MC
Mark Chen
COVID-19SARS-CoV-2Disease Outbreakscs.LGSingaporecs.CVHIVInfluenza A Virus, H1N1 SubtypePandemicsHealth Knowledge, Attitudes, Practice
On Valency
published · living versionsW_3seyyh2p·v1 · currentpublished
Evaluating Large Language Models Trained on Code
with Jerry Tworek, Heewoo Jun, Qiming Yuan, Henrique Ponde de Oliveira Pinto +53
1 version
Preprints & journals
197 papers in the corpus · 1996–2026Associations of age, COVID-19 vaccination, and SARS-CoV-2 infection history with health-related quality of life in a community-based longitudinal cohort in Singapore.42748761 · Huang, Zhilian, Se Soh, Alexius Matthias, Zeng, Kangwei et al.2026 · 0 citationsJournal of infection and public health. 2026;19(10):103359
Big Bird: Resilient Privacy Budgeting Across Untrusted Web Domains2506.05290v4 · Pierre Tholoniat, Alison Caulfield, Giorgio Cavicchioli et al.2025 · 0 citationsSOSP '26: Proceedings of the ACM SIGOPS 32nd Symposium on Operating Systems Principles. September 29th - October 2nd, 2026. Prague, Czech Republic
Harnessing Participatory Surveillance Cohorts and Proxy Indicators to Dynamically Track Epidemic Trends and Undiagnosed COVID-19 Infections in Singapore: Longitudinal Observational Study.42269090 · Soh, Sheng En Alexius Matthias, Aung, Aung Hein, Ong, Wei Ling Brenda et al.2026 · 0 citationsJournal of medical Internet research. 2026;28:e85608
CityOS: Privacy Architecture for Urban Sensing2605.02886v1 · Giorgio Cavicchioli, Mark Chen, Navid Salami Pargoo et al.2026 · 0 citationsarXiv
OpenAI o1 System Card2412.16720v2 · OpenAI: Aaron Jaech, Adam Kalai, Adam Lerer et al.2024 · 44 citationsarXiv
Chain of Thought Monitorability: A New and Fragile Opportunity for AI Safety2507.11473v2 · Tomek Korbak, Mikita Balesni, Elizabeth Barnes et al.2025 · 2 citationsarXiv
Prevalence, drivers and surveillance of antibiotic resistance and antibiotic use in rural China: Interdisciplinary study.37556412 · Lambert, H, Shen, X, Chai, J et al.2025 · 11 citationsPLOS global public health. 2023;3(8):e0001232
Trust in government vaccine recommendations during the Covid-19 pandemic in Singapore: A longitudinal survey study.39721353 · Sheldenkar, Anita, Ling, Tng Pei, Schulz, Peter Johannes et al.2025 · 1 citationVaccine. 2025;45:126643
Competitive Programming with Large Reasoning Models2502.06807v2 · OpenAI: Ahmed El-Kishky, Alexander Wei, Andre Saraiva et al.2025 · 6 citationsarXivon Valency
Differential escape of neutralizing antibodies by SARS-CoV-2 Omicron and pre-emergent sarbecoviruses.35233568 · Wang, Lin-Fa, Tan, Chee Wah, Chia, Wan Ni et al.2024 · 14 citationsResearch square. 2022
An updated framework for SARS-CoV-2 variants reflects the unpredictability of viral evolution.38720002 · Subissi, Lorenzo, Otieno, James Richard, Worp, Nathalie et al.2024 · 28 citationsNature medicine. 2024;30(9):2400-2403
Distinctive serotypes of SARS-related coronaviruses defined by convalescent sera from unvaccinated individuals.38994526 · Tan, Chee Wah, Zhu, Feng, Chia, Wan Ni et al.2024 · 44 citationshLife. 2023;1(1):26-34
Can platform use patterns be an indicator of HIV-related risk and sub-group heterogeneity among men who have sex with men in Singapore: a latent class analysis.38737858 · Tavitian-Exley, Isabel, Hao, Ying, Chen, Mark I-C et al.2024 · 0 citationsFrontiers in public health. 2024;12:1330282
Impact of Delta Variant and Vaccination on SARS-CoV-2 Secondary Attack Rate Among Household Close Contacts.34746899 · Ng, Oon Tek, Koh, Vanessa, Chiew, Calvin J et al.2024 · 73 citationsThe Lancet regional health. Western Pacific. 2021;17:100299
DUSP4 modulates RIG-I- and STING-mediated IRF3-type I IFN response.38383887 · Jiao, Huipeng, James, Sharmy J, Png, Chin Wen et al.2024 · 19 citationsCell death and differentiation. 2024;31(3):280-291
Mental health and resilience after the covid-19 pandemic: a multi-ethnic longitudinal survey.38007456 · Sumner, Jennifer, Chen, Mark, En, Alexius Matthias Soh Sheng et al.2024 · 11 citationsBMC public health. 2023;23(1):2340
Examining resilience in Singapore in the face of COVID-19 community restrictions.38094705 · Chan, Alyssa Yenyi, Tan, Chuen Seng, Chan, Felicia Jia Hui et al.2023 · 3 citationsFrontiers in psychology. 2023;14:1082148
Influenza A and B Viruses in Fine Aerosols of Exhaled Breath Samples from Patients in Tropical Singapore.37896810 · Chow, Vincent T K, Tay, Douglas Jie Wen, Chen, Mark I C et al.2023 · 14 citationsViruses. 2023;15(10)
Severity of SARS-CoV-2 Omicron XBB subvariants in Singapore.37554470 · Pung, Rachael, Kong, Xin Peng, Cui, Lin et al.2023 · 26 citationsThe Lancet regional health. Western Pacific. 2023;37:100849
Potent pan huACE2-dependent sarbecovirus neutralizing monoclonal antibodies isolated from a BNT162b2-vaccinated SARS survivor.37494438 · Chia, Wan Ni, Tan, Chee Wah, Tan, Aaron Wai Kit et al.2023 · 15 citationsScience advances. 2023;9(30):eade3470
Consistency Models2303.01469v2 · Yang Song, Prafulla Dhariwal, Mark Chen et al.2023 · 23 citationsarXiv
Severity of SARS-CoV-2 Omicron XBB subvariants in Singapore10.1101/2023.05.04.23289510v1 · Pung, R., Kong, X. P., Lin, C. et al.2023 · 26 citationsmedRxiv
Erratum to "Impact of delta variant and vaccination on SARS-CoV-2 secondary attack rate among household close contacts" [The Lancet Regional Health - Western Pacific 17 (2021) 100299].36945675 · Ng, Oon Tek, Koh, Vanessa, Chiew, Calvin J et al.2023 · 1 citationThe Lancet regional health. Western Pacific. 2023;33:100748
Evaluating the Downstream Revenues of a Self-Pay Bi-Parametric Prostate MRI Program.36195163 · Parikh, Keval D, Declouette, Brandon, Chen, Mark et al.2023 · 0 citationsUrology. 2023;171:109-114
Point-E: A System for Generating 3D Point Clouds from Complex Prompts2212.08751v1 · Alex Nichol, Heewoo Jun, Prafulla Dhariwal et al.2022 · 163 citationsarXiv
Conserved longitudinal alterations of anti-S-protein IgG subclasses in disease progression in initial ancestral Wuhan and vaccine breakthrough Delta infections.36483199 · Goh, Yun Shan, Fong, Siew-Wai, Hor, Pei Xiang et al.2022 · 1 citationFrontiers in microbiology. 2022;13:1043049
Exploring theory-based behavioral interventions promoting COVID-19 prevention and healthcare-seeking for migrant worker men in Singapore: a qualitative study.36401178 · Hildon, Zoe Jane-Lara, Panchapakesan, Chitra, Hasan, Md Tahmid et al.2022 · 1 citationBMC public health. 2022;22(1):2113
DYNAMIC cohort study evaluating metabolic predictors of influenza vaccine immune response in older adults.36319665 · Sadarangani, Sapna P, Young, Barnaby E, Lian, Weixiang et al.2022 · 8 citationsNPJ vaccines. 2022;7(1):135
SARS-CoV-2 Omicron variant emerged under immune selection.36195753 · Tan, Chee Wah, Chia, Wan Ni, Zhu, Feng et al.2022 · 60 citationsNature microbiology. 2022;7(11):1756-1761
Determining the Prevalence and Correlates of COVID-19 Booster Vaccine Hesitancy in the Singapore Population Following the Completion of the Primary Vaccination Series.35891252 · Tan, Kevin Y K, Soh, Alexius S E, Ong, Brenda W L et al.2022 · 24 citationsVaccines. 2022;10(7)
Efficient Training of Language Models to Fill in the Middle2207.14255v1 · Mohammad Bavarian, Heewoo Jun, Nikolas Tezak et al.2022 · 42 citationsarXiv
A Decade of Success in Melanoma Immunotherapy and Targeted Therapy: What Every Radiologist Should Know.35675685 · Chen, Mark, Smith, Daniel A, Yoon, Justin G et al.2022 · 5 citationsJournal of computer assisted tomography. 2022;46(4):621-632
An early warning system for emerging SARS-CoV-2 variants.35637337 · Subissi, Lorenzo, von Gottberg, Anne, Thukral, Lipi et al.2022 · 93 citationsNature medicine. 2022;28(6):1110-1115
Viral Load of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Respiratory Aerosols Emitted by Patients With Coronavirus Disease 2019 (COVID-19) While Breathing, Talking, and Singing.34358292 · Coleman, Kristen K, Tay, Douglas Jie Wen, Tan, Kai Sen et al.2022 · 249 citationsClinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2022;74(10):1722-1728
Accuracy of a Rapid Multiplex Polymerase Chain Reaction Plus a Chromogenic Phenotypic Test Algorithm for Detection of Extended-Spectrum β-Lactamase and Carbapenemase-Producing Gram-Negative Bacilli in Positive Blood Culture Bottles.34554228 · Ong, Sean Wei Xiang, Hon, Pei Yun, Wee, Sharon Syn Hui et al.2022 · 2 citationsClinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2022;74(10):1850-1854
Effect of a Popular Web Drama Video Series on HIV and Other Sexually Transmitted Infection Testing Among Gay, Bisexual, and Other Men Who Have Sex With Men in Singapore: Community-Based, Pragmatic, Randomized Controlled Trial.35522470 · Tan, Rayner Kay Jin, Koh, Wee Ling, Le, Daniel et al.2022 · 15 citationsJournal of medical Internet research. 2022;24(5):e31401
Dynamics of SARS-CoV-2 neutralising antibody responses and duration of immunity: a longitudinal study.33778792 · Chia, Wan Ni, Zhu, Feng, Ong, Sean Wei Xiang et al.2022 · 403 citationsThe Lancet. Microbe. 2021;2(6):e240-e249
Hierarchical Text-Conditional Image Generation with CLIP Latents2204.06125v1 · Aditya Ramesh, Prafulla Dhariwal, Alex Nichol et al.2022 · 2,256 citationsarXiv
Severity and burden of hand, foot and mouth disease in Asia: a modelling study.29564154 · Koh, Wee Ming, Badaruddin, Hishamuddin, La, Hanh et al.2022 · 129 citationsBMJ global health. 2018;3(1):e000442
GLIDE: Towards Photorealistic Image Generation and Editing with Text-Guided Diffusion Models2112.10741v3 · Alex Nichol, Prafulla Dhariwal, Aditya Ramesh et al.2021 · 989 citationsarXiv
Sensitive detection of total anti-Spike antibodies and isotype switching in asymptomatic and symptomatic individuals with COVID-19.33495757 · Goh, Yun Shan, Chavatte, Jean-Marc, Lim Jieling, Alicia et al.2022 · 53 citationsCell reports. Medicine. 2021;2(2):100193
Prevalence of measles antibodies among migrant workers in Singapore: a serological study to identify susceptible population subgroups.35078426 · Ang, Li Wei, Gao, Qi, Cui, Lin et al.2022 · 4 citationsBMC infectious diseases. 2022;22(1):88
An Updated Assessment of Chronic Hepatitis B Prevalence Among Foreign-Born Persons Living in the United States.33655536 · Wong, Robert J, Brosgart, Carol L, Welch, Sue et al.2022 · 145 citationsHepatology (Baltimore, Md.). 2021;74(2):607-626
HIV Pre-Exposure Prophylaxis, Condoms, or Both? Insights on Risk Compensation Through a Discrete Choice Experiment and Latent Class Analysis Among Men Who Have Sex With Men.33933241 · Tan, Rayner Kay Jin, Wang, Yi, Prem, Kiesha et al.2022 · 14 citationsValue in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research. 2021;24(5):714-723
Potential interactions between the pathways to diagnosis of HIV and other STIs and HIV self-testing: insights from a qualitative study of gay, bisexual and other men who have sex with men in Singapore.33087479 · Tan, Rayner Kay Jin, Chan, Yin Ying, Bin Ibrahim, Muhamad Alif et al.2021 · 7 citationsSexually transmitted infections. 2021;97(3):215-220
Perceptions of an HIV self-testing intervention and its potential role in addressing the barriers to HIV testing among at-risk heterosexual men: a qualitative analysis.33452131 · Tan, Yi-Roe, Kaur, Nashwinder, Ye, Angeline Jiajun et al.2021 · 25 citationsSexually transmitted infections. 2021;97(7):514-520
Pan-Sarbecovirus Neutralizing Antibodies in BNT162b2-Immunized SARS-CoV-1 Survivors.34407341 · Tan, Chee-Wah, Chia, Wan-Ni, Young, Barnaby E et al.2021 · 237 citationsThe New England journal of medicine. 2021;385(15):1401-1406
Rapid measurement of SARS-CoV-2 spike T cells in whole blood from vaccinated and naturally infected individuals.34623327 · Tan, Anthony T, Lim, Joey Me, Le Bert, Nina et al.2021 · 127 citationsThe Journal of clinical investigation. 2021;131(17)
Differentiating coronavirus disease 2019 (COVID-19) from influenza and dengue.34611200 · Thein, Tun-Linn, Ang, Li Wei, Young, Barnaby Edward et al.2021 · 41 citationsScientific reports. 2021;11(1):19713
Cross-sectional study of prevalence and risk factors, and a cost-effectiveness evaluation of screening and preventive treatment strategies for latent tuberculosis among migrants in Singapore.34266845 · Lim, Vanessa W, Wee, Hwee Lin, Lee, Phoebe et al.2021 · 21 citationsBMJ open. 2021;11(7):e050629
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