SO
Stig W. Omholt
Models, BiologicalModels, GeneticPhenotypePolymorphism, Single NucleotideModels, CardiovascularComputer SimulationGene Expression RegulationGenetic VariationNeuronsBiological Evolution
On Valency
published · living versionsW_hegwxta4·v1 · currentpublished
Electrodiffusive model for astrocytic and neuronal ion concentration dynamics
with Geir Halnes, Ivar Østby, Klas H. Pettersen, Gaute T. Einevoll
1 version
Preprints & journals
103 papers in the corpus · 1995–2026High reelin expression may explain why a subgroup of entorhinal cortex neurons functions as an initial nucleation site of Alzheimer's disease.42640981 · Kobro-Flatmoen, Asgeir, Hussan, Jagir R, Hunter, Peter J et al.2026 · 0 citationsPLoS computational biology. 2026;22(8):e1014532
A DNA mass conservation mechanism underpins cellular mtDNA number regulation10.64898/2026.07.08.737183v1 · Hussan, J. R., Kobro-Flatmoen, A., Ruoff, P. et al.2026 · 0 citationsbioRxiv
Genetic Markers for Tracing Introgression of Farmed Atlantic Salmon (Salmo salar) in Wild Conspecifics.41137457 · Hagen, Ingerid Julie, Hindar, Kjetil, Bolstad, Geir Hysing et al.2025 · 2 citationsMolecular ecology resources. 2026;26(1):e70065
Correction: Bnip3 expression is strongly associated with reelin‑positive entorhinal cortex layer II neurons.40608145 · Omholt, Stig W, Lejneva, Raissa, Donate, Maria Jose Lagartos et al.2025 · 0 citationsBrain structure & function. 2025;230(6):109
High reelin expression can explain why the entorhinal cortex is a cradle for Alzheimer's disease10.1101/2025.06.04.655278v1 · Kobro-Flatmoen, A., Hussan, J. R., Hunter, P. J. et al.2025 · 0 citationsbioRxiv
Intraneuronal binding of amyloid beta with reelin-Implications for the onset of Alzheimer's disease.39775030 · Kobro-Flatmoen, Asgeir, Omholt, Stig W2025 · 3 citationsPLoS computational biology. 2025;21(1):e1012709
Bnip3 expression is strongly associated with reelin-positive entorhinal cortex layer II neurons.38916724 · Omholt, Stig W, Lejneva, Raissa, Donate, Maria Jose Lagartos et al.2024 · 7 citationsBrain structure & function. 2024;229(7):1617-1629
Intraneuronal binding of amyloid beta with reelin -implications for the onset of Alzheimer's disease10.1101/2023.10.30.564686v1 · Kobro-Flatmoen, A., Omholt, S. W.2023 · 3 citationsbioRxiv
Bnip3 expression is strongly associated with reelin-positive entorhinal cortex layer II neurons10.1101/2023.10.19.562876v1 · Omholt, S. W., Lejneva, R., Donate, M. J. L. et al.2023 · 7 citationsbioRxiv
Wearable technology and the cardiovascular system: the future of patient assessment.37391266 · Williams, Gareth J, Al-Baraikan, Abdulaziz, Rademakers, Frank E et al.2023 · 143 citationsThe Lancet. Digital health. 2023;5(7):e467-e476
Genetically controlled mtDNA deletions prevent ROS damage by arresting oxidative phosphorylation.35801695 · Stenberg, Simon, Li, Jing, Gjuvsland, Arne B et al.2022 · 34 citationseLife. 2022;11
Comparing the impact of vaccination strategies on the spread of COVID-19, including a novel household-targeted vaccination strategy.35108311 · Voigt, André, Omholt, Stig, Almaas, Eivind2022 · 17 citationsPloS one. 2022;17(2):e0263155
Aging as a consequence of selection to reduce the environmental risk of dying.34031251 · Omholt, Stig W, Kirkwood, Thomas B L2021 · 12 citationsProceedings of the National Academy of Sciences of the United States of America. 2021;118(22)
Propagation of genetic variation in gene regulatory networks.23997378 · Plahte, Erik, Gjuvsland, Arne B, Omholt, Stig W2021 · 5 citationsPhysica D. Nonlinear phenomena. 2013;256-257:7-20
Genetically controlled mtDNA editing prevents ROS damage by arresting oxidative phosphorylation10.1101/2020.11.20.391110v2 · Stenberg, S., Li, J., Gjuvsland, A. B. et al.2020 · 2 citationsbioRxiv
Comparing the impact of vaccination strategies on spread of COVID-19, including a novel household-targeted vaccination strategy10.1101/2021.01.30.21250828v2 · Voigt, A., Omholt, S. W., Almaas, E.2021 · 3 citationsmedRxiv
Correction to: Containing pandemics through targeted testing of households.34229601 · Voigt, André, Martyushenko, Nikolay, Karlsen, Emil et al.2021 · 0 citationsBMC infectious diseases. 2021;21(1):653
Containing pandemics through targeted testing of households.34107917 · Voigt, André, Martyushenko, Nikolay, Karlsen, Emil et al.2021 · 8 citationsBMC infectious diseases. 2021;21(1):548
Containing pandemics through targeted testing of households10.1101/2020.10.30.20219766v1 · Voigt, A., Martyushenko, N., Karlsen, E. et al.2020 · 8 citationsmedRxiv
Cardiovascular models for personalised medicine: Where now and where next?31554575 · Hose, D Rodney, Lawford, Patricia V, Huberts, Wouter et al.2020 · 70 citationsMedical engineering & physics. 2019;72:38-48
Early developmental processes in the fertilised honeybee (Apis mellifera) oocyte.12770307 · Yu, R, Omholt, S W.2019 · 25 citationsJournal of insect physiology. 1999;45(8):763-767
Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow.28847942 · Holter, Karl Erik, Kehlet, Benjamin, Devor, Anna et al.2018 · 316 citationsProceedings of the National Academy of Sciences of the United States of America. 2017;114(37):9894-9899
A novel role for pigment genes in the stress response in rainbow trout (Oncorhynchus mykiss).27373344 · Khan, Uniza Wahid, Øverli, Øyvind, Hinkle, Patricia M et al.2018 · 30 citationsScientific reports. 2016;6:28969
Functional Annotation of All Salmonid Genomes (FAASG): an international initiative supporting future salmonid research, conservation and aquaculture.28655320 · Macqueen, Daniel J, Primmer, Craig R, Houston, Ross D et al.2018 · 109 citationsBMC genomics. 2017;18(1):484
Scan-o-matic: High-Resolution Microbial Phenomics at a Massive Scale.27371952 · Zackrisson, Martin, Hallin, Johan, Ottosson, Lars-Göran et al.2017 · 107 citationsG3 (Bethesda, Md.). 2016;6(9):3003-14
Roadmap for cardiovascular circulation model.27506597 · Safaei, Soroush, Bradley, Christopher P, Suresh, Vinod et al.2017 · 40 citationsThe Journal of physiology. 2016;594(23):6909-6928
Disentangling genetic and epigenetic determinants of ultrafast adaptation.27979908 · Gjuvsland, Arne B, Zörgö, Enikö, Samy, Jeevan Ka et al.2017 · 9 citationsMolecular systems biology. 2016;12(12):892
Functional Analysis of All Salmonid Genomes (FAASG): an international initiative supporting future salmonid research, conservation and aquaculture10.1101/095737v1 · Macqueen, D. J., Primmer, C. R., Houston, R. D. et al.2016 · 7 citationsbioRxiv
The Atlantic salmon genome provides insights into rediploidization.27088604 · Lien, Sigbjørn, Koop, Ben F, Sandve, Simen R et al.2016 · 1,191 citationsNature. 2016;533(7602):200-5
Towards causally cohesive genotype-phenotype modelling for characterization of the soft-tissue mechanics of the heart in normal and pathological geometries.25833237 · Nordbø, Øyvind, Gjuvsland, Arne B, Nermoen, Anders et al.2016 · 3 citationsJournal of the Royal Society, Interface. 2015;12(106)
High-throughput biochemical fingerprinting of Saccharomyces cerevisiae by Fourier transform infrared spectroscopy.25706524 · Kohler, Achim, Böcker, Ulrike, Shapaval, Volha et al.2015 · 42 citationsPloS one. 2015;10(2):e0118052
Scan-o-matic: high-resolution microbial phenomics at a massive scale10.1101/031443v1 · Martin Zackrisson, Johan Hallin, Lars-Göran Ottosson et al.2015 · 107 citationsbioRxiv
150 years of the mass action law.25569257 · Voit, Eberhard O, Martens, Harald A, Omholt, Stig W2015 · 189 citationsPLoS computational biology. 2015;11(1):e1004012
Concerted evolution of life stage performances signals recent selection on yeast nitrogen use.25349282 · Ibstedt, Sebastian, Stenberg, Simon, Bagés, Sara et al.2015 · 57 citationsMolecular biology and evolution. 2015;32(1):153-61
Arterial stiffening provides sufficient explanation for primary hypertension1305.0727v2 · Klas H. Pettersen, Scott M. Bugenhagen, Javaid Nauman et al.2013 · 49 citationsarXivon Valency
A computational pipeline for quantification of mouse myocardial stiffness parameters.25129018 · Nordbø, Oyvind, Lamata, Pablo, Land, Sander et al.2015 · 16 citationsComputers in biology and medicine. 2014;53:65-75
Evolution evolves: physiology returns to centre stage.24882808 · Noble, Denis, Jablonka, Eva, Joyner, Michael J et al.2015 · 143 citationsThe Journal of physiology. 2014;592(11):2237-44
The evolution and functional divergence of the beta-carotene oxygenase gene family in teleost fish--exemplified by Atlantic salmon.24583166 · Helgeland, Hanna, Sandve, Simen Rød, Torgersen, Jacob Seilø et al.2014 · 24 citationsGene. 2014;543(2):268-74
Effect of regulatory architecture on broad versus narrow sense heritability.23671414 · Wang, Yunpeng, Vik, Jon Olav, Omholt, Stig W et al.2014 · 12 citationsPLoS computational biology. 2013;9(5):e1003053
Electrodiffusive model for astrocytic and neuronal ion concentration dynamics1304.7782v2 · Geir Halnes, Ivar \Ostby, Klas H. Pettersen et al.2013 · 88 citationsarXivon Valency
A computational analysis of the long-term regulation of arterial pressure.24555102 · Beard, Daniel A, Pettersen, Klas H, Carlson, Brian E et al.2014 · 37 citationsF1000Research. 2013;2:208
A vision and strategy for the virtual physiological human: 2012 update.24427536 · Hunter, Peter, Chapman, Tara, Coveney, Peter V et al.2014 · 89 citationsInterface focus. 2013;3(2):20130004
From sequence to consequence and back.23022209 · Omholt, Stig W2013 · 23 citationsProgress in biophysics and molecular biology. 2013;111(2-3):75-82
Monotonicity is a key feature of genotype-phenotype maps.24223579 · Gjuvsland, Arne B, Wang, Yunpeng, Plahte, Erik et al.2013 · 25 citationsFrontiers in genetics. 2013;4:216
Effects of various breeding strategies on diploid drone frequency and quantitative traits in a honey bee population.24178012 · Omholt, S W, Adnøy, T2013 · 11 citationsTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik. 1994;89(6):687-92
Life-history evolution and the polyphenic regulation of somatic maintenance and survival.24053071 · Flatt, Thomas, Amdam, Gro V, Kirkwood, Thomas B L et al.2013 · 122 citationsThe Quarterly review of biology. 2013;88(3):185-218
Bridging the genotype-phenotype gap: what does it take?23401613 · Gjuvsland, Arne B, Vik, Jon Olav, Beard, Daniel A et al.2013 · 116 citationsThe Journal of physiology. 2013;591(8):2055-66
Ancient evolutionary trade-offs between yeast ploidy states.23555297 · Zörgö, Enikö, Chwialkowska, Karolina, Gjuvsland, Arne B et al.2013 · 106 citationsPLoS genetics. 2013;9(3):e1003388
Is the brain water channel aquaporin-4 a pathogenetic factor in idiopathic intracranial hypertension? Results from a combined clinical and genetic study in a Norwegian cohort.21914143 · Kerty, Emilia, Heuser, Kjell, Indahl, Ulf G et al.2013 · 41 citationsActa ophthalmologica. 2013;91(1):88-91
Understanding the melanocyte distribution in human epidermis: an agent-based computational model approach.22792296 · Thingnes, Josef, Lavelle, Timothy J, Hovig, Eivind et al.2013 · 41 citationsPloS one. 2012;7(7):e40377
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