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Helical mesoporous silica as an inorganic heterogeneous chiral trigger for asymmetric autocatalysis with amplification of enantiomeric excess

Tsuneomi Kawasaki, Yuko Araki, Kunihiko Hatase, Kenta Suzuki, Arimasa Matsumoto

Published Mar 16, 2015Fresh — added to the Hub within the last 30 daysv17 min read

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Abstract

P and M -Helical mesoporous silica was found to act as a chiral inorganic trigger for asymmetric autocatalysis to afford ( S ) and ( R )-pyrimidyl alkanol with up to >99.5% ee, respectively.

Helical mesoporous silica as an inorganic heterogeneous chiral trigger for asymmetric autocatalysis with amplification of enantiomeric excess†

Tsuneomi Kawasaki; Yuko Araki; Kunihiko Hatase; Kenta Suzuki; Arimasa Matsumoto; Toshiyuki Yokoi; Yoshihiro Kubota; Takashi Tatsumi; Kenso Soai

Mesoporous silica has been used as a heterogeneous support for catalysts; however, asymmetric induction by the helicity of inorganic mesoporous silica itself has not yet been achieved. $P$ - and $M$ -helical mesoporous silica was found to act as a chiral inorganic trigger for asymmetric autocatalysis to afford $(S)$ and $(R)$ -pyrimidyl alkanol with >99.5% ee, respectively.

Catalytic enantioselective synthesis has attracted much attention in the fields of materials science and pharmaceuticals, because it is a useful method for synthesizing a large amount of a chiral compound from an initial small amount of chiral compound.[1] From an environmental and economic point of view, asymmetric synthesis using heterogeneous inorganic materials is an emerging area, because these catalysts can be separated from the reaction mixture easily and their thermal and mechanical stability allows for the recovery and reuse of the catalyst.[2, 3]

On the other hand, research into well-ordered mesoporous materials has become a “hot area” in materials science[4] because of their versatile applications in areas such as catalysis, adsorption, and drug delivery systems.[5] Their extremely large surface area, uniform pore size, and well-defined pore shape enable them to act as selective catalysts. There are some examples of chiral catalyst supported on achiral mesoporous silica.[6] However, to the best of our knowledge, there has been no report on asymmetric reaction induced by the chirality of inorganic helical mesoporous silica itself. Therefore, the use of mesoporous materials with a chiral inorganic framework presents a challenge in the field of asymmetric catalysis.

One of us synthesized chiral mesoporous silica using $N$ -myristoyl alanine as a chiral anionic surfactant, which has a twisted hexagonal rod-like morphology, with dimensions of diameter = 130–180 nm and length = 1–6 μm.[7] Right-handed enriched $(P)$ -helical mesoporous silica has been produced from a surfactant derived from $D$ -alanine. In contrast, the $L$ -isomer afforded left-handed enriched $(M)$ -helical mesoporous silica (Figure 1). To the best of our knowledge, there have been no reports on mesoporous silica mediated asymmetric synthesis in which the chiral inorganic structure induces the enantioselectivity.

Schematic representation and SEM images of helical mesoporous silica — Figure 1. Helical mesoporous silica. (a) A schematic representation of the stereochemical relationship between a chiral surfactant and the handedness of the helical mesoporous silica, and SEM images of (b) right-handed enriched $(P)$ - and (c) left-handed enriched $(M)$ -mesoporous silica.

Meanwhile, we have continued to study asymmetric autocatalysis with the amplification of enantiomeric excess (ee)[8] where a chiral product acts as a chiral catalyst for its own production.[9] Chiral compounds can act as the source of chirality in the addition reaction

of diisopropylzinc (i-Pr $_2$ Zn) to aldehydes to give highly enantioenriched alkanols in combination with asymmetric autocatalysis.[10]–[14]

Here, we report that chiral mesoporous silica acts as a heterogeneous chiral catalyst in the enantioselective addition of iPr $_2$ Zn to pyrimidine-5-carbaldehyde 1 to afford, in combination with asymmetric autocatalysis, 5-pyrimidyl alkanol 2 with a high ee (see Figure 1).

Asymmetric autocatalysis with chiral mesoporous silica — Figure 1. Highly enantioselective synthesis of the 5-pyrimidyl alkanol 2 using chiral mesoporous silica as a heterogeneous solid catalyst in the reaction between i-Pr $_2$ Zn and pyrimidine-5-carbaldehyde 1.

The results of asymmetric autocatalysis in the presence of helical mesoporous silica[7] are summarized in Table 1. In the presence of right-handed enriched helical ( $P$ )-mesoporous silica (Sample A) with approximately 52% ee, ( $S$ )-5-pyrimidyl alkanol with a 97% ee was obtained in a 92% isolated yield from the reaction of pyrimidine-5-carbaldehyde 1 and i-Pr $_2$ Zn (entry 1). When Sample A with a ( $P$ )-helicity was used as the chiral promoter, the same stereochemical outcome was observed, i.e., 5-pyrimidyl alkanol 2 with $S$ chirality was produced in a reproducible manner (entries 2 and 3). In sharp contrast, left-handed enriched ( $M$ )-mesoporous silica Sample B promoted the formation of ( $R$ )-pyrimidyl alkanol 2 with an 80% ee in an 85% yield (entry 4). The stereochemical correlation using Sample B was reproducible and afforded 5-pyrimidyl alkanol 2 possessing $R$ -chirality (entries 5 and 6). For entries 7 and 8, another sample of helical mesoporous silica, Sample C, was subjected to asymmetric autocatalysis. The correlation between the enrichment of the ( $P$ )-helicity of the silica and the ( $S$ )-configuration of alkanol 2 was reproduced well (entries 7 and 8). The formation of ( $R$ )-2 was reproducible when chiral ( $M$ )-enriched mesoporous silica Samples D and E were utilized as the chiral promoters of asymmetric autocatalysis (entries 9–11). It should be noted that near enantiopure products ( $S$ )- and ( $R$ )-2 with >99.5% ee could be obtained by consecutive asymmetric autocatalysis (entries 8 and 10, respectively).[18]

Entry	Lot no.	Chirality	ee $^{c}$ (%)	Yield $^{d}$ (%)	ee $^{e}$ (%)	Config.
1 $^{f}$	A	$P$	52	92	97	$S$
2	A	$P$	52	92	92	$S$
3	A	$P$	52	91	86	$S$
4	B	$M$	19	85	80	$R$
5	B	$M$	19	83	82	$R$
6	B	$M$	19	78	97	$R$
7	C	$P$	39	87	92	$S$
8	C	$P$	39	85	96 $^{g}$ (>99.5)	$S$
9	D	$M$	26	89	86	$R$
10	D	$M$	26	93	93 $^{g}$ (>99.5)	$R$
11	E	$M$	22	91	94	$R$

Table 1. Asymmetric autocatalysis induced by helical mesoporous silica.

Asymmetric autocatalysis is a very powerful reaction for detecting low levels of chirality (crypto chirality) in a substance[15] and, therefore, to ensure that asymmetric induction that occurred was due to the helical structure of the mesoporous silica, thermal analysis (TG–DTA) was performed. As shown in Figure 2, the organic part completely disappeared around 600 °C. Since the chiral mesoporous silica was prepared by calcining the composite precursor at 650 °C for 6 h, only the chiral inorganic framework would remain to act as the chiral source for the enantioselective reaction.[16]

Thermal analysis plots — Figure 2. Thermal analysis (TG–DTA) of (a) $N$ -myristoyl- $\mathrm{L}$ -alanine (5.4 mg, 10 °C min $^{-1}$ , air, 30 mL min $^{-1}$ ) and (b) the surfactant–silica composite (10.1 mg, 10 °C min $^{-1}$ , air, 30 mL min $^{-1}$ ).

The enantioselectivity observed in this reaction can be explained as follows:[17] (1) Asymmetric activation of i-Pr $_2$ Zn by the chiral mesoporous silica induces the formation of a chiral zinc species that enables the enantioselective addition to aldehyde 1. (2) Enantiotopic face selective adsorption of the achiral pyrimidine-5-carbaldehyde 1 to the helical surface of the chiral mesoporous silica enables the addition of i-Pr $_2$ Zn onto the preferred face. (3) Enantioselective adsorption of the initially formed zinc alkoxide of pyrimidyl alkanol 2 induces an enantiomeric imbalance in the reaction solution. Then, the induced enantiomeric imbalance is amplified to provide the overwhelming enantioenrichment of product 2 by subsequent asymmetric autocatalysis.[18]

In conclusion, a highly enantioselective addition of diisopropylzinc to pyrimidine-5-carbaldehyde 1 was achieved to afford a highly

⁸ The typical experimental procedure used is as follows: to a mixture of right-handed enriched ( $P$ )-mesoporous silica (30 mg) with ca. 52% ee and pyrimidine-5-carbaldehyde 1 (9.4 mg, 0.05 mmol) was added a solution of i-Pr $_2$ Zn (0.15 mmol, 0.15 mL of a 1 M toluene solution) at 0 °C, and the mixture was then stirred for 4 h. After the addition of toluene (4.75 mL), i-Pr $_2$ Zn (0.4 mmol, 0.4 mL of a 1 M toluene solution) was added over a period of 30 min at 0 °C. After stirring the mixture for 15 min, a solution of 1 (37.6 mg, 0.2 mmol) in toluene (1.5 mL) was added over a period of 1.5 h. After the mixture was left stirring overnight, toluene (14.4 mL) and a solution of i-Pr $_2$ Zn (1.6 mmol, 1.6 mL of 1 M toluene solution) were added successively, and the resulting mixture was stirred for a further 20 min. A solution of 1 (150.6 mg, 0.8 mmol) in toluene (4.0 mL) was then added over a period of 1 h at 0 °C. After stirring for a further 2 h, the reaction was quenched using 1 M hydrochloric acid (5 mL) and neutralized with a saturated sodium hydrogen carbonate solution (15 mL). The mixture was then filtered using Celite, and the filtrate was extracted three times using ethyl acetate. The combined organic layers were dried over anhydrous sodium sulfate and evaporated in vacuo. Purification of the residue using silica gel column chromatography (hexane/ethyl acetate = 3/1, v/v) gave the ( $S$ )-5-pyrimidyl alkanol 2 (225 mg, 0.968 mmol) with a 97% ee in a yield of 92%. The ee was determined using HPLC, employing a chiral stationary phase (Daicel Chiralcel OD–H, 4.6 × 250 mm, eluent: 2-propanol/hexane = 5/95 (v/v), flow rate: 1.0 mL min $^{-1}$ , 254 nm UV detector, retention time: 10.1 min for ( $S$ )-2, 15.1 min for ( $R$ )-2). After carrying out a typical experimental procedure, additional rounds of consecutive asymmetric autocatalysis were performed.[18] @page 3/4 starts_mid=1 ends_mid=1

enantioenriched organic compound by utilizing chiral mesoporous silica as a source of chirality in conjunction with asymmetric autocatalysis. We have clearly demonstrated that helical mesoporous silica has the capability, due to its large reactive surface, to be responsible for the enantioselective addition of i-Pr $_2$ Zn to pyrimidine-5-carbaldehyde 1. We believe that these results show the potential for using the large reactive surface of chiral mesoporous silica for asymmetric reactions as a chiral inorganic catalyst.

This work was supported by a Grant-in-Aid for Scientific Research from Japan Society for the Promotion of Science (JSPS) and by MEXT-Supported Program for the Strategic Research Foundation at Private Universities, 2012–2016.

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Helical mesoporous silica as an inorganic heterogeneous chiral trigger for asymmetric autocatalysis with amplification of enantiomeric excess

Abstract

Helical mesoporous silica as an inorganic heterogeneous chiral trigger for asymmetric autocatalysis with amplification of enantiomeric excess†

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