KA
Konstantinos Arfanakis
Alzheimer DiseaseAgingCognitionCognitive DysfunctionBrainMRIagingAlzheimer's diseaseWhite MatterMagnetic Resonance Imaging
On Valency
published · living versionsW_hbjrxy96·v1 · currentpublished
Discovering Subtypes of Neurodegenerative Progression with a Scalable Connectome-Constrained Dynamic Model
with Daniel Semchin, Emile d'Angremont, Hao Ding, Alan Antar +4
1 version
Preprints & journals
194 papers in the corpus · 2000–2026Discovering Subtypes of Neurodegenerative Progression with a Scalable Connectome-Constrained Dynamic Model2609.10890v1 · Daniel Semchin, Emile d'Angremont, Hao Ding et al.2026 · 0 citationsarXivon Valency
MARBLE: An in vivo MRI marker of limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC).42745216 · Tazwar, Mahir, Evia, Arnold M, Ridwan, Abdur R et al.2026 · 0 citationsAlzheimer's & dementia : the journal of the Alzheimer's Association. 2026;22(9):e71832
Differential Associations of Microglial Inflammation on LATE-NC and Tangle-Related Hippocampal Atrophy10.64898/2026.08.24.744255v1 · Kapasi, A., Yu, L., Leurgans, S. E. et al.2026 · 0 citationsbioRxiv
Multi-region brain transcriptomes uncover two subtypes of aging individuals with differences in Alzheimer risk and the impact of APOEε4.42620705 · Lee, Annie J, Ma, Yiyi, Yu, Lei et al.2026 · 0 citationsiScience. 2026;29(8):117038
Age at Menopause and Brain Atrophy Among Older Women.42640635 · Campagna, M Pia, Schneider, Julie A, Barnes, Lisa L et al.2026 · 2 citationsJAMA network open. 2026;9(8):e2630973
Brain morphometry patterns in the presence of Alzheimer's disease and/or LATE neuropathologic changes.42576193 · Saifullah, Khalid, Ridwan, Abdur Raquib, Evia, Arnold M et al.2026 · 0 citationsAlzheimer's & dementia : the journal of the Alzheimer's Association. 2026;22(8):e71719
MIND diet, cerebrovascular health, and cognition among community-dwelling older adults.42625492 · Agarwal, Puja, Lamar, Melissa, Kapasi, Alifiya et al.2026 · 0 citationsAlzheimer's & dementia : the journal of the Alzheimer's Association. 2026;22(8):e71772
Adherence to the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet and longitudinal changes in global cognition: a post hoc analysis of the MIND trial.42457038 · Dhana, Klodian, Aggarwal, Neelum T, Ventrelle, Jennifer et al.2026 · 0 citationsThe American journal of clinical nutrition. 2026;124(3):101433
Genetic architecture of the limbic white matter microstructure in aging and Alzheimer's Disease.42410730 · Lorenz, Anna S, Sathe, Aditi, Yang, Yisu et al.2026 · 0 citationsAlzheimer's & dementia : the journal of the Alzheimer's Association. 2026;22(7):e71630
Associations of stable psychological traits with multi-omic subtypes of Alzheimer's dementia.42324246 · Zammit, Andrea R, Yu, Lei, Poole, Victoria N et al.2026 · 1 citationTranslational psychiatry. 2026;16(1)
Diffusion abnormalities associated with brain arteriolosclerosis: An in-vivo MRI and pathology study in community-based older adults.42217311 · Tomash, Ana, Tazwar, Mahir, Yasar, Md Tahmid et al.2026 · 1 citationNeurobiology of aging. 2026;166:82-89
Automated detection of cerebral microbleeds on ex-vivo MRI scans of community-based older adults.42107619 · Nikseresht, Grant, Evia, Arnold M, Agam, Gady et al.2026 · 1 citationNeuroImage. 2026;335:121986
Dietary intervention and cognition across Alzheimer's disease biomarker levels: The MIND clinical trial.42033408 · Dhana, Klodian, Aggarwal, Neelum T, Arfanakis, Konstantinos et al.2026 · 1 citationJournal of Alzheimer's disease : JAD. 2026;111(3):1301-1308
Sub-Networks of the Brain R2 Structural Connectome Integrity Matrix (SCIM) and Older Adult Cognitive and Motor Functioning.41847971 · Lamar, Melissa, Wagner, Maude, Leurgans, Sue E et al.2026 · 0 citationsHuman brain mapping. 2026;47(4):e70510
The Consortium for Clarity in ADRD Research Through Imaging (CLARiTI): Overview of consortium sites and anticipated enrollment.41208739 · Oomens, Julie E, Biber, Sarah A, Albert, Marilyn et al.2025 · 1 citationAlzheimer's & dementia : the journal of the Alzheimer's Association. 2025;21(11):e70880
Nutrition Effects on Brain Outcomes and Recovery in Stroke after Hospitalization (NOURISH): Randomized controlled trial protocol and rationale.41076115 · Cherian, Laurel, Agarwal, Puja, Dhana, Klodian et al.2025 · 1 citationContemporary clinical trials. 2025;158:108108
Molecular and neuropathological determinants of neuronal dysfunction in Alzheimer's disease.41278736 · Sanchez-Rodriguez, Lazaro M, Hong, Joon Hwan, Pak, Veronika et al.2025 · 1 citationbioRxiv : the preprint server for biology. 2025
Effect of weight loss through dietary interventions on cardiometabolic health in older adults.41044190 · Dhana, Klodian, Aggarwal, Neelum T, Voigt, Robin M et al.2025 · 4 citationsInternational journal of obesity (2005). 2025;49(12):2503-2510
Effect modifiers of the MIND diet for cognition in older adults: The MIND diet trial.41058007 · Halloway, Shannon, Aggarwal, Neelum T, Arfanakis, Konstantinos et al.2025 · 6 citationsAlzheimer's & dementia : the journal of the Alzheimer's Association. 2025;21(10):e70731
MarkVCID2 Consortium for Clinical Validation of Biomarkers of Cerebral Small Vessel Disease: Validation Framework and Baseline Characteristics.40977537 · Greenberg, Steven M, Albert, Marylin S, An, Hongyu et al.2026 · 8 citationsAnnals of neurology. 2026;99(2):449-458
Association of an in vivo classifier for ARTerioloSclerosis (ARTS) with cortical thickness and cognition in older adults.40974878 · Kapasi, Alifiya, Wagner, Maude, Evia, Arnold M et al.2025 · 2 citationsNeurobiology of aging. 2025;156:143-149
Advancing clinical trial readiness in white matter disease and related dementias: key steps for future research progress.40690160 · Sompol, Pradoldej, Jicha, Gregory A, Hinman, Jason D et al.2026 · 0 citationsGeroScience. 2026;48(2):2505-2522
Neuropathological Correlates of Volume and Shape of Deep Gray Matter Structures in Community-Based Older Adults.40580018 · Saifullah, Khalid, Makkinejad, Nazanin, Yasar, Md Tahmid et al.2025 · 6 citationsHuman brain mapping. 2025;46(10):e70273
ARTS is associated with vascular risk factors, MCI, dementia, and stroke.40588724 · Fleischman, Debra A, Arfanakis, Konstantinos, Leurgans, Sue E et al.2025 · 6 citationsAlzheimer's & dementia : the journal of the Alzheimer's Association. 2025;21(7):e70430
The future of biomarkers for vascular contributions to cognitive impairment and dementia (VCID): proceedings of the 2025 annual workshop of the Albert research institute for white matter and cognition.40542975 · Lennon, Matthew J, Karvelas, Nikolaos, Ganesh, Aravind et al.2025 · 8 citationsGeroScience. 2025;47(5):6177-6190
White Matter Abnormalities and Cognition in Aging and Alzheimer Disease.40513084 · Peter, Christopher, Sathe, Aditi, Shashikumar, Niranjana et al.2025 · 55 citationsJAMA neurology. 2025;82(8):825-836
Genetic architecture of the limbic white matter microstructure in aging and Alzheimer's Disease.40475163 · Lorenz, Anna, Sathe, Aditi, Yang, Yisu et al.2026 · 0 citationsmedRxiv : the preprint server for health sciences. 2025
Cerebral Amyloid Angiopathy Is Associated With Higher R2 Relaxation Rate: An MRI and Pathology Study.40244903 · Yasar, Md Tahmid, Evia, Arnold M, Tazwar, Mahir et al.2025 · 1 citationAnnals of clinical and translational neurology. 2025;12(6):1214-1224
Assessing Cognitive Decline and Dementia Risk in Black and White Older Adults with Blood Biomarkers pTau217, GFAP, NfL, and Aβ ratio.40297430 · Capuano, Ana W, Bennett, David A, Dage, Jeffrey L et al.2025 · 8 citationsmedRxiv : the preprint server for health sciences. 2025
Associations between APOE-TOMM40 '523 haplotypes and limbic system white matter microstructure.40201595 · Mooney, Katelyn E, Archer, Derek B, Sathe, Aditi et al.2026 · 1 citationAlzheimer's & dementia (Amsterdam, Netherlands). 2025;17(2):e70099
The effect of Alzheimer's disease genetic factors on limbic white matter microstructure.40219815 · Lorenz, Anna, Sathe, Aditi, Zaras, Dimitrios et al.2025 · 8 citationsAlzheimer's & dementia : the journal of the Alzheimer's Association. 2025;21(4):e70130
Translating the Post-Mortem Brain Multi-Omics Molecular Taxonomy of Alzheimer's Dementia to Living Humans.40196602 · Iturria-Medina, Yasser, Poole, Victoria N, Zammit, Andrea R et al.2025 · 1 citationbioRxiv : the preprint server for biology. 2025
Multi-omic subtypes of Alzheimer's dementia are differentially associated with psychological traits.40060468 · Zammit, Andrea R, Yu, Lei, Poole, Victoria N et al.2026 · 2 citationsbioRxiv : the preprint server for biology. 2025
Head Motion in Diffusion Magnetic Resonance Imaging: Quantification, Mitigation, and Structural Associations in Large, Cross-Sectional Datasets Across the Lifespan.39935269 · Schilling, Kurt G, Ramadass, Karthik, Sairanen, Viljami et al.2025 · 1 citationHuman brain mapping. 2025;46(3):e70143
Dynamic proportional loss of functional connectivity revealed change of left superior frontal gyrus in subjective cognitive decline: an explanatory study based on Chinese and Western cohorts.39888585 · Wang, Luyao, Hu, Wenjing, Dong, Fan et al.2025 · 2 citationsGeroScience. 2025;47(4):5619-5634
Clinical criteria for limbic-predominant age-related TDP-43 encephalopathy.39807681 · Wolk, David A, Nelson, Peter T, Apostolova, Liana et al.2025 · 93 citationsAlzheimer's & dementia : the journal of the Alzheimer's Association. 2025;21(1):e14202
Change in transverse relaxation rates (R2) and change in cognition for older African Americans.40454627 · Lamar, Melissa, Arfanakis, Konstantinos, Capuano, Ana W et al.2025 · 2 citationsHuman brain mapping. 2025;46(1):e26794
MRI free water mediates the association between diffusion tensor image analysis along the perivascular space and executive function in four independent middle to aged cohorts.39740225 · Liu, Xiaodan, Maillard, Pauline, Barisano, Giuseppe et al.2025 · 35 citationsAlzheimer's & dementia : the journal of the Alzheimer's Association. 2025;21(2):e14453
Sex and APOE ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer's disease.39711105 · Peterson, Amalia, Sathe, Aditi, Zaras, Dimitrios et al.2025 · 17 citationsAlzheimer's & dementia : the journal of the Alzheimer's Association. 2025;21(1):e14343
Image Processing in the Acute to Chronic Pain Signatures (A2CPS) Project10.1101/2024.12.19.627509v1 · Sadil, P., Arfanakis, K., Bhuiyan, E. H. et al.2024 · 3 citationsbioRxiv
The Consortium for Clarity in ADRD Research Through Imaging (CLARiTI).39588767 · Mormino, Elizabeth C, Biber, Sarah A, Rahman-Filipiak, Annalise et al.2025 · 13 citationsAlzheimer's & dementia : the journal of the Alzheimer's Association. 2025;21(1):e14383
Biological validation of peak-width of skeletonized mean diffusivity as a VCID biomarker: The MarkVCID Consortium.39569745 · Luckey, Alison M, Ghosh, Saptaparni, Wang, Chen-Pin et al.2024 · 13 citationsAlzheimer's & dementia : the journal of the Alzheimer's Association. 2024;20(12):8814-8824
Differential correlations of changes in in vivo neuroimaging markers of hippocampal volume and arteriolosclerosis with declining financial and health literacy in old age.39352643 · Yu, Lei, Wang, Tianhao, Kapasi, Alifiya et al.2024 · 0 citationsBrain imaging and behavior. 2024;18(6):1515-1523
Associations between structural neuroimaging markers of Alzheimer's risk and scam susceptibility.39347939 · Lamar, Melissa, Arfanakis, Konstantinos, Kapasi, Alifiya et al.2024 · 5 citationsBrain imaging and behavior. 2024;18(6):1491-1498
Intracranial atherosclerotic disease and neurodegeneration: a narrative review and plausible mechanisms.39303868 · Yang, Dixon, Cherian, Laurel, Arfanakis, Konstantinos et al.2024 · 13 citationsJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 2024;33(12):108015
Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries.39371125 · García-Marín, Luis M, Campos, Adrian I, Diaz-Torres, Santiago et al.2026 · 25 citationsmedRxiv : the preprint server for health sciences. 2024
Cross-Vendor Test-Retest Validation of Diffusion Tensor Image Analysis along the Perivascular Space (DTI-ALPS) for Evaluating Glymphatic System Function.37307817 · Liu, Xiaodan, Barisano, Giuseppe, Shao, Xingfeng et al.2024 · 122 citationsAging and disease. 2024;15(4):1885-1898
Quantitative assessment of enlarged perivascular spaces via deep-learning in community-based older adults reveals independent associations with vascular neuropathologies, vascular risk factors and cognition.39130513 · Javierre-Petit, Carles, Kontzialis, Marinos, Leurgans, Sue E et al.2025 · 9 citationsBrain communications. 2024;6(4):fcae252
Cerebral arteriolosclerosis, lacunar infarcts, and cognition in older Black adults.38988020 · Fleischman, Debra A, Arfanakis, Konstantinos, Leurgans, Sue E et al.2024 · 9 citationsAlzheimer's & dementia : the journal of the Alzheimer's Association. 2024;20(8):5375-5384
In vivo effect of LATE-NC on integrity of white matter connections to the hippocampus.38877688 · Heywood, Ashley, Stocks, Jane, Schneider, Julie A et al.2024 · 7 citationsAlzheimer's & dementia : the journal of the Alzheimer's Association. 2024;20(7):4401-4410
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