KY
Kejun Ying
AgingbioinformaticsEpigenesis, Geneticsystems biologyDNA MethylationgeneticsLongevityBiomarkerscs.LGAgeing
On Valency
published · living versionsW_62rs3ws9·v1 · currentpublished
ProteoCraft: Protein Design as Proposal-Verification Search
with Fang Wu, Hongbin Lin, Bingchen Duan, Yuchen Wang +22
1 version
Preprints & journals
47 papers in the corpus · 2019–2026Advancing aging biomarkers and intervention discovery at the TimePie Longevity Forum.42816658 · Ying, Kejun, Bie, Juntao, Chen, Guobing et al.2026 · 0 citationsNature aging. 2026;6(10):2054-2056
An immune world model for multiscale forecasting and therapeutic hypothesis generation2609.14709v1 · Taoyong Cui, Xi Wang, Zonghang Li et al.2026 · 0 citationsarXiv
ADMET-EvO: a self-evolving scientific agent for sustained research across heterogeneous tasks2609.10121v2 · Yiling Zhou, Yilin Wang, Jianmin Wang et al.2026 · 0 citationsarXiv
Integration of proteomic aging clocks in a phase 2a clinical trial supports simultaneous geroprotective assessment.42706338 · Zhavoronkov, Alex, Galkin, Fedor, Chen, Shan et al.2026 · 4 citationsNature biotechnology. 2026
Novel Exploratory Transcriptomic Candidates as Biomarkers and Cancer Hallmark Fingerprints for Ovarian Endometroid and Clear Cell Carcinomas in Women.42650243 · Kordowitzki, Pawel, Ying, Kejun2026 · 0 citationsAntioxidants (Basel, Switzerland). 2026;15(8)
Mammalian aging involves genome-wide splicing degeneration leading to functional decline.42427714 · Zhang, Sirui, Tyshkovskiy, Alexander, Ying, Kejun et al.2026 · 0 citationsbioRxiv : the preprint server for biology. 2026
Universal transcriptomic hallmarks of mammalian ageing and mortality.42203874 · Tyshkovskiy, Alexander, Kholdina, Daria, Davitadze, Maria et al.2026 · 30 citationsNature. 2026;654(8117):173-188
Proteo-R1: Reasoning Foundation Models for De Novo Protein Design2605.02937v2 · Fang Wu, Weihao Xuan, Heli Qi et al.2026 · 0 citationsICML 2026
OpenScientist: evaluating an open agentic AI co-scientist to accelerate biomedical discovery.41891004 · Roberts, Kaleigh F, Abrams, Zachary B, Cappelletti, Luca et al.2026 · 1 citationmedRxiv : the preprint server for health sciences. 2026
Anatomy of aging through organ-resolved multi-modal imaging and deep learning10.64898/2026.03.14.26348392v1 · Eames, A., Glubokov, D., Moldakozhayev, A. et al.2026 · 0 citationsmedRxiv
WITHDRAWN: MedOS: AI-XR-Cobot World Model for Clinical Perception and Action10.64898/2026.02.18.26345936v2 · Wu, Y. C., Yin, M., Shi, B. et al.2026 · 2 citationsmedRxiv
Integrative epigenetics and transcriptomics identify aging genes in human blood.41554691 · Moqri, Mahdi, Ying, Kejun, Poganik, Jesse R et al.2026 · 20 citationsNature communications. 2026;17(1):725
An unbiased comparison of 14 epigenetic clocks in relation to 174 incident disease outcomes.41402269 · Mavrommatis, Christos, Belsky, Daniel W, Ying, Kejun et al.2025 · 34 citationsNature communications. 2025;16(1):11164
Autonomous AI Agents Discover Aging Interventions from Millions of Molecular Profiles.41332661 · Ying, Kejun, Tyshkovskiy, Alexander, Moldakozhayev, Alibek et al.2025 · 22 citationsbioRxiv : the preprint server for biology. 2025
A unified framework for systematic curation and evaluation of aging biomarkers.41188602 · Ying, Kejun, Paulson, Seth, Eames, Alec et al.2025 · 56 citationsNature aging. 2025;5(11):2323-2339
ECloudGen: leveraging electron clouds as a latent variable to scale up structure-based molecular design.41094041 · Zhang, Odin, Jin, Jieyu, Wu, Zhenxing et al.2025 · 7 citationsNature computational science. 2025;5(11):1017-1028
Graph Neural Networks in Modern AI-Aided Drug Discovery.40959983 · Zhang, Odin, Lin, Haitao, Zhang, Xujun et al.2025 · 91 citationsChemical reviews. 2025;125(20):10001-10103
Circular RNAs as regulators and biomarkers of mammalian ovarian ageing.40676447 · Grzeczka, Arkadiusz, Iqbal, Sharif, Ying, Kejun et al.2026 · 0 citationsGeroScience. 2026;48(3):4769-4787
Disruption of the cerebrospinal fluid-plasma protein balance in cognitive impairment and aging.40665050 · Farinas, Amelia, Rutledge, Jarod, Bot, Veronica Augustina et al.2025 · 41 citationsNature medicine. 2025;31(8):2578-2589
An unbiased comparison of 14 epigenetic clocks in relation to 10-year onset of 174 disease outcomes in 18,859 individuals.40791724 · Mavrommatis, Christos, Belsky, Daniel W, Ying, Kejun et al.2025 · 4 citationsmedRxiv : the preprint server for health sciences. 2025
Biological Age, Aging Clocks, and the Interplay with Lymphoid Neoplasms: Mechanisms and Clinical Frontiers.40726806 · Wu, Xiaocan, Liu, Hanna, Ying, Kejun2026 · 1 citationLymphatics. 2025;3(3)
Invigorating discovery and clinical translation of aging biomarkers.40164770 · Jacques, Erik, Herzog, Chiara, Ying, Kejun et al.2026 · 10 citationsNature aging. 2025;5(4):539-543
Disagreement on foundational principles of biological aging.39660064 · Gladyshev, Vadim N, Anderson, Benjamin, Barlit, Hanna et al.2025 · 64 citationsPNAS nexus. 2024;3(12):pgae499
MethylGPT: a foundation model for the DNA methylome.39574641 · Ying, Kejun, Song, Jinyeop, Cui, Haotian et al.2025 · 30 citationsbioRxiv : the preprint server for biology. 2024
An Open Competition for Biomarkers of Aging.39554132 · Ying, Kejun, Paulson, Seth, Reinhard, Julian et al.2026 · 10 citationsbioRxiv : the preprint server for biology. 2024
Plasma protein-based organ-specific aging and mortality models unveil diseases as accelerated aging of organismal systems.39488213 · Goeminne, Ludger J E, Vladimirova, Anastasiya, Eames, Alec et al.2025 · 129 citationsCell metabolism. 2025;37(1):205-222.e6
Causal inference for epigenetic ageing.39472743 · Ying, Kejun2026 · 3 citationsNature reviews. Genetics. 2025;26(1):3
Depletion of loss-of-function germline mutations in centenarians reveals longevity genes.39424787 · Ying, Kejun, Castro, José P, Shindyapina, Anastasia V et al.2024 · 13 citationsNature communications. 2024;15(1):9030
Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity.39418098 · Lyu, Yu-Xuan, Fu, Qiang, Wilczok, Dominika et al.2024 · 44 citationsAging. 2024;16(20):12955-12976
High-dimensional Ageome Representations of Biological Aging across Functional Modules.39345525 · Ying, Kejun, Tyshkovskiy, Alexander, Chen, Qingwen et al.2026 · 10 citationsbioRxiv : the preprint server for biology. 2024
Imputed DNA methylation outperforms measured loci associations with smoking and chronological age10.1101/2024.09.05.611501v1 · Richmond, A., Mur, J., Harris, S. et al.2024 · 1 citationbioRxiv
Age-associated clonal B cells drive B cell lymphoma in mice.39117982 · Castro, José P, Shindyapina, Anastasia V, Barbieri, Alessandro et al.2024 · 17 citationsNature aging. 2024;4(10):1403-1417
Precious3GPT: Multimodal Multi-Species Multi-Omics Multi-Tissue Transformer for Aging Research and Drug Discovery10.1101/2024.07.25.605062v1 · Galkin, F., Naumov, V., Pushkov, S. et al.2024 · 15 citationsbioRxiv
PRC2-AgeIndex as a universal biomarker of aging and rejuvenation.39009581 · Moqri, Mahdi, Cipriano, Andrea, Simpson, Daniel J et al.2024 · 65 citationsNature communications. 2024;15(1):5956
Transcriptomic Hallmarks of Mortality Reveal Universal and Specific Mechanisms of Aging, Chronic Disease, and Rejuvenation10.1101/2024.07.04.601982v1 · Tyshkovskiy, A., Kholdina, D., Ying, K. et al.2024 · 27 citationsbioRxiv
The 18S rRNA Methyltransferase DIMT-1 Regulates Lifespan in the Germline Later in Life.38798397 · Hafiz Rothi, M, Sarkar, Gautam Chandra, Haddad, Joseph Al et al.2025 · 8 citationsbioRxiv : the preprint server for biology. 2024
Nature of epigenetic aging from a single-cell perspective.38724733 · Tarkhov, Andrei E, Lindstrom-Vautrin, Thomas, Zhang, Sirui et al.2024 · 84 citationsNature aging. 2024;4(6):854-870
Plasma-based organ-specific aging and mortality models unveil diseases as accelerated aging of organismal systems10.1101/2024.04.08.24305469v1 · Goeminne, L. J. E., Eames, A. W., Tyshkovskiy, A. et al.2024 · 10 citationsmedRxiv
Validation of biomarkers of aging.38355974 · Moqri, Mahdi, Herzog, Chiara, Poganik, Jesse R et al.2024 · 339 citationsNature medicine. 2024;30(2):360-372
Causality-enriched epigenetic age uncouples damage and adaptation.38243142 · Ying, Kejun, Liu, Hanna, Tarkhov, Andrei E et al.2024 · 215 citationsNature aging. 2024;4(2):231-246
TIME-seq reduces time and cost of DNA methylation measurement for epigenetic clock construction.38200273 · Griffin, Patrick T, Kane, Alice E, Trapp, Alexandre et al.2024 · 25 citationsNature aging. 2024;4(2):261-274
Acarbose suppresses symptoms of mitochondrial disease in a mouse model of Leigh syndrome.37365290 · Bitto, Alessandro, Grillo, Anthony S, Ito, Takashi K et al.2023 · 19 citationsNature metabolism. 2023;5(6):955-967
Epigenetic profiling and incidence of disrupted development point to gastrulation as aging ground zero in Xenopus laevis10.1101/2022.08.02.502559v1 · Zhang, B., Tarkhov, A. E., Ratzan, W. et al.2022 · 5 citationsbioRxiv
Genetic and phenotypic analysis of the causal relationship between aging and COVID-19.35602207 · Ying, Kejun, Zhai, Ranran, Pyrkov, Timothy V et al.2026 · 33 citationsCommunications medicine. 2021;1:35
Total genetic contribution assessment across the human genome.33990588 · Li, Ting, Ning, Zheng, Yang, Zhijian et al.2021 · 8 citationsNature communications. 2021;12(1):2845
Genetic and Phenotypic Evidence for the Causal Relationship Between Aging and COVID-1910.1101/2020.08.06.20169854v2 · Ying, K., Zhai, R., Pyrkov, T. V. et al.2020 · 5 citationsmedRxiv
Phosphorylation of PLIN3 by AMPK promotes dispersion of lipid droplets during starvation.30430421 · Zhu, Jianxi, Xu, Mingyang, Liu, Yi et al.2020 · 29 citationsProtein & cell. 2019;10(5):382-387
Career total: 65 works. 47 are in this corpus.
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