology (Baltimore, Md. : 1950). 2022;209(8):1523-1531
Engineering human Mucosal Associated Invariant T (MAIT) cells with chimeric antigen receptors for cancer immunotherapy10.1101/2022.07.28.501764v1 · Dogan, M., Karhan, E., Kozhaya, L. et al.2022 · 2 citationsbioRxiv
Antibody Responses to SARS-CoV-2 After Infection or Vaccination in Children and Young Adults With Inflammatory Bowel Disease.34528661 · Dailey, Joelynn, Kozhaya, Lina, Dogan, Mikail et al.2022 · 41 citationsInflammatory bowel diseases. 2022;28(7):1019-1026
CCR5: The Receptor That Unlocks the Door for HIV Entry into Cells.35595303 · Unutmaz, Derya2022 · 2 citationsJournal of immunology (Baltimore, Md. : 1950). 2022;208(11):2459-2460
3D Bioprinted perfusable and vascularized breast tumor model for dynamic screening of chemotherapeutics and CAR-T cells10.1101/2022.03.15.484485v1 · Dey, M., Kim, M. H., Nagamine, M. et al.2022 · 6 citationsbioRxiv
Modulation of glucose metabolism by 2-Deoxy-D-Glucose (2DG) promotes IL-17 producing human T cell subsets10.1101/2022.03.13.484135v2 · Chen, X., Kozhaya, L., Wang, C. et al.2022 · 0 citationsbioRxiv
Development of 3D breast cancer models with human T cells expressing engineered MAIT cell receptors10.1101/2022.01.29.478309v1 · Dey, M., Kim, M. H., Nagamine, M. et al.2022 · 1 citationbioRxiv
Disease Progression in Children With Perinatal Human Immunodeficiency Virus Correlates With Increased PD-1+ CD8 T Cells That Coexpress Multiple Immune Checkpoints.33864071 · Tailor, Janki, Foldi, Julia, Generoso, Matthew et al.2022 · 3 citationsThe Journal of infectious diseases. 2021;224(10):1785-1795
Multi-omics of host-microbiome interactions in short- and long-term Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)10.1101/2021.10.27.466150v1 · xiong, r., Gunter, C., Fleming, E. et al.2021 · 0 citationsbioRxiv
3D Bioprinting for fabrication of tissue models of COVID-19 infection.34028514 · Kabir, Anisha, Datta, Pallab, Oh, Julia et al.2021 · 20 citationsEssays in biochemistry. 2021;65(3):503-518
Network Topology of Biological Aging and Geroscience-Guided Approaches to COVID-19.35128530 · Landay, Alan, Bartley, Jenna, Banerjee, Dishary et al.2024 · 6 citationsFrontiers in aging. 2021;2
Studying Tumor Angiogenesis and Cancer Invasion in a Three-Dimensional Vascularized Breast Cancer Micro-Environment.33857356 · Dey, Madhuri, Ayan, Bugra, Yurieva, Marina et al.2021 · 55 citationsAdvanced biology. 2021;5(7):e2100090
Whole-genome screen identifies diverse pathways that negatively regulate ciliogenesis.33206585 · Failler, Marion, Giro-Perafita, Ariadna, Owa, Mikito et al.2021 · 28 citationsMolecular biology of the cell. 2021;32(2):169-185
Novel SARS-CoV-2 specific antibody and neutralization assays reveal wide range of humoral immune response during COVID-19.32676617 · Dogan, Mikail, Kozhaya, Lina, Placek, Lindsey et al.2022 · 131 citationsmedRxiv : the preprint server for health sciences. 2020
Hemodynamics during the 10-minute NASA Lean Test: evidence of circulatory decompensation in a subset of ME/CFS patients.32799889 · Lee, Jihyun, Vernon, Suzanne D, Jeys, Patricia et al.2021 · 52 citationsJournal of translational medicine. 2020;18(1):314
Mechanisms of T-Cell Exhaustion in Pancreatic Cancer.32823814 · Saka, Didem, Gökalp, Muazzez, Piyade, Betül et al.2020 · 157 citationsCancers. 2020;12(8)
3D bioprinting for reconstituting the cancer microenvironment.32793806 · Datta, Pallab, Dey, Madhuri, Ataie, Zaman et al.2024 · 305 citationsNPJ precision oncology. 2020;4:18
STIM1-mediated calcium influx controls antifungal immunity and the metabolic function of non-pathogenic Th17 cells.32609955 · Kahlfuss, Sascha, Kaufmann, Ulrike, Concepcion, Axel R et al.2021 · 50 citationsEMBO molecular medicine. 2020;12(8):e11592
LDB1 Enforces Stability on Direct and Indirect Oncoprotein Partners in Leukemia.32229578 · Layer, Justin H, Christy, Michael, Placek, Lindsey et al.2020 · 21 citationsMolecular and cellular biology. 2020;40(12)
A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by Treg cells.32499651 · Nasrallah, Rabab, Imianowski, Charlotte J, Bossini-Castillo, Lara et al.2020 · 55 citationsNature. 2020;583(7816):447-452
Structure-based discovery of a small-molecule inhibitor of methicillin-resistant Staphylococcus aureus virulence.32179646 · Liu, Jie, Kozhaya, Lina, Torres, Victor J et al.2020 · 31 citationsThe Journal of biological chemistry. 2020;295(18):5944-5959
Decoy exosomes provide protection against bacterial toxins.32132711 · Keller, Matthew D, Ching, Krystal L, Liang, Feng-Xia et al.2020 · 239 citationsNature. 2020;579(7798):260-264
Perturbation of effector and regulatory T cell subsets in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)10.1101/2019.12.23.887505v1 · Karhan, E., Gunter, C., Ravanmehr, V. et al.2019 · 14 citationsbioRxiv
Immune cells for microbiota surveillance.31649181 · Oh, Julia, Unutmaz, Derya2019 · 12 citationsScience (New York, N.Y.). 2019;366(6464):419-420
Live cell kinetic analysis of the LMO2/LDB1 leukemogenic protein complex reveals a hierarchy of turnover with implications for complex assembly10.1101/706259v2 · Layer, J. H., Christy, M., Placek, L. et al.2019 · 0 citationsbioRxiv
T-Cell-Intrinsic Receptor Interacting Protein 2 Regulates Pathogenic T Helper 17 Cell Differentiation.30366765 · Shimada, Kenichi, Porritt, Rebecca A, Markman, Janet L et al.2019 · 29 citationsImmunity. 2018;49(5):873-885.e7
Low Peripheral T Follicular Helper Cells in Perinatally HIV-Infected Children Correlate With Advancing HIV Disease.30197641 · McCarty, Bret, Mwamzuka, Mussa, Marshed, Fatma et al.2019 · 14 citationsFrontiers in immunology. 2018;9:1901
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