FS
Franziska Seeger
bioinformaticsAntibodies, MonoclonalComplementarity Determining RegionsProtein Engineeringq-bio.BMAffinity maturationantibodyAntibody Affinityantibody engineeringAntigens
On Valency
published · living versionsW_fwzmgj9y·v1 · currentpublished
iGC: Antibody Optimization via Reinforcement Learning over a Learned Somatic Hypermutation Prior
with Thao Nguyen, Robert G. Alberstein, Ewa Nowara, Homa MohammadiPeyhani +8
1 version
Preprints & journals
10 papers in the corpus · 2019–2026MIMOSA: Guiding De Novo Antibody Design with Natural Interaction Fingerprints10.64898/2026.09.24.753155v1 · Abanades, B., Roncoli, A., Bhagawati, M. et al.2026 · 0 citationsbioRxiv
DyAb: sequence-based antibody design and property prediction in a low-data regime.42665538 · Lin, Joshua Yao-Yu, Hofmann, Jennifer L, Leaver-Fay, Andrew et al.2026 · 2 citationsmAbs. 2026;18(1):2717460
Local electrostatics governs tryptophan oxidation and enables rational stability engineering in antibodies.42590841 · Lenka, Sunidhi, Mehta, Shrenik, Stephens, Nicole et al.2026 · 0 citationsmAbs. 2026;18(1):2713231
Disentangling multispecific antibody function with graph neural networks2601.23212v1 · Joshua Southern, Changpeng Lu, Santrupti Nerli et al.2026 · 1 citationarXiv
Conformation-aware structure prediction of antigen-recognizing immune proteins.41378904 · Dreyer, Frédéric A, Ludwiczak, Jan, Martinkus, Karolis et al.2025 · 4 citationsmAbs. 2026;18(1):2602217
CDR Conformation Aware Antibody Sequence Design with ConformAb10.1101/2025.11.12.688095v1 · Sinha, I., Stanton, S., Lillington, S. et al.2025 · 1 citationbioRxiv
Rational design of oxidation-resistant antibodies through local electrostatic modulation10.1101/2025.06.29.662139v1 · Lenka, S., Mehta, S., Stephens, N. et al.2025 · 0 citationsbioRxiv
Rapid affinity optimization of an anti-TREM2 clinical lead antibody by cross-lineage immune repertoire mining.39333507 · Hsiao, Yi-Chun, Wallweber, Heidi Ackerly, Alberstein, Robert G et al.2024 · 8 citationsNature communications. 2024;15(1):8382
Improving Generalizability of Protein Sequence Models with Data Augmentations10.1101/2021.02.18.431877v1 · Shen, H., Price, L. C., Bahadori, M. T. et al.2021 · 15 citationsbioRxiv
Feature Design for Protein Interface hotspots using KFC2 and Rosetta10.1101/514372v1 · Seeger, F., Little, A., Chen, Y. et al.2019 · 1 citationbioRxiv
Career total: 22 works. 10 are in this corpus.
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