RA
Robert G. Alberstein
cs.LGComplementarity Determining RegionsProtein Engineeringq-bio.BMAldehyde-LyasesAntibodiesantibodyAntibodyAntibody AffinityAntigens
On Valency
published · living versionsW_fwzmgj9y·v1 · currentpublished
iGC: Antibody Optimization via Reinforcement Learning over a Learned Somatic Hypermutation Prior
with Thao Nguyen, Ewa Nowara, Homa MohammadiPeyhani, Holly R. Steach +8
1 version
Preprints & journals
17 papers in the corpus · 2015–2025Tokenizing loops of antibodies.41936024 · Fang, Ada, Alberstein, Robert G, Kelow, Simon et al.2026 · 0 citationsmAbs. 2026;18(1):2645271
Conformation-aware structure prediction of antigen-recognizing immune proteins.41378904 · Dreyer, Frédéric A, Ludwiczak, Jan, Martinkus, Karolis et al.2025 · 4 citationsmAbs. 2026;18(1):2602217
Lab-in-the-loop therapeutic antibody design with deep learning10.1101/2025.02.19.639050v3 · Frey, N. C., Hotzel, I., Stanton, S. D. et al.2025 · 28 citationsbioRxiv
Generalists vs. Specialists: Evaluating LLMs on Highly-Constrained Biophysical Sequence Optimization Tasks2410.22296v5 · Angelica Chen, Samuel D. Stanton, Frances Ding et al.2024 · 1 citationarXiv
Rapid affinity optimization of an anti-TREM2 clinical lead antibody by cross-lineage immune repertoire mining.39333507 · Hsiao, Yi-Chun, Wallweber, Heidi Ackerly, Alberstein, Robert G et al.2024 · 8 citationsNature communications. 2024;15(1):8382
Designed 2D protein crystals as dynamic molecular gatekeepers for a solid-state device.39068153 · Vijayakumar, Sanahan, Alberstein, Robert G, Zhang, Zhiyin et al.2024 · 8 citationsNature communications. 2024;15(1):6326
Closed-Form Test Functions for Biophysical Sequence Optimization Algorithms2407.00236v1 · Samuel Stanton, Robert Alberstein, Nathan Frey et al.2024 · 0 citationsarXiv
Discrete Orientations of Interfacial Waters Direct Crystallization of Mica-Binding Proteins.36573690 · Alberstein, Robert G, Prelesnik, Jesse L, Nakouzi, Elias et al.2023 · 15 citationsThe journal of physical chemistry letters. 2023;14(1):80-87
Design principles of protein switches.34537489 · Alberstein, Robert G, Guo, Amy B, Kortemme, Tanja2022 · 56 citationsCurrent opinion in structural biology. 2022;72:71-78
Assembly of a patchy protein into variable 2D lattices via tunable multiscale interactions.32724112 · Zhang, Shuai, Alberstein, Robert G, De Yoreo, James J et al.2020 · 64 citationsNature communications. 2020;11(1):3770
Constructing protein polyhedra via orthogonal chemical interactions.31969701 · Golub, Eyal, Subramanian, Rohit H, Esselborn, Julian et al.2020 · 133 citationsNature. 2020;578(7793):172-176
Self-Assembly of a Designed Nucleoprotein Architecture through Multimodal Interactions.30555911 · Subramanian, Rohit H, Smith, Sarah J, Alberstein, Robert G et al.2020 · 24 citationsACS central science. 2018;4(11):1578-1586
Determining the Structural and Energetic Basis of Allostery in a De Novo Designed Metalloprotein Assembly.29996654 · Churchfield, Lewis A, Alberstein, Robert G, Williamson, Laura M et al.2019 · 24 citationsJournal of the American Chemical Society. 2018;140(31):10043-10053
Engineering the entropy-driven free-energy landscape of a dynamic nanoporous protein assembly.29713036 · Alberstein, Robert, Suzuki, Yuta, Paesani, Francesco et al.2019 · 67 citationsNature chemistry. 2018;10(7):732-739
Observations of the birth of crystals.29620750 · Alberstein, Robert G, Tezcan, F Akif2018 · 13 citationsNature. 2018;556(7699):41-42
Molecular lock regulates binding of glycine to a primitive NMDA receptor.27791085 · Yu, Alvin, Alberstein, Robert, Thomas, Alecia et al.2018 · 33 citationsProceedings of the National Academy of Sciences of the United States of America. 2016;113(44):E6786-E6795
Glycine activated ion channel subunits encoded by ctenophore glutamate receptor genes.26460032 · Alberstein, Robert, Grey, Richard, Zimmet, Austin et al.2016 · 49 citationsProceedings of the National Academy of Sciences of the United States of America. 2015;112(44):E6048-57
Career total: 25 works. 17 are in this corpus.
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